About: COVID-19-related acute necrotizing encephalopathy with brain stem involvement in a patient with aplastic anemia

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About: COVID-19-related acute necrotizing encephalopathy with brain stem involvement in a patient with aplastic anemia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	COVID-19-related acute necrotizing encephalopathy with brain stem involvement in a patient with aplastic anemia
Creator	Nicholas, Richard Dixon, Luke Everitt, Alex Gontsarova, Anastassia Jenkins, Harri Jones, Brynmor Luqmani, Asad Mallon, D Mallon, Dermot Muir, David Tona, Francesca Varley, James
Source	Medline; PMC
abstract	OBJECTIVE: To describe a novel case of coronavirus disease 2019 (COVID-19)-associated acute necrotizing encephalopathy (ANE) in a patient with aplastic anemia where there was early brain stem-predominant involvement. METHODS: Evaluation of cause, clinical symptoms, and treatment response. RESULTS: A 59-year-old woman with a background of transfusion-dependent aplastic anemia presented with seizures and reduced level of consciousness 10 days after the onset of subjective fever, cough, and headache. Nasopharyngeal swab testing for severe acute respiratory syndrome coronavirus (SARS-CoV-2) was positive, and CT during admission demonstrated diffuse swelling of the brain stem. She required intubation and mechanical ventilation for airway protection, given her reduced level of consciousness. The patient's condition deteriorated, and MRI on day 6 demonstrated worsening brain stem swelling with symmetrical hemorrhagic lesions in the brain stem, amygdalae, putamina, and thalamic nuclei. Appearances were consistent with hemorrhagic ANE with early brain stem involvement. The patient showed no response to steroid therapy and died on the eighth day of admission. CONCLUSIONS: COVID-19 may be associated with an acute severe encephalopathy and, in this case, was considered most likely to represent an immune-mediated phenomenon. As the pandemic continues, we anticipate that the spectrum of neurologic presentation will broaden. It will be important to delineate the full clinical range of emergent COVID-19-related neurologic disease.
has issue date	2020-05-26(xsd:dateTime)
bibo:doi	10.1212/nxi.0000000000000789
bibo:pmid	32457227
has license	cc-by-nc-nd
sha1sum (hex)	71e84aa077325148da60c99879c057ed96241a62
schema:url	https://doi.org/10.1212/nxi.0000000000000789
resource representing a document's title	COVID-19-related acute necrotizing encephalopathy with brain stem involvement in a patient with aplastic anemia
has PubMed Central identifier	PMC7286661
has PubMed identifier	32457227
schema:publication	Neurol Neuroimmunol Neuroinflamm
resource representing a document's body	covid:71e84aa077325148da60c99879c057ed96241a62#body_text
is schema:about of	named entity 'patient' named entity 'coronavirus disease 2019' named entity 'COVID' named entity 'human population' named entity 'swelling of the brain' named entity 'pathology' named entity 'aplastic anemia' named entity 'necrotic lesions' named entity 'prognosis' named entity 'protein' named entity 'ventricles' named entity 'severe swelling' named entity 'neurologic' named entity 'emergency department' named entity 'GTCS' named entity 'pontine hemorrhage' named entity 'white cell count' named entity 'CSF' named entity 'platelets' named entity 'COVID' named entity 'Nasopharyngeal swab' named entity 'Total bilirubin' named entity 'uncal herniation' named entity 'respiratory symptoms' named entity 'tonsillar herniation' named entity 'neutrophil' named entity 'lumbar puncture' named entity 'neurologic manifestations' named entity 'consciousness' named entity 'immunosuppressant therapy' named entity 'amygdalae' named entity 'symptom' named entity 'amygdalae' named entity 'clarithromycin' named entity 'mm Hg' named entity 'aplastic anemia' named entity 'blood pressure' named entity 'consciousness' named entity 'mechanical ventilation' named entity 'single case' named entity 'brain stem' named entity 'airway' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'flexion' named entity 'sore throat' named entity 'levetiracetam' named entity 'reported cases' named entity 'tonic-clonic seizure' named entity 'myalgia' named entity 'white blood cell count' named entity 'reported cases' named entity 'platelet count' named entity 'CSF analysis' named entity 'leukopenia' named entity 'HLA' named entity 'cytomegalovirus' named entity 'white cell count' named entity 'CT scan' named entity 'mycoplasma' named entity 'ambient air' named entity 'COVID' named entity 'amygdalae' named entity 'seizures' named entity 'PCR' named entity 'sequelae' named entity 'infratentorial' named entity 'emergency department' named entity 'GCS' named entity 'hemorrhage' named entity 'enterovirus'

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