About: An Animal Model of MERS Produced by Infection of Rhesus Macaques With MERS Coronavirus

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About: An Animal Model of MERS Produced by Infection of Rhesus Macaques With MERS Coronavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	An Animal Model of MERS Produced by Infection of Rhesus Macaques With MERS Coronavirus
Creator	Yuen, Kwok-Yung Chen, Ting Yuan, Jing Qin, Chuan Xu, Yanfeng Xu, Lili Lv, Qi Yao, Yanfeng Chen, Honglin Wei, Qiang Zhu, Hua Bao, Linlin Deng, Wei Yu, Pin Li, Fengdi Gu, Songzhi
Source	Medline; PMC
abstract	In 2012, a novel coronavirus (CoV) associated with severe respiratory disease, Middle East respiratory syndrome (MERS-CoV; previously known as human coronavirus–Erasmus Medical Center or hCoV-EMC), emerged in the Arabian Peninsula. To date, 114 human cases of MERS-CoV have been reported, with 54 fatalities. Animal models for MERS-CoV infection of humans are needed to elucidate MERS pathogenesis and to develop vaccines and antivirals. In this study, we developed rhesus macaques as a model for MERS-CoV using intratracheal inoculation. The infected monkeys showed clinical signs of disease, virus replication, histological lesions, and neutralizing antibody production, indicating that this monkey model is suitable for studies of MERS-CoV infection.
has issue date	2014-01-15(xsd:dateTime)
bibo:doi	10.1093/infdis/jit590
bibo:pmid	24218506
has license	no-cc
sha1sum (hex)	75232f1c2ce74f3d48e406ee145b0809fc3284f0
schema:url	https://doi.org/10.1093/infdis/jit590
resource representing a document's title	An Animal Model of MERS Produced by Infection of Rhesus Macaques With MERS Coronavirus
has PubMed Central identifier	PMC7107340
has PubMed identifier	24218506
schema:publication	J Infect Dis
resource representing a document's body	covid:75232f1c2ce74f3d48e406ee145b0809fc3284f0#body_text
is schema:about of	named entity 'monkeys' named entity 'Middle East respiratory syndrome' named entity 'respiratory disease' named entity 'Medical Center' named entity 'ASSOCIATED WITH' named entity 'HISTOLOGICAL' named entity '114' named entity 'MERS' named entity 'SUITABLE' named entity 'STUDY' named entity 'ARABIAN PENINSULA' named entity 'REPORTED' named entity 'EMC' named entity 'FATALITIES' named entity 'ANIMAL MODELS ' named entity 'RESPIRATORY DISEASE' named entity 'PATHOGENESIS' named entity 'HUMANS' named entity 'INDICATING' named entity 'MODEL OF' named entity 'ANIMAL MODEL' named entity 'MERS' named entity 'INFECTION' named entity 'INFECTION' named entity 'LESIONS' named entity 'VACCINES' named entity 'VIRUS REPLICATION' named entity 'ANTIVIRALS' named entity 'NOVEL CORONAVIRUS' named entity 'USING' named entity 'INOCULATION' named entity 'MEDICAL CENTER' named entity 'HUMAN' named entity 'RHESUS MACAQUES' named entity 'NEEDED' named entity 'INFECTED' named entity 'KNOWN' named entity 'RHESUS MACAQUES' named entity 'MIDDLE EAST RESPIRATORY SYNDROME ' named entity 'DISEASE' named entity 'MODEL' named entity 'MONKEYS' named entity 'SEVERE' named entity 'MERS-COV' named entity 'DATE' named entity 'NEUTRALIZING ANTIBODY' named entity 'STUDIES' named entity 'HAVE' named entity 'CASES' named entity 'INTRATRACHEAL' named entity 'HUMAN CORONAVIRUS' named entity 'MONKEY' named entity 'PREVIOUSLY' named entity 'ANTIBODY PRODUCTION' covid:arg/75232f1c2ce74f3d48e406ee145b0809fc3284f0 named entity 'severe' named entity 'studies' named entity 'MERS-CoV' named entity 'MERS' named entity 'rhesus macaques' named entity 'production' named entity 'respiratory disease' named entity 'virus replication' named entity 'Middle East respiratory syndrome' named entity 'rhesus macaques' named entity 'MERS-CoV'

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