About: GI-type T4SS-mediated horizontal transfer of the 89K pathogenicity island in epidemic Streptococcus suis serotype 2

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About: GI-type T4SS-mediated horizontal transfer of the 89K pathogenicity island in epidemic Streptococcus suis serotype 2 Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	GI-type T4SS-mediated horizontal transfer of the 89K pathogenicity island in epidemic Streptococcus suis serotype 2
Creator	Zhao, Yan Cheng, Hao Rao, Xiancai Li, Ming Han, Huiming Yan, Jinghua Zheng, Beiwen Wang, Changjun Liu, Di Gao, George Tang, Jiaqi Hu, Fuquan Shen, Xiaodong
Source	PMC
abstract	Pathogenicity islands (PAIs), a distinct type of genomic island (GI), play important roles in the rapid adaptation and increased virulence of pathogens. 89K is a newly identified PAI in epidemic Streptococcus suis isolates that are related to the two recent large-scale outbreaks of human infection in China. However, its mechanism of evolution and contribution to the epidemic spread of S. suis 2 remain unknown. In this study, the potential for mobilization of 89K was evaluated, and its putative transfer mechanism was investigated. We report that 89K can spontaneously excise to form an extrachromosomal circular product. The precise excision is mediated by an 89K-borne integrase through site-specific recombination, with help from an excisionase. The 89K excision intermediate acts as a substrate for lateral transfer to non-89K S. suis 2 recipients, where it reintegrates site-specifically into the target site. The conjugal transfer of 89K occurred via a GI type IV secretion system (T4SS) encoded in 89K, at a frequency of 10(−6) transconjugants per donor. This is the first demonstration of horizontal transfer of a Gram-positive PAI mediated by a GI-type T4SS. We propose that these genetic events are important in the emergence, pathogenesis and persistence of epidemic S. suis 2 strains.
has issue date	2011-03-01(xsd:dateTime)
bibo:doi	10.1111/j.1365-2958.2011.07553.x
bibo:pmid	21244532
has license	cc-by
sha1sum (hex)	7212e4cdbb493aa171b9d07c3946114d715f1e5b
schema:url	https://doi.org/10.1111/j.1365-2958.2011.07553.x
resource representing a document's title	GI-type T4SS-mediated horizontal transfer of the 89K pathogenicity island in epidemic Streptococcus suis serotype 2
has PubMed Central identifier	PMC3132442
has PubMed identifier	21244532
schema:publication	Mol Microbiol
resource representing a document's body	covid:7212e4cdbb493aa171b9d07c3946114d715f1e5b#body_text
is schema:about of	named entity 'TYPE IV SECRETION SYSTEM' named entity 'EVENTS' named entity 'ITS' named entity 'SITE-SPECIFIC RECOMBINATION' named entity 'POSITIVE' named entity 'CIRCULAR' named entity 'DONOR' named entity 'REPORT' named entity 'IS A' named entity 'CHINA' named entity 'DISTINCT' named entity 'PAI' named entity 'RAPID' named entity 'TO FORM' named entity 'MOBILIZATION' named entity 'RECENT' named entity 'MEDIATED' named entity 'PATHOGENS' named entity 'SPREAD' named entity 'HELP' named entity 'genetic' named entity 'target' named entity 'spontaneously' named entity 'circular' named entity 'Streptococcus' named entity 'TYPE' named entity 'INTERMEDIATE' named entity 'DEMONSTRATION' named entity 'PRECISE' named entity 'SPONTANEOUSLY' named entity 'NEWLY' named entity 'CONJUGAL TRANSFER' named entity 'OCCURRED' named entity 'EMERGENCE' named entity 'INTEGRASE' named entity 'EXCISIONASE' named entity 'CONTRIBUTION' named entity 'ENCODED' named entity 'RELATED' named entity 'PLAY' named entity 'POTENTIAL' named entity 'UNKNOWN' named entity 'INVESTIGATED' named entity 'PATHOGENICITY ISLAND' named entity 'MEDIATED' named entity 'TRANSFER' named entity '1670' named entity 'HORIZONTAL' named entity 'EPIDEMIC' named entity 'GRAM-' named entity 'S. SUIS 2' named entity 'PATHOGENICITY ISLANDS' named entity 'EPIDEMIC' named entity 'LATERAL' named entity 'EVOLUTION' named entity 'TYPE' named entity 'ACTS' named entity 'TRANSFER' named entity 'IMPORTANT' named entity 'SUBSTRATE' named entity 'HORIZONTAL' named entity 'EXCISION' named entity 'OUTBREAKS' named entity 'STUDY' named entity 'NON-' named entity 'INFECTION' named entity 'STREPTOCOCCUS SUIS' named entity 'MECHANISM' named entity 'TARGET SITE'

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