About: Pathogenic Role for Virus-Specific CD4 T Cells in Mice with Coronavirus-Induced Acute Encephalitis

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pathogenic Role for Virus-Specific CD4 T Cells in Mice with Coronavirus-Induced Acute Encephalitis
Creator	Perlman, Stanley Pewe, Lecia Anghelina, Daniela
Source	Elsevier; Medline; PMC
abstract	Acute viral encephalitis is believed to result from direct virus destruction of infected cells and from virus-induced host immune response, but the relative contribution of each remains largely unknown. For example, C57BL/6 (B6) mice infected with mouse hepatitis virus (JHM strain, JHMV) develop severe encephalitis, with death occurring within 7 days. Here, we show that the host response to a single JHMV-specific immunodominant CD4 T-cell epitope is critical for severe disease. We engineered a recombinant JHMV with mutations in the immunodominant CD4 T-cell epitope (rJ.M(Y135Q)). Infection of naïve B6 mice with this virus resulted in mild disease with no mortality. However, introduction of a CD4 T-cell epitope from Listeria monocytogenes into rJ.M(Y135Q) generated a highly virulent virus. The decrease in disease severity was not due to a switch from Th1 to Th2 predominance in rJ.M(Y135Q)-infected mice, an effect on CD8 T-cell function, or differential expression of tumor necrosis factor-α by JHMV-specific CD4 T cells. These results show that the response to a single virus-specific CD4 T-cell epitope may contribute to a pathogenic host response in the setting of acute viral disease and that abrogation of this response ameliorates clinical disease without diminishing virus clearance.
has issue date	2006-07-01(xsd:dateTime)
bibo:doi	10.2353/ajpath.2006.051308
bibo:pmid	16816374
has license	bronze-oa
sha1sum (hex)	7bc58a6f36cf62a7d4e064bb18edab126936718d
schema:url	https://doi.org/10.2353/ajpath.2006.051308
resource representing a document's title	Pathogenic Role for Virus-Specific CD4 T Cells in Mice with Coronavirus-Induced Acute Encephalitis
has PubMed Central identifier	PMC1698761
has PubMed identifier	16816374
schema:publication	The American Journal of Pathology
resource representing a document's body	covid:7bc58a6f36cf62a7d4e064bb18edab126936718d#body_text
is schema:about of	named entity 'recombinant' named entity 'severe' named entity 'Mice' covid:arg/7bc58a6f36cf62a7d4e064bb18edab126936718d named entity 'clearance' named entity 'T-cell' named entity 'disease' named entity 'response' named entity 'CD4' named entity 'Listeria monocytogenes' named entity 'Infection' named entity 'Th1' named entity 'immune response' named entity 'CD8 T-cell' named entity 'virus' named entity 'viral disease' named entity 'C57BL/6' named entity 'host response' named entity 'recombinant' named entity 'CD4 T-cell' named entity 'CD4' named entity 'Mice' named entity 'Acute Encephalitis' named entity 'staining' named entity 'CD4 T cells' named entity 'cytokine' named entity 'Tetramer' named entity 'mice' named entity 'murine' named entity 'epitope' named entity 'epitope' named entity 'neutralizing antibody' named entity 'brain and spinal cord' named entity 'lateral hypothalamus' named entity 'CD4 T cell' named entity 'MHC class II' named entity 'HSV-1' named entity 'virus' named entity 'mice' named entity 'acute encephalitis' named entity 'mice' named entity 'phosphate-buffered saline' named entity 'epitopes' named entity 'IFN' named entity 'cytolytic' named entity 'West Grove' named entity 'RSV' named entity 'recombination' named entity 'mice' named entity 'lymphocytes' named entity 'mice' named entity 'Recombinant' named entity 'epitopes' named entity 'reticular formation' named entity 'mutation' named entity 'CD4 T-cell' named entity 'primers' named entity 'mice' named entity 'virus' named entity 'clone' named entity 'CD4 T-cell' named entity 'intracellular' named entity 'intranasally' named entity 'ionomycin' named entity 'cytokine' named entity 'CD4 T-cell' named entity '28 days' named entity 'lymphocytes' named entity 'RSV' named entity 'Gln' named entity 'HIV-1' named entity 'M133' named entity 'virus' named entity 'seizures' named entity 'CD4 T cells' named entity 'respiratory disease' named entity 'cytolytic' named entity 'chronic diseases' named entity 'recombinants'

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