About: Hepatitis E in southern Vietnam: Seroepidemiology in humans and molecular epidemiology in pigs

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Hepatitis E in southern Vietnam: Seroepidemiology in humans and molecular epidemiology in pigs
Creator	Baker, S City, Minh Berto, A Caddy, S Goodfellow, I Boni, M Carrique-Mas, J Hiraide, R Id, T Pham, H Thao, Thwaites, G Tue, N Vy, N
Source	PMC
abstract	Viral pathogens account for a significant proportion of the burden of emerging infectious diseases in humans. The Wellcome Trust-Vietnamese Initiative on Zoonotic Infections (WT-VIZIONS) is aiming to understand the circulation of viral zoonotic pathogens in animals that pose a potential risk to human health. Evidence suggests that human exposure and infections with hepatitis E virus (HEV) genotypes (GT) 3 and 4 results from zoonotic transmission. Hypothesising that HEV GT3 and GT4 are circulating in the Vietnamese pig population and can be transmitted to humans, we aimed to estimate the seroprevalence of HEV exposure in a population of farmers and the general population. We additionally performed sequence analysis of HEV in pig populations in the same region to address knowledge gaps regarding HEV circulation and to evaluate if pigs were a potential source of HEV exposure. We found a high prevalence of HEV GT3 viral RNA in pigs (19.1% in faecal samples and 8.2% in rectal swabs) and a high HEV seroprevalence in pig farmers (16.0%) and a hospital-attending population (31.7%) in southern Vietnam. The hospital population was recruited as a general-population proxy even though this particular population subgroup may introduce bias. The detection of HEV RNA in pigs indicates that HEV may be a zoonotic disease risk in this location, although a larger sample size is required to infer an association between HEV positivity in pigs and seroprevalence in humans.
has issue date	2018-02-01(xsd:dateTime)
bibo:doi	10.1111/zph.12364
bibo:pmid	28598034
has license	cc-by
sha1sum (hex)	735dca3ec505ecf1a2e01d913c945a7d18f3efcf
schema:url	https://doi.org/10.1111/zph.12364
resource representing a document's title	Hepatitis E in southern Vietnam: Seroepidemiology in humans and molecular epidemiology in pigs
has PubMed Central identifier	PMC6645987
has PubMed identifier	28598034
schema:publication	Zoonoses Public Health
resource representing a document's body	covid:735dca3ec505ecf1a2e01d913c945a7d18f3efcf#body_text
is schema:about of	named entity 'circulation' named entity 'Wellcome' named entity 'swabs' named entity 'bias' named entity 'Initiative' named entity 'Zoonotic' named entity 'rectal' named entity 'Manuscripts' named entity 'PMC' named entity 'VIETNAM' named entity 'AUTHOR' named entity 'HUMANS' named entity 'INFER' named entity 'RISK' named entity 'SIGNIFICANT' named entity 'ANIMALS' named entity 'EVIDENCE' named entity 'HEV' named entity 'INTRODUCE' named entity 'GENERAL' named entity 'LOCATION' named entity 'REGION' named entity 'ATTENDING' named entity 'HEPATITIS E VIRUS' named entity 'SUBGROUP' named entity 'POSE' named entity 'LARGER' named entity 'RECTAL' named entity 'SEQUENCE ANALYSIS' named entity 'RESULTS' named entity 'VIRAL RNA' named entity 'GAPS' named entity 'GT4' named entity 'TRANSMISSION' named entity 'VIRAL' named entity 'POPULATION' named entity 'HOSPITAL' named entity 'INFECTIONS' named entity 'ZOONOTIC PATHOGENS' named entity 'SEROPREVALENCE' named entity 'ZOONOTIC INFECTIONS' named entity 'GENERAL POPULATION' named entity 'UNDERSTAND' named entity 'CIRCULATION' named entity 'MAY BE A' named entity 'EMERGING INFECTIOUS DISEASES' named entity 'SWABS' named entity 'HEV RNA' named entity 'EUROPE' named entity 'PIGS' named entity 'ASSOCIATION' named entity 'SAMPLES' named entity 'PROPORTION' named entity 'ADDRESS' named entity 'TRANSMITTED' named entity 'DETECTION' named entity 'EXPOSURE' named entity 'BIAS' named entity 'DISEASE RISK' named entity 'FOUND' named entity 'CIRCULATING' named entity 'HIGH' named entity 'HUMANS' named entity 'HIGH PREVALENCE' named entity 'GENOTYPES' named entity 'MOLECULAR EPIDEMIOLOGY' named entity 'GROUP' named entity 'MANUSCRIPTS'

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