About: Impaired production of immune mediators in dengue virus type 2-infected mononuclear cells of adults with end stage renal disease

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About: Impaired production of immune mediators in dengue virus type 2-infected mononuclear cells of adults with end stage renal disease Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Impaired production of immune mediators in dengue virus type 2-infected mononuclear cells of adults with end stage renal disease
Creator	Lee, Ing-Kit Chen, Yi-Chun Huang, Wen-Chi Lee, Chien-Te Li, Lung-Chih Ng, Hwee-Yeong Tsai, Ching-Yen Yang, Zih-Syuan
Source	PMC
abstract	Chronic kidney disease is an epidemiologically identified risk factor for development of severe dengue in dengue-affected patients. However, available data on the immune pathogenesis in end stage renal disease (ESRD) patients affected by dengue is insufficient. We performed an in vitro study to evaluate the sequential immunological reactions and viral load in dengue virus type 2-infected mononuclear cells of patients with ESRD (n = 34) and in healthy controls (n = 30). The concentrations of interleukins (IL)-1 receptor antagonist (Ra), IL-2, IL-6, IL-8, IL-10, IL-12p40, granulocyte-macrophage colony-stimulating factor (GM-CSF), monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1b (MIP-1b), vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF)-α and viral load cycle threshold (Ct) were measured in the dengue virus type 2-infected mononuclear cells at 6 h, 24 h, 48 h, and 72 h post-infection. We found in the ESRD group significantly higher GM-CSF and IL-2 levels at 6 h post-infection. However, IL-8, IL-10, IL-12p40, TNF-α, MCP-1, and MIP-1b levels were found significantly lower than in the control group. At 24 h, 48 h, and 72 h post-infection, significantly lower levels of IL-1Ra, IL-6, IL-8, IL-10, IL-12p40, TNF-α, MCP-1, and MIP-1b were detected in ESRD group. Concentration of VEGF at 24 h and 48 h, and of GM-CSF at 48 h and 72 h were also found to be lower in ESRD group than in control group. Compared with controls, the viral load Ct values were significantly lower in ESRD group at 6 h and 24 h post-infection No significant difference in viral load Ct values between two groups was found at 48 h and 72 h post-infection. Our study discloses that the expression of immune mediators of dengue-infected mononuclear cells is impaired in ESRD patients.
has issue date	2019-12-24(xsd:dateTime)
bibo:doi	10.1038/s41598-019-56381-3
bibo:pmid	31875015
has license	cc-by
sha1sum (hex)	75356982697a153bdd8610fe024820f7308bb6a2
schema:url	https://doi.org/10.1038/s41598-019-56381-3
resource representing a document's title	Impaired production of immune mediators in dengue virus type 2-infected mononuclear cells of adults with end stage renal disease
has PubMed Central identifier	PMC6930266
has PubMed identifier	31875015
schema:publication	Sci Rep
resource representing a document's body	covid:75356982697a153bdd8610fe024820f7308bb6a2#body_text
is schema:about of	named entity 'END STAGE RENAL DISEASE' named entity 'MONONUCLEAR CELLS' named entity 'PATIENTS' named entity 'AFFECTED PATIENTS' named entity 'IMMUNOLOGICAL' named entity 'PERFORMED' named entity 'SEQUENTIAL' named entity 'CONCENTRATIONS' named entity 'ESRD' named entity 'IDENTIFIED' named entity '30%' named entity 'CSF' named entity 'DEVELOPMENT' named entity 'DENGUE' named entity 'AFFECTED' named entity 'DIFFERENCE' named entity 'INFECTED' named entity 'vascular endothelial growth factor (VEGF)' named entity 'risk factor' named entity 'dengue virus' named entity 'However' named entity 'cells' named entity 'However' named entity 'cells' named entity 'group' named entity 'Concentration' named entity 'adults' named entity 'groups' named entity 'IL-12p40' named entity 'IL-12p40' named entity 'ESRD' named entity 'renal' named entity 'IL-2' named entity 'VEGF' named entity 'MIP-1B' named entity 'PRODUCTION' named entity 'INFECTION' named entity 'MCP-1' named entity 'IL-10' named entity 'TUMOR NECROSIS FACTOR ' named entity 'INFECTED' named entity 'INTERLEUKINS' named entity 'IL-6' named entity 'EVALUATE' named entity 'IN VITRO STUDY' named entity 'CYCLE THRESHOLD' named entity 'MONOCYTE CHEMOTACTIC PROTEIN-1' named entity 'DENGUE VIRUS TYPE 2' named entity 'DATA' named entity 'RISK FACTOR' named entity 'IL-2' named entity 'REACTIONS' named entity 'IMPAIRED' named entity 'FOUND' named entity 'GROUPS' named entity 'IL-8' named entity 'IL-12P40' named entity 'DENGUE VIRUS TYPE 2' named entity 'STUDY' named entity 'COMPARED' named entity 'OUR' named entity 'END STAGE RENAL DISEASE' named entity 'DENGUE' named entity 'IMMUNE MEDIATORS' named entity 'HIGHER' named entity 'IL-6' named entity '2 LEVELS' named entity 'POST' named entity 'IL-1RA' named entity 'VALUES' named entity 'GROUP' named entity 'CONCENTRATION OF' named entity 'CONTROL GROUP' named entity 'MONONUCLEAR CELLS'

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