About: A Role for IFITM Proteins in Restriction of Mycobacterium tuberculosis Infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	A Role for IFITM Proteins in Restriction of Mycobacterium tuberculosis Infection
Creator	Haridas, Viraga Ranjbar, Shahin Falvo, James Goldfeld, Anne Jasenosky, Luke
source	Medline; PMC
abstract	The interferon (IFN)-induced transmembrane (IFITM) proteins are critical mediators of the host antiviral response. Here, we expand the role of IFITM proteins to host defense against intracellular bacterial infection by demonstrating that they restrict Mycobacterium tuberculosis (MTb) intracellular growth. Simultaneous knockdown of IFITM1, IFITM2, and IFITM3 by RNAi significantly enhances MTb growth in human monocytic and alveolar/epithelial cells, whereas individual overexpression of each IFITM impairs MTb growth in these cell types. Furthermore, MTb infection, Toll-like receptor 2 and 4 ligands, and several proinflammatory cytokines induce IFITM1–3 gene expression in human myeloid cells. We find that IFITM3 co-localizes with early and, in particular, late MTb phagosomes, and overexpression of IFITM3 enhances endosomal acidification in MTb-infected monocytic cells. These findings provide evidence that the antiviral IFITMs participate in the restriction of mycobacterial growth, and they implicate IFITM-mediated endosomal maturation in its antimycobacterial activity.
has issue date	2015-10-22(xsd:dateTime)
bibo:doi	10.1016/j.celrep.2015.09.048
bibo:pmid	26565900
has license	cc-by-nc-nd
sha1sum (hex)	6e1cd91f28e6a422438a943b5ef37b9911ddad2c
schema:url	https://doi.org/10.1016/j.celrep.2015.09.048
resource representing a document's title	A Role for IFITM Proteins in Restriction of Mycobacterium tuberculosis Infection
has PubMed Central identifier	PMC4916766
has PubMed identifier	26565900
schema:publication	Cell Rep
resource representing a document's body	covid:6e1cd91f28e6a422438a943b5ef37b9911ddad2c#body_text
is schema:about of	named entity 'MYCOBACTERIUM TUBERCULOSIS INFECTION' named entity 'FINDINGS' named entity 'PHAGOSOMES' named entity 'TOLL-LIKE RECEPTOR 2' named entity 'MATURATION' named entity 'LIGANDS' named entity 'RNAI' named entity 'PARTICULAR' named entity 'CELL TYPES' named entity 'MEDIATORS' named entity 'IFITM3' named entity 'PROTEINS' named entity 'MONOCYTIC' named entity 'MYCOBACTERIAL' named entity 'BACTERIAL INFECTION' named entity 'MTB' named entity 'HOST DEFENSE' named entity 'EARLY' named entity 'MYELOID CELLS' named entity 'ALVEOLAR' named entity 'human' named entity 'MTb' named entity 'phagosomes' named entity 'maturation' named entity 'IFITM1' named entity 'SIMULTANEOUS' named entity 'INFECTED' named entity 'RESTRICTION' named entity 'TRANSMEMBRANE' covid:arg/6e1cd91f28e6a422438a943b5ef37b9911ddad2c named entity 'ROLE' named entity 'INTRACELLULAR' named entity 'ANTIMYCOBACTERIAL ACTIVITY' named entity 'INDUCE' named entity 'INFECTION' named entity 'OF EACH' named entity 'CRITICAL' named entity 'PROINFLAMMATORY CYTOKINES' named entity 'PROTEINS' named entity 'RESTRICTION' named entity 'LATE' named entity 'IFITM2' named entity 'EXPAND' named entity 'HERE' named entity 'INDIVIDUAL' named entity 'ACIDIFICATION' named entity 'INDUCED' named entity 'MEDIATED' named entity 'HUMAN' named entity 'EVIDENCE' named entity 'MYCOBACTERIUM TUBERCULOSIS' named entity 'OVEREXPRESSION' named entity 'CELLS' named entity 'THESE' named entity 'GENE EXPRESSION' named entity 'HOST' named entity 'ROLE' named entity 'INTERFERON ' named entity 'ANTIVIRAL RESPONSE' named entity 'RESTRICT' named entity 'ITS' named entity 'ANTIVIRAL' named entity 'PROVIDE' named entity 'IMPAIRS' named entity 'GROWTH' named entity 'myeloid' named entity 'endosomal' named entity 'host defense' named entity 'Toll-like receptor' named entity 'antiviral activity' named entity 'IFITM1' named entity 'lentiviral particles' named entity 'IL-6' named entity 'bacterial growth' named entity 'viral pathogens' named entity 'infection' named entity 'A549'

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