About: Replication and Shedding of MERS-CoV in Upper Respiratory Tract of Inoculated Dromedary Camels

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About: Replication and Shedding of MERS-CoV in Upper Respiratory Tract of Inoculated Dromedary Camels Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Replication and Shedding of MERS-CoV in Upper Respiratory Tract of Inoculated Dromedary Camels
Creator	Munster, Vincent Bushmaker, Trenton Scott, Dana Bowen, Richard Adney, Danielle De Wit, Emmie Van Doremalen, Neeltje Brown, Vienna Bushmaker, D De Wit, V Doremalen, T Munster, Scott, E
Source	Medline; PMC
abstract	In 2012, a novel coronavirus associated with severe respiratory disease in humans emerged in the Middle East. Epidemiologic investigations identified dromedary camels as the likely source of zoonotic transmission of Middle East respiratory syndrome coronavirus (MERS-CoV). Here we provide experimental support for camels as a reservoir for MERS-CoV. We inoculated 3 adult camels with a human isolate of MERS-CoV and a transient, primarily upper respiratory tract infection developed in each of the 3 animals. Clinical signs of the MERS-CoV infection were benign, but each of the camels shed large quantities of virus from the upper respiratory tract. We detected infectious virus in nasal secretions through 7 days postinoculation, and viral RNA up to 35 days postinoculation. The pattern of shedding and propensity for the upper respiratory tract infection in dromedary camels may help explain the lack of systemic illness among naturally infected camels and the means of efficient camel-to-camel and camel-to-human transmission.
has issue date	2014-12-01(xsd:dateTime)
bibo:doi	10.3201/eid2012.141280
bibo:pmid	25418529
has license	no-cc
sha1sum (hex)	74ae352ed6606527cca17ab3b773687251f38590
schema:url	https://doi.org/10.3201/eid2012.141280
resource representing a document's title	Replication and Shedding of MERS-CoV in Upper Respiratory Tract of Inoculated Dromedary Camels
has PubMed Central identifier	PMC4257817
has PubMed identifier	25418529
schema:publication	Emerg Infect Dis
resource representing a document's body	covid:74ae352ed6606527cca17ab3b773687251f38590#body_text
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