About: Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT

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About: Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT
Creator	Chen, Jung-Chou Chen, Ming-Ho Chuang, Jing-Jing Lee, Ming-Yang Li, Yi-Zhen Liu, Yi-Wen Ning, Sin-Tzu
source	PMC
abstract	Although hepatitis C virus (HCV) affects approximately 130–170 million people worldwide, no vaccines are available. HCV is an important cause of chronic hepatitis, cirrhosis and hepatocellular carcinoma, leading to the need for liver transplantation. In this study, curcumin, a constituent used in traditional Chinese medicine, has been evaluated for its anti-HCV activity and mechanism, using a human hepatoma cell line containing the HCV genotype 1b subgenomic replicon. Below the concentration of 20% cytotoxicity, curcumin dose-dependently inhibited HCV replication by luciferase reporter gene assay, HCV RNA detection and HCV protein analysis. Under the same conditions, curcumin also dose-dependently induced heme oxygenase-1 with the highest induction at 24 h. Hemin, a heme oxygenase-1 inducer, also inhibited HCV protein expression in a dose-dependent manner. The knockdown of heme oxygenase-1 partially reversed the curcumin-inhibited HCV protein expression. In addition to the heme oxygenase-1 induction, signaling molecule activities of AKT, extracellular signal-regulated kinases (ERK) and nuclear factor-κB (NF-κB) were inhibited by curcumin. Using specific inhibitors of PI3K-AKT, MEK-ERK and NF-κB, the results suggested that only PI3K-AKT inhibition is positively involved in curcumin-inhibited HCV replication. Inhibition of ERK and NF-κB was likely to promote HCV protein expression. In summary, curcumin inhibited HCV replication by heme oxygenase-1 induction and AKT pathway inhibition. Although curcumin also inhibits ERK and NF-κB activities, it slightly increased the HCV protein expression. This result may provide information when curcumin is used as an adjuvant in anti-HCV therapy.
has issue date	2012-08-20(xsd:dateTime)
bibo:doi	10.3892/ijmm.2012.1096
bibo:pmid	22922731
has license	cc-by
sha1sum (hex)	70fefc54856d09f01cb983932a860dc4dacb9f46
schema:url	https://doi.org/10.3892/ijmm.2012.1096
resource representing a document's title	Curcumin inhibits HCV replication by induction of heme oxygenase-1 and suppression of AKT
has PubMed Central identifier	PMC3573749
has PubMed identifier	22922731
schema:publication	Int J Mol Med
resource representing a document's body	covid:70fefc54856d09f01cb983932a860dc4dacb9f46#body_text
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