About: Effects of mechanical ventilation with different tidal volume on oxidative stress and antioxidant in lung

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Effects of mechanical ventilation with different tidal volume on oxidative stress and antioxidant in lung
Creator	Li, · Cao, Ya-Nan Han, Xue-Ping Miao, -Jun Ren, Su-En Sun, Xue-Qing Sun, Zhen-Tao Yang, Chun-Yao Zhang, Shan-Feng
Source	PMC
abstract	PURPOSE: The aim of this study was to investigate the changes in oxidative stress and antioxidants in lung tissue under different tidal volume ventilation conditions. METHODS: Forty-eight male Wistar rats were randomized into four groups, namely, group C, the control group, which was not ventilated, and groups C1, C2 and C3, the treatment groups, which were ventilated for 2 h with tidal volumes of 8, 30 and 42 ml/kg, respectively. The right middle lobe was assayed for malondialdehyde (MDA), the right posterior lobe was assayed using Western blotting for Nrf2, GCLm and SrX1 and the left lobe was assayed for Nrf2, GCLm and SrX1 mRNA. RESULTS: The MDA levels were increased in the three treatment groups, with MDA levels highest in group C3 and lowest in group C1 (C3 > C2 > C1) (all P < 0.05). The mRNA expression of Nrf2, GCLm and SrX1 was highest in group C3 and lowest in group 1 (C3 > C2 > C1) (all P < 0.05). No significant difference was observed between group C1 and group C (P > 0.05). A Western blot analysis showed that Nrf2, GCLm and SrX1 expression was highest in group C3 and lowest in group C1 (C3 > C2 > C1) (all P < 0.05). No significant difference was observed between group C1 and group C (P > 0.05). CONCLUSIONS: Oxidative stress and antioxidant enzyme levels in the lungs of rats were positively associated with the tidal volumes of mechanical ventilation, suggesting that higher tidal volumes cause more severe oxidative stress and increased antioxidant responses.
has issue date	2014-12-05(xsd:dateTime)
bibo:doi	10.1007/s00540-014-1954-z
bibo:pmid	25475993
has license	no-cc
sha1sum (hex)	6ebf9f45f5d790cb04c1ea7c5af29da9fed23b3a
schema:url	https://doi.org/10.1007/s00540-014-1954-z
resource representing a document's title	Effects of mechanical ventilation with different tidal volume on oxidative stress and antioxidant in lung
has PubMed Central identifier	PMC7102116
has PubMed identifier	25475993
schema:publication	J Anesth
resource representing a document's body	covid:6ebf9f45f5d790cb04c1ea7c5af29da9fed23b3a#body_text
is schema:about of	named entity 'lung' named entity 'Prx' named entity 'GSH' named entity 'volutrauma' named entity 'tidal volume' named entity 'mm Hg' named entity 'ALI' named entity 'high volume' named entity 'control group' named entity 'VILI' named entity 'toxin' named entity 'tidal volume' named entity 'control group' named entity 'JNK' named entity 'Mechanical ventilation' named entity 'pulse oximeter' named entity 'biosynthesis' named entity 'inflammation' named entity 'lungs' named entity 'GCLm' named entity 'β-actin' named entity 'anesthetic' named entity 'antioxidant enzymes' named entity 'antibody' named entity 'tidal volume' named entity 'GCL' named entity 'volutrauma' named entity 'nmol' named entity 'Shanghai' named entity 'γ-glutamylcysteine' named entity 'cellular signaling' named entity 'VILI' named entity 'GCL' named entity 'Zhengzhou University' named entity 'Sulfiredoxin' named entity 'enzyme' named entity 'ventilator' named entity 'PI3' named entity 'GSH' named entity 'ARDS' named entity 'VILI' named entity 'oxidant' named entity 'GCLm' named entity 'Analysis of variance' named entity 'GSH' named entity 'cytosolic' named entity 'glutamate cysteine ligase' named entity 'high volume' named entity 'oxygen concentration' named entity 'protein' named entity 'tidal' named entity 'mechanical ventilation' named entity 'Oxidative stress' named entity 'oxidative stress' named entity 'mechanical ventilation' named entity 'tidal volume' named entity 'antioxidant' named entity 'oxidative stress' named entity '1:500' named entity 'Nrf2' named entity 'Wistar rats' named entity 'GSH' named entity 'Ventilator-induced lung injury' named entity 'invasive blood pressure' named entity 'pathogenesis' named entity 'reverse transcription' named entity 'GCLm' named entity 'tidal volume' named entity 'NFκB' named entity 'treatment groups' named entity 'experimental animal' named entity 'ROS' named entity 'China'

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