About: Glutamine antagonist-mediated immune suppression decreases pathology but delays virus clearance in mice during nonfatal alphavirus encephalomyelitis

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About: Glutamine antagonist-mediated immune suppression decreases pathology but delays virus clearance in mice during nonfatal alphavirus encephalomyelitis Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Glutamine antagonist-mediated immune suppression decreases pathology but delays virus clearance in mice during nonfatal alphavirus encephalomyelitis
Creator	Glowinski, Rebecca Baxter, Victoria Griffin, Diane Braxton, Alicia Potter, Michelle Slusher, Barbara
Source	Elsevier; Medline; PMC
abstract	Abstract Infection of weanling C57BL/6 mice with the TE strain of Sindbis virus (SINV) causes nonfatal encephalomyelitis associated with hippocampal-based memory impairment that is partially prevented by treatment with 6-diazo-5-oxo-l-norleucine (DON), a glutamine antagonist (Potter et al., J Neurovirol 21:159, 2015). To determine the mechanism(s) of protection, lymph node and central nervous system (CNS) tissues from SINV-infected mice treated daily for 1 week with low (0.3mg/kg) or high (0.6mg/kg) dose DON were examined. DON treatment suppressed lymphocyte proliferation in cervical lymph nodes resulting in reduced CNS immune cell infiltration, inflammation, and cell death compared to untreated SINV-infected mice. Production of SINV-specific antibody and interferon-gamma were also impaired by DON treatment with a delay in virus clearance. Cessation of treatment allowed activation of the antiviral immune response and viral clearance, but revived CNS pathology, demonstrating the ability of the immune response to mediate both CNS damage and virus clearance.
has issue date	2017-08-31(xsd:dateTime)
bibo:doi	10.1016/j.virol.2017.05.013
bibo:pmid	28531865
has license	els-covid
sha1sum (hex)	6ac9e5481ba73e19521cc1cb2891ec393b5f4da2
schema:url	https://doi.org/10.1016/j.virol.2017.05.013
resource representing a document's title	Glutamine antagonist-mediated immune suppression decreases pathology but delays virus clearance in mice during nonfatal alphavirus encephalomyelitis
has PubMed Central identifier	PMC5510753
has PubMed identifier	28531865
schema:publication	Virology
resource representing a document's body	covid:6ac9e5481ba73e19521cc1cb2891ec393b5f4da2#body_text
is schema:about of	named entity 'CNS' named entity 'revived' named entity 'high' named entity 'reduced' named entity 'pathology' named entity 'delays' named entity 'ABILITY' named entity 'PARTIALLY' named entity 'TREATMENT' named entity 'CESSATION' named entity 'BUT' named entity 'COMPARED' named entity 'CELL DEATH' named entity 'MEMORY IMPAIRMENT' named entity 'IMPAIRED' named entity 'DAMAGE' named entity 'REDUCED' named entity 'RESPONSE TO' named entity 'MEDIATE' named entity 'ENCEPHALOMYELITIS' named entity 'DELAY' named entity 'HIPPOCAMPAL' named entity 'DETERMINE' named entity 'DAILY' named entity 'IMMUNE RESPONSE' named entity 'HIGH' named entity 'INFECTION' named entity 'ANTIVIRAL IMMUNE RESPONSE' named entity 'PROTECTION' named entity 'GLUTAMINE ANTAGONIST' named entity 'PATHOLOGY' named entity 'INFECTED' named entity '1 WEEK' named entity 'MICE' named entity 'TREATED' named entity 'VIRAL CLEARANCE' named entity 'SINDBIS VIRUS' named entity 'MG%' named entity 'TISSUES' named entity 'EXAMINED' named entity 'ALPHAVIRUS' named entity 'VIRUS CLEARANCE' named entity 'DECREASES' named entity 'ENCEPHALOMYELITIS' named entity 'GLUTAMINE ANTAGONIST' named entity 'ALLOWED' named entity 'INTERFERON-GAMMA' named entity '2015' named entity 'CAUSES' named entity 'BASED' named entity 'LOW' named entity 'ANTIBODY' named entity 'SUPPRESSED' named entity 'MICE' named entity 'C57BL' named entity 'DOSE' named entity 'LYMPH NODE' named entity 'DON' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'UNTREATED' named entity 'STRAIN' named entity 'PRODUCTION' named entity 'MECHANISM' named entity 'CELL INFILTRATION' named entity 'CERVICAL LYMPH NODES' named entity '28S' named entity 'IMMUNE CELL' named entity 'INFLAMMATION' named entity 'LYMPHOCYTE PROLIFERATION' named entity 'RESULTING IN' named entity 'PATHOLOGY' named entity 'VIRUS CLEARANCE' named entity 'ASSOCIATED WITH' named entity '6-DIAZO-5-OXO-L-NORLEUCINE' named entity 'IMMUNE SUPPRESSION' named entity 'BUT'

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