About: Comparison of Fresh and Room-Aged Cigarette Sidestream Smoke in a Subchronic Inhalation Study on Rats

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Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Comparison of Fresh and Room-Aged Cigarette Sidestream Smoke in a Subchronic Inhalation Study on Rats
Creator	Anskeit, Erwin Becker, E Haussmann, H.-J Haussmann, Hans-Jiirgen Kuhl, Peter Stinn, P Stinn, Walter Teredesai, Ashok Teredesai, W Voncken, Peter Walk, Riidiger-Alexander
Source	PMC
abstract	Two experimental types of cigarette sidestream smoke (SS) were compared in a subchronic inhalation study on rats. Fresh SS (FSS) was generated continuously from the reference cigarette 2R1. Room-aged SS (RASS) was generated by aging FSS for 1.5 h in a room with noninert surfaces with materials typically found in residences or offices. Male Sprague-Dawley rats were head-only exposed to three dose levels of each SS type and to filtered, conditioned fresh air (sham-exposure) for 6 h/day, 7 days/week, for 90 days. Room-aging resulted in decreased concentrations of various SS components, e.g., total participate matter (TPM) and nicotine, while other components, such as carbon monoxide (CO), were not affected. The CO concentrations were 6, 13, and 28 ppm for both SS types. TPM concentrations were between 0.6 and 8.7 (μg/liter and thus up to 100-fold above the maximum of average concentrations of respiratory suspended particles reported for environmental tobacco smoke. Slight reserve cell hyperplasia in the anterior part of the nose as well as hyperplastic and metaplastic epithelial changes in the larynx were the only observed dose-dependent findings. The metabolism of benzo(a)-pyrene-as a proxy for polycyclic aromatic hydrocarbon metabolism-was induced in the nasal respiratory epithelium and in the lungs while no effect was seen in the nasal olfactory epithelium. The lowest-observed effect level was 6 ppm CO or 0.6 μg TPM/liter. Most of the effects seen were less expressed in RASS- than in FSS-exposed rats when compared on the basis of the CO concentrations. When compared on the basis of TPM, these effects were equally pronounced for both SS types, suggesting a major role of particulate matter-associated compounds. All findings reverted to sham control levels following a 42-day postinhalation period.
has issue date	1998-01-01(xsd:dateTime)
bibo:doi	10.1093/toxsci/41.1.100
bibo:pmid	9520345
has license	no-cc
sha1sum (hex)	6b904620f0e13408111de49f5060e6ea49fa83ee
schema:url	https://doi.org/10.1093/toxsci/41.1.100
resource representing a document's title	Comparison of Fresh and Room-Aged Cigarette Sidestream Smoke in a Subchronic Inhalation Study on Rats
has PubMed Central identifier	PMC7108658
has PubMed identifier	9520345
schema:publication	Toxicol Sci
resource representing a document's body	covid:6b904620f0e13408111de49f5060e6ea49fa83ee#body_text
is schema:about of	named entity 'Study' named entity 'Smoke' named entity 'Cigarette' named entity 'Inhalation' named entity 'cigarette' named entity 'necropsy' named entity 'isoenzyme' named entity 'acetaldehyde' named entity 'HbCO' named entity 'rat' named entity 'rat' named entity 'statistically significant' named entity 'histopathological' named entity 'sidestream smoke' named entity 'gas-phase' named entity 'nicotine' named entity 'rat' named entity 'respiratory tract' named entity '3-methylcholanthrene' named entity '2E1' named entity 'hematoxylin and eosin' named entity 'infrared' named entity 'epithelia' named entity 'depression' named entity 'pneumonia' named entity 'surface area' named entity 'metabolism' named entity 'metabolism' named entity 'rubber' named entity 'aging-related' named entity 'larynx' named entity 'Ammonia' named entity 'biomarker' named entity 'lungs' named entity 'metabolism' named entity 'statistically significant' named entity 'histopathological' named entity 'alveolar region' named entity 'mice' named entity 'endothelial cells' named entity 'vocal cords' named entity 'body weight' named entity 'rat' named entity 'histopathology' named entity 'intratracheal instillation' named entity 'glucose-6-phosphate' named entity 'glass tubing' named entity 'phenobarbital' named entity 'ppm' named entity 'cytochrome P450 1A1' named entity 'histopathological' named entity 'metabolism' named entity 'diol' named entity 'nicotine' named entity 'lungs' named entity 'respiratory tract' named entity 'lung' named entity 'gas phase' named entity 'gas chromatography' named entity '2.2' named entity 'acrolein' named entity '1.2' named entity 'metabolism' named entity 'nitric oxide' named entity 'epithelial' named entity 'testes' named entity 'pathologist' named entity 'Acetaldehyde' named entity 'Bensheim' named entity 'Germany' named entity 'Sears'

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