About: Structure of the SARS-CoV NSP12 polymerase bound to NSP7 and NSP8 co-factors

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About: Structure of the SARS-CoV NSP12 polymerase bound to NSP7 and NSP8 co-factors Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Structure of the SARS-CoV NSP12 polymerase bound to NSP7 and NSP8 co-factors
Creator	Kirchdoerfer, Robert Ward, Andrew
Source	BioRxiv; MedRxiv
abstract	Recent history is punctuated by the emergence of highly pathogenic coronaviruses such as SARS- and MERS-CoV into human circulation. Upon infecting host cells, coronaviruses assemble a multi-subunit RNA-synthesis complex of viral non-structural proteins (NSP) responsible for the replication and transcription of the viral genome. Here, we present the 3.1 Å resolution structure of the SARS-CoV NSP12 polymerase bound to its essential co-factors, NSP7 and NSP8, using single particle cryo-electron microscopy. NSP12 possesses an architecture common to all viral polymerases as well as a large N-terminal extension containing a kinase-like fold and is unexpectedly bound by two NSP8 co-factors. This structure illuminates the assembly of the coronavirus core RNA-synthesis machinery, provides key insights into NSP12 polymerase catalysis and fidelity and acts as a template for the design of novel antiviral therapeutics.
has issue date	2019-02-15(xsd:dateTime)
bibo:doi	10.1101/551986
has license	biorxiv
sha1sum (hex)	77a04c5091c0457ad305691d4d4f24354d6bae79
schema:url	https://doi.org/10.1101/551986
resource representing a document's title	Structure of the SARS-CoV NSP12 polymerase bound to NSP7 and NSP8 co-factors
schema:publication	bioRxiv
resource representing a document's body	covid:77a04c5091c0457ad305691d4d4f24354d6bae79#body_text
is schema:about of	named entity 'transcription' named entity 'MERS-CoV' named entity 'BOUND' named entity 'KEY' named entity 'MULTI' covid:arg/77a04c5091c0457ad305691d4d4f24354d6bae79 named entity 'COMMON' named entity 'HERE' named entity 'INFECTING' named entity 'SARS-COV' named entity 'POLYMERASE' named entity 'N-TERMINAL ' named entity 'RECENT' named entity 'CIRCULATION' named entity 'HUMAN' named entity 'BOUND' named entity 'SINGLE PARTICLE CRYO-ELECTRON MICROSCOPY' named entity 'ASSEMBLE' named entity 'RESOLUTION' named entity 'CORONAVIRUSES' named entity 'PROVIDES' named entity 'TEMPLATE' named entity 'POSSESSES' named entity 'TRANSCRIPTION' named entity 'SYNTHESIS' named entity 'PATHOGENIC' named entity 'CORONAVIRUS' named entity 'DESIGN' named entity 'POLYMERASE' named entity 'ANTIVIRAL' named entity 'STRUCTURE' named entity 'INSIGHTS' named entity 'CATALYSIS' named entity 'HOST CELLS' named entity 'CORE' named entity 'EXTENSION' named entity 'SUBUNIT' named entity 'ARCHITECTURE' named entity 'FIDELITY' named entity 'PRESENT' named entity 'VIRAL NON-STRUCTURAL PROTEINS' named entity 'SARS' named entity 'ITS' named entity 'KINASE' named entity 'REPLICATION' named entity 'MACHINERY' named entity 'RNA' named entity 'ASSEMBLY' named entity 'LIKE' named entity 'SARS-COV' named entity 'THERAPEUTICS' named entity 'RESPONSIBLE' named entity 'LARGE' named entity 'VIRAL' named entity 'NOVEL' named entity 'USING' named entity 'HISTORY' named entity 'EMERGENCE' named entity 'ESSENTIAL' named entity 'CONTAINING' named entity 'FOLD' named entity '3.1' named entity 'MERS-COV' named entity 'VIRAL GENOME' named entity 'ACTS' named entity 'COMPLEX' named entity 'HIGHLY' named entity 'POLYMERASES' named entity 'STRUCTURE' named entity 'single' named entity 'therapeutics' named entity 'particle' named entity 'assembly' named entity 'large' named entity 'polymerase' named entity 'viral genome' named entity 'SARS' named entity 'co-factors' named entity 'antiviral' named entity 'SARS-CoV' named entity 'coronavirus' named entity 'polymerase' named entity 'MERS-CoV'

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