About: Comprehensive Analysis and Comparison on the Codon Usage Pattern of Whole Mycobacterium tuberculosis Coding Genome from Different Area

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About: Comprehensive Analysis and Comparison on the Codon Usage Pattern of Whole Mycobacterium tuberculosis Coding Genome from Different Area Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Comprehensive Analysis and Comparison on the Codon Usage Pattern of Whole Mycobacterium tuberculosis Coding Genome from Different Area
Creator	Gun, Li Haixian, Pan Liang, Zhang Yumiao, Ren
source	PMC
abstract	Phenomenon of unequal use of synonymous codons in Mycobacterium tuberculosis is common. Codon usage bias not only plays an important regulatory role at the level of gene expression, but also helps in improving the accuracy and efficiency of translation. Meanwhile, codon usage pattern of Mycobacterium tuberculosis genome is important for interpreting evolutionary characteristics in species. In order to investigate the codon usage pattern of the Mycobacterium tuberculosis genome, 12 Mycobacterium tuberculosis genomes from different area are downloaded from the GeneBank. The correlations between G(3), GC(12), whole GC content, codon adaptation index, codon bias index, and so on of Mycobacterium tuberculosis genomes are calculated. The ENC-plot, relationship between A(3)/(A(3) + T(3)) and G(3)/(G(3) + C(3)), GC(12) versus GC(3) plot, and the RSCU of overall/separated genomes all show that the codon usage bias exists in all 12 Mycobacterium tuberculosis genomes. Lastly, relationship between CBI and the equalization of ENC shows a strong negative correlation between them. The relationship between protein length and GC content (GC(3) and GC(12)) shows that more obvious differences in the GC content may be in shorter protein. These results show that codon usage bias existing in the Mycobacterium tuberculosis genomes could be used for further study on their evolutionary phenomenon.
has issue date	2018-05-08(xsd:dateTime)
bibo:doi	10.1155/2018/3574976
bibo:pmid	29854746
has license	cc-by
sha1sum (hex)	798026310eaadd09df393473a730d6935f91b4d4
schema:url	https://doi.org/10.1155/2018/3574976
resource representing a document's title	Comprehensive Analysis and Comparison on the Codon Usage Pattern of Whole Mycobacterium tuberculosis Coding Genome from Different Area
has PubMed Central identifier	PMC5964552
has PubMed identifier	29854746
schema:publication	Biomed Res Int
resource representing a document's body	covid:798026310eaadd09df393473a730d6935f91b4d4#body_text
is schema:about of	named entity 'GC content' named entity 'codon' named entity 'phenomenon' named entity 'Coding' named entity 'DIFFERENT' named entity 'PATTERN' named entity 'CORRELATION' named entity 'GC CONTENT' named entity 'IMPROVING' named entity 'COMMON' named entity 'GENOMES' named entity 'CBI' named entity 'MYCOBACTERIUM TUBERCULOSIS' named entity 'AREA' named entity 'THEIR' named entity 'CODON USAGE' named entity 'UNEQUAL' named entity 'REGULATORY ROLE' named entity 'GENOME' named entity 'LENGTH' named entity 'DIFFERENT' named entity 'OVERALL' named entity 'RELATIONSHIP' named entity 'CHARACTERISTICS' named entity 'THESE' named entity 'USE OF' named entity 'T 3' named entity 'TRANSLATION' named entity 'MYCOBACTERIUM TUBERCULOSIS' named entity 'CODON BIAS' named entity 'TO INVESTIGATE' named entity 'PLAYS' named entity 'RESULTS' named entity 'COMPREHENSIVE ANALYSIS' named entity 'COMPARISON' named entity 'CODON USAGE' named entity 'EQUALIZATION' named entity 'CODON ADAPTATION INDEX' named entity 'GENE EXPRESSION' named entity 'CORRELATIONS' named entity 'INTERPRETING' named entity 'BUT' named entity 'LEVEL' named entity 'EFFICIENCY' named entity 'IMPORTANT' named entity 'ORDER' named entity 'PROTEIN' named entity '28A' named entity 'SYNONYMOUS' named entity 'PHENOMENON' named entity '28G' named entity 'ENC' named entity 'AREA' named entity 'CALCULATED' named entity 'MAY BE' named entity 'SPECIES' named entity 'PROTEIN ' named entity 'PATTERN' named entity 'STRONG' named entity 'OBVIOUS' named entity 'PLOT' named entity 'GENOME' named entity 'INDEX' named entity 'USED' named entity 'NEGATIVE' named entity 'CODONS' named entity 'CODING' named entity 'STUDY' named entity 'ACCURACY' named entity 'CODON USAGE BIAS' named entity 'HELPS' covid:arg/798026310eaadd09df393473a730d6935f91b4d4 named entity 'plays' named entity 'codon' named entity 'The' named entity 'Mycobacterium tuberculosis' named entity 'These' named entity 'genomes'

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