About: A Non-VH1-69 Heterosubtypic Neutralizing Human Monoclonal Antibody Protects Mice against H1N1 and H5N1 Viruses

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: A Non-VH1-69 Heterosubtypic Neutralizing Human Monoclonal Antibody Protects Mice against H1N1 and H5N1 Viruses Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Non-VH1-69 Heterosubtypic Neutralizing Human Monoclonal Antibody Protects Mice against H1N1 and H5N1 Viruses
Creator	Marco, De Moreno, L Solforosi, N Clementi, D Mancini, N
Source	PMC
abstract	Influenza viruses are among the most important human pathogens and are responsible for annual epidemics and sporadic, potentially devastating pandemics. The humoral immune response plays an important role in the defense against these viruses, providing protection mainly by producing antibodies directed against the hemagglutinin (HA) glycoprotein. However, their high genetic variability allows the virus to evade the host immune response and the potential protection offered by seasonal vaccines. The emergence of resistance to antiviral drugs in recent years further limits the options available for the control of influenza. The development of alternative strategies for influenza prophylaxis and therapy is therefore urgently needed. In this study, we describe a human monoclonal antibody (PN-SIA49) that recognizes a highly conserved epitope located on the stem region of the HA and able to neutralize a broad spectrum of influenza viruses belonging to different subtypes (H1, H2 and H5). Furthermore, we describe its protective activity in mice after lethal challenge with H1N1 and H5N1 viruses suggesting a potential application in the treatment of influenza virus infections.
has issue date	2012-04-04(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0034415
bibo:pmid	22496802
has license	cc0
sha1sum (hex)	6b51562f63de5739f2b7ebf5f9c34365ac6ee545
schema:url	https://doi.org/10.1371/journal.pone.0034415
resource representing a document's title	A Non-VH1-69 Heterosubtypic Neutralizing Human Monoclonal Antibody Protects Mice against H1N1 and H5N1 Viruses
has PubMed Central identifier	PMC3319592
has PubMed identifier	22496802
schema:publication	PLoS One
resource representing a document's body	covid:6b51562f63de5739f2b7ebf5f9c34365ac6ee545#body_text
is schema:about of	named entity 'STEM' named entity 'VIRUSES' named entity 'AVAILABLE' named entity 'ITS' named entity 'H1N1' named entity 'STRATEGIES' named entity 'APPLICATION' named entity 'INFLUENZA' named entity 'GENETIC VARIABILITY' named entity 'DESCRIBE' named entity 'EMERGENCE' named entity 'NEEDED' named entity 'LETHAL' named entity 'PROPHYLAXIS' named entity 'VIRUS' named entity 'THEIR' named entity 'VACCINES' named entity 'ANTIBODIES' named entity 'belonging' named entity 'influenza' named entity 'monoclonal antibody' named entity 'application' named entity 'HEMAGGLUTININ' named entity 'CHALLENGE' named entity 'PRODUCING' named entity 'INFLUENZA VIRUSES' named entity 'GLYCOPROTEIN' named entity 'PROVIDING' named entity 'PATHOGENS' named entity 'ALTERNATIVE' named entity 'H5N1' named entity 'RESPONSIBLE' named entity 'ANNUAL' named entity 'SPORADIC' named entity 'YEARS' named entity 'LIMITS' named entity 'PLAYS' named entity 'EPIDEMICS' named entity 'THESE' named entity 'ANTIVIRAL DRUGS' named entity 'ALLOWS' named entity 'MONOCLONAL ANTIBODY' named entity 'MICE' named entity 'H1N1' named entity 'VH1' named entity 'DIFFERENT' named entity 'RECENT' named entity 'OFFERED' named entity 'DEFENSE' named entity 'SEASONAL' named entity 'RESISTANCE TO' named entity 'BELONGING' named entity 'HIGH' named entity 'ROLE' named entity 'STUDY' named entity 'PANDEMICS' named entity 'OPTIONS' named entity 'INFECTIONS' named entity 'MONOCLONAL ANTIBODY' named entity 'MICE' named entity 'BROAD SPECTRUM' named entity 'IMPORTANT' named entity 'DIRECTED' named entity 'CONSERVED' named entity 'NON-' named entity 'HUMAN' named entity 'VIRUSES' named entity 'H5N1' named entity 'INFLUENZA VIRUS' named entity 'HUMAN' named entity 'REGION' named entity 'DEVELOPMENT' named entity 'ACTIVITY' named entity 'SUBTYPES' named entity 'POTENTIAL' named entity 'HUMORAL IMMUNE RESPONSE' named entity 'PROTECTION'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software