About: Dieckol, a Component of Ecklonia cava, Suppresses the Production of MDC/CCL22 via Down-Regulating STAT1 Pathway in Interferon-γ Stimulated HaCaT Human Keratinocytes

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About: Dieckol, a Component of Ecklonia cava, Suppresses the Production of MDC/CCL22 via Down-Regulating STAT1 Pathway in Interferon-γ Stimulated HaCaT Human Keratinocytes Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Dieckol, a Component of Ecklonia cava, Suppresses the Production of MDC/CCL22 via Down-Regulating STAT1 Pathway in Interferon-γ Stimulated HaCaT Human Keratinocytes
Creator	Han, Sang-Chul Hyun, Jin-Won Kang, Gyeoung-Jin Kang, Hee-Kyoung Kang, Na-Jin Ko, Mi-Hee Koh, Young-Sang Koo, Dong-Hwan Lee, Bang-Won Lee, Nam-Ho Yoo, Eun-Sook
Source	PMC
abstract	Macrophage-derived chemokine, C-C motif chemokine 22 (MDC/CCL22), is one of the inflammatory chemokines that controls the movement of monocytes, monocyte-derived dendritic cells, and natural killer cells. Serum and skin MDC/CCL22 levels are elevated in atopic dermatitis, which suggests that the chemokines produced from keratinocytes are responsible for attracting inflammatory lymphocytes to the skin. A major signaling pathway in the interferon-γ (IFN-γ)-stimulated inflammation response involves the signal transducers and activators of transcription 1 (STAT1). In the present study, we investigated the anti-inflammatory effect of dieckol and its possible action mechanisms in the category of skin inflammation including atopic dermatitis. Dieckol inhibited MDC/CCL22 production induced by IFN-γ (10 ng/mL) in a dose dependent manner. Dieckol (5 and 10 μM) suppressed the phosphorylation and the nuclear translocation of STAT1. These results suggest that dieckol exhibits anti-inflammatory effect via the down-regulation of STAT1 activation.
has issue date	2015-05-01(xsd:dateTime)
bibo:doi	10.4062/biomolther.2014.141
bibo:pmid	25995822
has license	cc-by-nc
sha1sum (hex)	78dc2abf39a665aec9b4a48738a2b4b838bfe72e
schema:url	https://doi.org/10.4062/biomolther.2014.141
resource representing a document's title	Dieckol, a Component of Ecklonia cava, Suppresses the Production of MDC/CCL22 via Down-Regulating STAT1 Pathway in Interferon-γ Stimulated HaCaT Human Keratinocytes
has PubMed Central identifier	PMC4428716
has PubMed identifier	25995822
schema:publication	Biomol Ther (Seoul)
resource representing a document's body	covid:78dc2abf39a665aec9b4a48738a2b4b838bfe72e#body_text
is schema:about of	named entity 'INTERFERON' named entity 'PRODUCTION' named entity 'HACAT' named entity 'DIECKOL' named entity 'STIMULATED' named entity 'COMMERCIAL LICENSE' named entity 'REPRODUCTION' named entity 'ACCESS' named entity 'DISTRIBUTED' named entity 'ORIGINAL' named entity 'PROVIDED' named entity 'SUPPRESSES' named entity 'PATHWAY' named entity 'STAT1' named entity 'REGULATING' named entity 'MDC' named entity 'TERMS' named entity 'COMPONENT' named entity 'DISTRIBUTION' named entity 'ATTRIBUTION' named entity 'ORG' named entity 'ARTICLE' named entity 'OPEN' named entity 'HUMAN' named entity 'ECKLONIA CAVA' named entity 'KERATINOCYTES' named entity 'MEDIUM' named entity 'WORK' named entity 'PERMITS' named entity 'NON-' named entity 'UNRESTRICTED' named entity 'CREATIVE COMMONS' covid:arg/78dc2abf39a665aec9b4a48738a2b4b838bfe72e named entity 'Open Access' named entity 'CCL22' named entity 'protein' named entity 'oil immersion' named entity 'assay' named entity 'transcription of target genes' named entity 'BioLegend' named entity 'HaCaT' named entity 'functional food' named entity 'Jeju island' named entity 'STAT1' named entity 'transcriptional activity' named entity 'IFN-γ receptor' named entity 'immunomodulatory' named entity 'HaCaT' named entity 'phosphorylation' named entity 'Sunnyvale' named entity 'cosmetics' named entity 'EGCG' named entity 'eckol' named entity 'HaCaT' named entity 'IFN-γ' named entity 'statistical significance' named entity 'dieckol' named entity 'ethylene glycol' named entity 'cell type' named entity 'phenylmethylsulfonyl fluoride' named entity 'SP600125' named entity 'Japan' named entity 'Chemokine' named entity 'ImageJ' named entity 'ERK' named entity 'EGTA' named entity 'NK cells' named entity 'IFN-γ' named entity 'recombinant' named entity 'eckol' named entity 'antibody'

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