About: Antiviral and Anti-Inflammatory Activities of Pochonin D, a Heat Shock Protein 90 Inhibitor, against Rhinovirus Infection

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About: Antiviral and Anti-Inflammatory Activities of Pochonin D, a Heat Shock Protein 90 Inhibitor, against Rhinovirus Infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Antiviral and Anti-Inflammatory Activities of Pochonin D, a Heat Shock Protein 90 Inhibitor, against Rhinovirus Infection
Creator	Ahn, Jae-Hee Chang, Sun-Young Kim, Yeon-Jeong Ko, Hyun-Jeong Kwon, Bo-Eun Lee, Jongkook Shim, Aeri Song, Jae-Hyoung Pham, Thuy
Source	PMC
abstract	Human rhinoviruses (HRV) are one of the major causes of common cold in humans and are also associated with acute asthma and bronchial illness. Heat-shock protein 90 (Hsp90), a molecular chaperone, is an important host factor for the replication of single-strand RNA viruses. In the current study, we examined the effect of the Hsp90 inhibitor pochonin D, in vitro and in vivo, using a murine model of human rhinovirus type 1B (HRV1B) infection. Our data suggested that Hsp90 inhibition significantly reduced the inflammatory cytokine production and lung damage caused by HRV1B infection. The viral titer was significantly lowered in HRV1B-infected lungs and in Hela cells upon treatment with pochonin D. Infiltration of innate immune cells including granulocytes and monocytes was also reduced in the bronchoalveolar lavage (BAL) by pochonin D treatment after HRV1B infection. Histological analysis of the lung and respiratory tract showed that pochonin D protected the mice from HRV1B infection. Collectively, our results suggest that the Hsp90 inhibitor, pochonin D, could be an attractive antiviral therapeutic for treating HRV infection.
has issue date	2018-05-02(xsd:dateTime)
bibo:doi	10.4062/biomolther.2017.233
bibo:pmid	29715717
has license	cc-by-nc
sha1sum (hex)	6d6294ef224683962e08a1059ea4b027b769e5ed
schema:url	https://doi.org/10.4062/biomolther.2017.233
resource representing a document's title	Antiviral and Anti-Inflammatory Activities of Pochonin D, a Heat Shock Protein 90 Inhibitor, against Rhinovirus Infection
has PubMed Central identifier	PMC6254639
has PubMed identifier	29715717
schema:publication	Biomol Ther (Seoul)
resource representing a document's body	covid:6d6294ef224683962e08a1059ea4b027b769e5ed#body_text
is schema:about of	named entity 'BRONCHIAL' named entity 'REDUCED' named entity 'ILLNESS' named entity 'HSP90' named entity 'POCHONIN D' named entity 'IMMUNE CELLS' named entity 'HOST FACTOR' named entity 'MURINE' named entity 'TREATMENT AFTER' named entity 'ANTIVIRAL' named entity 'ATTRACTIVE' named entity 'VIRAL TITER' named entity 'REPLICATION' named entity 'BRONCHOALVEOLAR LAVAGE' named entity 'RNA VIRUSES' named entity 'monocytes' named entity 'protein' named entity 'vivo' named entity 'bronchoalveolar lavage' named entity 'antiviral' named entity 'Rhinovirus' named entity 'Infection' covid:arg/6d6294ef224683962e08a1059ea4b027b769e5ed named entity 'STUDY' named entity 'COULD BE' named entity 'LUNG' named entity 'MICE' named entity 'RESPIRATORY TRACT' named entity 'LUNGS' named entity 'IMPORTANT' named entity 'HEAT-SHOCK PROTEIN' named entity 'IN VIVO' named entity 'INCLUDING' named entity 'ACUTE ASTHMA' named entity 'TREATING' named entity 'ANTI-INFLAMMATORY' named entity 'RHINOVIRUS INFECTION' named entity 'POCHONIN D' named entity 'HUMAN' named entity 'ONE OF' named entity 'CAUSES' named entity 'RESULTS' named entity 'COMMON COLD' named entity 'INFLAMMATORY CYTOKINE' named entity 'MAJOR' named entity 'HUMANS' named entity 'MOLECULAR CHAPERONE' named entity 'EXAMINED' named entity 'IN VITRO' named entity 'INFECTED' named entity 'USING' named entity 'SUGGEST' named entity 'DATA' named entity 'LOWERED' named entity 'ANTIVIRAL' named entity 'HEAT SHOCK PROTEIN 90 INHIBITOR' named entity 'CURRENT' named entity 'PROTEIN ' named entity 'TREATMENT' named entity 'DAMAGE' named entity 'HISTOLOGICAL ANALYSIS' named entity 'THERAPEUTIC' named entity 'TYPE 1B' named entity 'ACTIVITIES' named entity 'ASSOCIATED WITH' named entity 'GRANULOCYTES' named entity 'HELA CELLS' named entity 'MONOCYTES' named entity 'INHIBITION' named entity 'MODEL OF' named entity 'HUMAN RHINOVIRUS' named entity 'OUR' named entity 'CYTOKINE PRODUCTION'

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