About: Aurintricarboxylic acid inhibits influenza virus neuraminidase

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Aurintricarboxylic acid inhibits influenza virus neuraminidase
Creator	Chao, Yu-Sheng Shih, Shin-Ru Tseng, Sung-Nain Yang, Jinn-Moon Hsieh, Hsing-Pang Hung, Hui-Chen Hsu, T.-A Chen, Yen-Fu Ju, Yi-Wei Tseng, Ching-Ping
Source	Elsevier; Medline; PMC
abstract	Abstract There is a continuing threat that the highly pathogenic avian influenza virus will cause future influenza pandemics. In this study, we screened a library of compounds that are biologically active and structurally diverse for inhibitory activity against influenza neuraminidase (NA). We found that aurintricarboxylic acid (ATA) is a potent inhibitor of NA activity of both group-1 and group-2 influenza viruses with IC50s (effective concentration to inhibit NA activity by 50%) values at low micromolar concentrations. ATA was equally potent in inhibiting the NA activity derived from wild-type NA and its H274Y mutant which renders NA resistance to inhibition by oseltamivir. Although ATA is structurally distinct from sialic acid, molecular modeling experiments suggested that ATA binds to NA at the enzyme’s substrate binding site. These results indicate that ATA may be a good starting material for the design of a novel class of NA inhibitors for the treatment influenza viruses.
has issue date	2009-02-28(xsd:dateTime)
bibo:doi	10.1016/j.antiviral.2008.10.006
bibo:pmid	19014974
has license	els-covid
sha1sum (hex)	7020b3b0ef1ba1aa192d2474f6baa2bed9514a9b
schema:url	https://doi.org/10.1016/j.antiviral.2008.10.006
resource representing a document's title	Aurintricarboxylic acid inhibits influenza virus neuraminidase
has PubMed Central identifier	PMC7114187
has PubMed identifier	19014974
schema:publication	Antiviral Research
resource representing a document's body	covid:7020b3b0ef1ba1aa192d2474f6baa2bed9514a9b#body_text
is schema:about of	named entity 'pandemics' named entity 'mutant' named entity '50%' named entity 'FUTURE' named entity 'INFLUENZA VIRUSES' named entity 'CLASS' named entity 'ACTIVE' named entity 'DIVERSE' named entity 'SIALIC ACID' named entity 'ACTIVITY' named entity 'NOVEL' named entity 'CONTINUING' named entity 'INFLUENZA NEURAMINIDASE' named entity 'DESIGN' named entity 'STARTING MATERIAL' named entity 'ENZYME' named entity 'HIGHLY PATHOGENIC AVIAN INFLUENZA VIRUS' named entity 'OSELTAMIVIR' named entity 'AURINTRICARBOXYLIC ACID' named entity 'INFLUENZA VIRUS NEURAMINIDASE' named entity 'PANDEMICS' named entity 'CONCENTRATION' named entity 'DERIVED' named entity 'ITS' named entity '27S' named entity 'MUTANT' named entity 'INHIBITING' named entity 'DISTINCT FROM' named entity 'WILD-TYPE' named entity 'BINDS' named entity 'MOLECULAR MODELING' named entity 'INHIBITORY ACTIVITY' named entity 'INFLUENZA' named entity 'BIOLOGICALLY' named entity 'SUBSTRATE BINDING SITE' named entity 'THREAT' named entity 'TO INHIBIT' named entity 'IS A' named entity 'STUDY' named entity 'FOUND' named entity 'INHIBITION' named entity 'GOOD' named entity 'MICROMOLAR' named entity 'MAY BE A' named entity 'LOW' named entity 'GROUP' named entity 'VALUES' named entity 'EXPERIMENTS' named entity 'LIBRARY' named entity 'THESE' named entity 'RESISTANCE TO' named entity 'AURINTRICARBOXYLIC ACID' named entity 'ATA' named entity 'INHIBITOR' named entity 'CAUSE' named entity 'RESULTS' named entity 'TREATMENT' covid:arg/7020b3b0ef1ba1aa192d2474f6baa2bed9514a9b named entity 'influenza' named entity 'inhibitors' named entity 'neuraminidase' named entity 'binding site' named entity 'micromolar' named entity 'inhibitory' named entity 'H5N1' named entity 'IGF-I' named entity 'H5N1' named entity 'hydrophobic interactions' named entity 'chemiluminescence' named entity 'respiratory illness' named entity 'plaque formation' named entity 'ATA'

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