About: Fibrinolysis Shutdown Correlates to Thromboembolic Events in Severe COVID-19 Infection

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Fibrinolysis Shutdown Correlates to Thromboembolic Events in Severe COVID-19 Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Fibrinolysis Shutdown Correlates to Thromboembolic Events in Severe COVID-19 Infection
Creator	Moore, Peter Mcintyre, Robert Moore, Ernest Moore, Hunter Nydam, Trevor Urban, Shane Wright, Franklin Wohlauer, Max Vogler, Thomas
Source	Elsevier; Medline; PMC; WHO
abstract	BACKGROUND: Coronavirus disease 2019 (COVID-19) predisposes patients to a prothrombotic state with demonstrated microvascular involvement. The degree of hypercoagulability appears to correlate with outcomes, however optimal criteria to assess for the highest risk patients for thrombotic events remain unclear; we hypothesized that deranged thromboelastography (TEG) measurements of coagulation would correlate with thromboembolic events. METHODS: Patients admitted to an intensive care unit with COVID-19 diagnoses that had TEG analyses performed were studied. Conventional coagulation assays, D-dimer levels, and viscoelastic parameters were analyzed using a receiver operating characteristic curve to predict thromboembolic outcomes and new onset renal failure. RESULTS: Forty-four patients with COVID-19 were included in the analysis. Derangements in coagulation laboratory values including elevated D-Dimer, fibrinogen, PT, and PTT were confirmed; viscoelastic parameters showed an elevated maximum amplitude and low lysis at 30 minutes. A complete lack of lysis of clot at 30 minutes was seen in 57% of patients and predicted VTE with an AUROC of .742 (p=0.021). A D-Dimer cutoff of 2600 ng/ml predicted need for dialysis with an AUROC of .779 (p=0.005). Overall, patients with no lysis of clot at 30 minutes and a D-Dimer of greater than 2600 ng/ml had a rate of VTE of 50% compared to 0% for patients with neither risk factor (p=0.008) and had a hemodialysis rate of 80% compared to 14% (p=0.004). CONCLUSIONS: Fibrinolysis shutdown, as evidenced by elevated D-Dimer and complete failure of clot lysis at 30 minutes on thromboelastography, predicts thromboembolic events and need for hemodialysis in critically ill patients with COVID-19. Further clinical trials are required to ascertain the need for early therapeutic anticoagulation or fibrinolytic therapy to address this state of fibrinolysis shutdown.
has issue date	2020-05-15(xsd:dateTime)
bibo:doi	10.1016/j.jamcollsurg.2020.05.007
bibo:pmid	32422349
has license	no-cc
sha1sum (hex)	71480d51449adc0ef61429a8f5350e460835dd39
schema:url	https://doi.org/10.1016/j.jamcollsurg.2020.05.007
resource representing a document's title	Fibrinolysis Shutdown Correlates to Thromboembolic Events in Severe COVID-19 Infection
has PubMed Central identifier	PMC7227511
has PubMed identifier	32422349
schema:publication	J Am Coll Surg
resource representing a document's body	covid:71480d51449adc0ef61429a8f5350e460835dd39#body_text
is schema:about of	named entity 'Fibrinolysis' named entity 'PATIENTS' named entity 'PRE' named entity 'SEVERE COVID-19 INFECTION' named entity 'ASSOCIATED' named entity 'Coronavirus disease 2019' named entity 'Coronavirus disease 2019' named entity 'thromboelastography' named entity 'coagulation' named entity 'Fibrinolysis' named entity 'Infection' named entity 'degree' named entity 'Italy' named entity 'stroke' named entity 'mechanical ventilation' named entity 'growing exponentially' named entity 'thromboelastography' named entity 'fibrinolysis' named entity 'acute respiratory distress syndrome' named entity 'sensitivity and specificity' named entity 'thrombotic complications' named entity 'anticoagulation' named entity 'SOFA score' named entity 'hypercoagulability' named entity 'fibrinolysis' named entity 'ICU' named entity 'hypercoagulability' named entity 'thrombotic events' named entity 'D-dimer' named entity 'acute respiratory distress syndrome' named entity 'Clotting' named entity 'VTE' named entity 'fibrinolytic' named entity 'VTE' named entity 'coagulation' named entity 'H1N1' named entity 'hypercoagulable' named entity 'fibrinolysis' named entity 'oxygen' named entity 'anticoagulation' named entity 'anticoagulation' named entity 'thrombosis' named entity 'fibrinolysis' named entity 'hypercoagulable state' named entity 'coronavirus' named entity 'intensive care unit' named entity 'thrombotic stroke' named entity 'VTE' named entity 'COVID-19' named entity 'COVID-19' named entity 'aPTT' named entity 'coagulation' named entity 'medical therapy' named entity 'DIC' named entity 'tranexamic acid' named entity 'thrombotic complications' named entity 'dialysis' named entity 'receiver operating characteristic' named entity 'fibrinogen' named entity 'VTE' named entity 'trauma patients' named entity 'renal failure' named entity 'INR' named entity 'disease processes' named entity 'receiver operating characteristic' named entity 'viscoelastic' named entity 'D-Dimer' named entity 'COVID' named entity 'thromboses' named entity 'thromboembolic' named entity 'coagulation' named entity 'fibrin degradation products' named entity 'central lines'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software