About: The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry

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About: The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry
Creator	Ciesek, Sandra Becker, Stephan Mittler, Eva Dahlmann, Franziska Pö Hlmann, Stefan Vondran, Florian Manns, Michael Von Hahn, Thomas Atenchong, Nkacheh David, Sascha Gehring, Gerrit Rohrmann, Katrin
Source	Medline; PMC
abstract	OBJECTIVES: Filoviruses such as Ebola virus and Marburg virus cause a severe haemorrhagic fever syndrome in humans for which there is no specific treatment. Since filoviruses use a complex route of cell entry that depends on numerous cellular factors, we hypothesized that there may be drugs already approved for human use for other indications that interfere with signal transduction or other cellular processes required for their entry and hence have anti-filoviral properties. METHODS: We used authentic filoviruses and lentiviral particles pseudotyped with filoviral glycoproteins to identify and characterize such compounds. RESULTS: We discovered that amiodarone, a multi-ion channel inhibitor and adrenoceptor antagonist, is a potent inhibitor of filovirus cell entry at concentrations that are routinely reached in human serum during anti-arrhythmic therapy. A similar effect was observed with the amiodarone-related agent dronedarone and the L-type calcium channel blocker verapamil. Inhibition by amiodarone was concentration dependent and similarly affected pseudoviruses as well as authentic filoviruses. Inhibition of filovirus entry was observed with most but not all cell types tested and was accentuated by the pre-treatment of cells, indicating a host cell-directed mechanism of action. The New World arenavirus Guanarito was also inhibited by amiodarone while the Old World arenavirus Lassa and members of the Rhabdoviridae (vesicular stomatitis virus) and Bunyaviridae (Hantaan) families were largely resistant. CONCLUSIONS: The ion channel blockers amiodarone, dronedarone and verapamil inhibit filoviral cell entry.
has issue date	2014-08-01(xsd:dateTime)
bibo:doi	10.1093/jac/dku091
bibo:pmid	24710028
has license	no-cc
sha1sum (hex)	7b63de107cfe8a08c45fe8b06dbcf365b7ee0fd1
schema:url	https://doi.org/10.1093/jac/dku091
resource representing a document's title	The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry
has PubMed Central identifier	PMC7110251
has PubMed identifier	24710028
schema:publication	J Antimicrob Chemother
resource representing a document's body	covid:7b63de107cfe8a08c45fe8b06dbcf365b7ee0fd1#body_text
is schema:about of	named entity 'FILOVIRUS' named entity 'factors' named entity 'cell' named entity 'AMIODARONE' named entity 'ROUTE' named entity 'CAUSE' named entity 'MARBURG VIRUS ' named entity 'INDICATIONS' named entity 'COMPLEX' named entity 'REQUIRED' named entity 'CELLULAR' named entity 'USE' named entity 'CELLULAR PROCESSES' named entity 'THEIR' named entity 'HUMANS' named entity 'SIGNAL TRANSDUCTION' named entity 'APPROVED' named entity 'SEVERE' named entity 'HAEMORRHAGIC FEVER' named entity 'PROPERTIES' named entity 'NUMEROUS' named entity 'ENTRY' named entity 'DRUGS' named entity 'TREATMENT' named entity 'MAY BE' named entity 'SYNDROME' named entity 'EBOLA VIRUS' named entity 'HAVE' named entity 'APPROVED' named entity 'DRUGS' named entity 'CELL' named entity 'INTERFERE' named entity 'HUMAN USE' named entity 'SPECIFIC' named entity 'CELL' named entity 'OBJECTIVES' named entity 'FILOVIRUSES' named entity 'DRONEDARONE' named entity 'VERAPAMIL' named entity 'ENTRY' covid:arg/7b63de107cfe8a08c45fe8b06dbcf365b7ee0fd1 named entity 'cellular' named entity 'haemorrhagic fever' named entity 'hypothesized' named entity 'Filoviruses' named entity 'amiodarone' named entity 'approved drugs' named entity 'filovirus' named entity 'bevacizumab' named entity 'lentiviral' named entity 'filoviruses' named entity 'Rhabdoviridae' named entity 'amiodarone' named entity 'host cell' named entity 'epithelial cells' named entity 'amiodarone' named entity 'non-specific' named entity 'vaccine' named entity 'RPMI' named entity 'metoprolol' named entity 'dronedarone' named entity 'antiviral treatment' named entity 'mechanism of action' named entity 'acid sphingomyelinase' named entity 'late endosome' named entity 'genome' named entity 'viral replication' named entity 'theophylline' named entity 'antiviral' named entity 'HIV'

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