About: Identification of Potential Vaccine Candidates Against Streptococcus pneumoniae by Reverse Vaccinology Approach

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Identification of Potential Vaccine Candidates Against Streptococcus pneumoniae by Reverse Vaccinology Approach
Creator	Kumar, Parveen Prashanth, K Saikia, Kandarpa Talukdar, Sandipan Zutshi, Shubhranshu
Source	Medline; PMC
abstract	In the past few decades, genome-based approaches have contributed significantly to vaccine development. Our aim was to identify the most conserved and immunogenic antigens of Streptococcus pneumoniae, which can be potential vaccine candidates in the future. BLASTn was done to identify the most conserved antigens. PSORTb 3.0.2 was run to predict the subcellular localization of the proteins. B cell epitope prediction was done for the immunogenicity testing. Finally, BLASTp was done for verifying the extent of similarity to human proteome to exclude the possibility of autoimmunity. Proteins failing to comply with the set parameters were filtered at each step. Based on the above criteria, out of the initial 22 pneumococcal proteins selected for screening, pavB and pullulanase were the most promising candidate proteins.
has issue date	2014-01-31(xsd:dateTime)
bibo:doi	10.1007/s12010-014-0749-x
bibo:pmid	24482282
has license	no-cc
sha1sum (hex)	7074b1e9005a03566e4b4e849bb7b69a8ffd114f
schema:url	https://doi.org/10.1007/s12010-014-0749-x
resource representing a document's title	Identification of Potential Vaccine Candidates Against Streptococcus pneumoniae by Reverse Vaccinology Approach
has PubMed Central identifier	PMC7090528
has PubMed identifier	24482282
schema:publication	Appl Biochem Biotechnol
resource representing a document's body	covid:7074b1e9005a03566e4b4e849bb7b69a8ffd114f#body_text
is schema:about of	named entity 'potential' named entity 'pneumococcal' named entity 'future' named entity 'antigens' named entity 'Our' named entity 'IMMUNOGENIC' named entity 'CONSERVED' named entity 'IMMUNOGENICITY' named entity 'POTENTIAL' named entity 'SIMILARITY' named entity '0.2' named entity 'EXTENT OF' named entity 'BLASTN' named entity 'IDENTIFICATION' named entity 'APPROACH' named entity 'INITIAL' named entity 'HUMAN' named entity 'VACCINE' named entity 'STREPTOCOCCUS PNEUMONIAE' named entity 'TO IDENTIFY' named entity 'PNEUMOCOCCAL' named entity 'AUTOIMMUNITY' named entity 'VERIFYING' named entity 'PREDICT' named entity 'CRITERIA' named entity 'VACCINE' named entity 'SELECTED' named entity 'TESTING' named entity 'PULLULANASE' named entity 'POTENTIAL' named entity 'POSSIBILITY OF' named entity 'GENOME' named entity 'FUTURE' named entity 'EXCLUDE' named entity 'COMPLY' named entity 'ANTIGENS' named entity 'STEP' named entity 'BASED' named entity 'FILTERED' named entity 'SCREENING' named entity 'STREPTOCOCCUS PNEUMONIAE' named entity 'B CELL EPITOPE PREDICTION' named entity 'PROTEINS' named entity 'AIM' named entity 'RUN' named entity 'SUBCELLULAR LOCALIZATION' named entity 'FAILING' named entity 'PROTEOME' named entity 'CANDIDATE' named entity 'APPROACHES' named entity 'SET PARAMETERS' named entity 'VACCINE DEVELOPMENT' named entity 'OUR' named entity 'HAVE' named entity 'IN THE PAST' named entity 'conserved' named entity 'identify' named entity 'proteins' named entity 'set' named entity 'candidate' named entity 'Potential' named entity 'subcellular localization' named entity 'autoimmunity' named entity 'immunogenicity' named entity 'proteome' named entity 'Streptococcus pneumoniae' named entity 'Reverse Vaccinology' named entity 'Streptococcus pneumoniae' named entity 'immunogenicity' named entity 'interact' named entity 'hyaluronidase' named entity 'cross-validation' named entity 'vaccine' named entity 'group B streptococcus' named entity 'cytoplasmic membrane' named entity 'cell surface proteins' named entity 'autoimmunity'

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