About: Duck karyopherin α4 (duKPNA4) is involved in type I interferon expression and the antiviral response against Japanese encephalitis virus

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About: Duck karyopherin α4 (duKPNA4) is involved in type I interferon expression and the antiviral response against Japanese encephalitis virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Duck karyopherin α4 (duKPNA4) is involved in type I interferon expression and the antiviral response against Japanese encephalitis virus
Creator	Ma, Zhiyong Wang, Xin Li, Chenxi Liu, Ke Anwar, Muhammad Di, Di Li, Beibei Li, Zongjie Qiu, Yafeng Shao, Donghua Wahaab, Abdul Wei, Jianchao Xia, Qiqi
Source	Elsevier; Medline; PMC
abstract	Abstract Karyopherin α4 (KPNA4) is an adaptor molecule that mediates type I interferon (IFN) production by facilitating the nuclear translocation of IFN transcription factors. Here, we cloned the duck KPNA4 (duKPNA4) gene and analyzed its involvement in type I IFN expression as well as antiviral response against Japanese encephalitis virus (JEV). The full-length duKPNA4 gene encoded a 520-amino acid protein that shared 97.3–98.7% sequence similarity with its orthologues in chickens, humans and mice. The duKPNA4 was extensively expressed in various duck tissues at the mRNA level. Analysis of the subcellular localization of duKPNA4 by immunofluorescence assays indicated that the duKPNA4 was primarily distributed in both the cytoplasm and nucleus in primary duck embryonic fibroblasts (DEFs). However, it translocated from the cytoplasm to the nucleus in response to poly(I:C) stimulation or JEV infection. The duKPNA4 interacted with duck IFN regulatory factor 7 and facilitated its nuclear translocation, thereby up-regulating the expression of IFN-α and IFN-β in DEFs in the presence of poly(I:C) stimulation. Exogenous expression of duKPNA4 significantly elevated the expression of IFN-α and IFN-β induced by JEV infection and inhibited JEV replication in DEFs. These data demonstrate the importance of duKPNA4 in type I IFN signaling as well as the antiviral response against JEV replication.
has issue date	2020-03-31(xsd:dateTime)
bibo:doi	10.1016/j.dci.2019.103535
bibo:pmid	31697956
has license	els-covid
sha1sum (hex)	69f5f00611a1f514460d481a788de0694c9f7dd4
schema:url	https://doi.org/10.1016/j.dci.2019.103535
resource representing a document's title	Duck karyopherin α4 (duKPNA4) is involved in type I interferon expression and the antiviral response against Japanese encephalitis virus
has PubMed Central identifier	PMC7102526
has PubMed identifier	31697956
schema:publication	Developmental & Comparative Immunology
resource representing a document's body	covid:69f5f00611a1f514460d481a788de0694c9f7dd4#body_text
is schema:about of	named entity 'EXPRESSION' named entity 'JEV' named entity 'expression' named entity 'stimulation' named entity 'Interferon' named entity 'Karyopherin' named entity 'replication' named entity 'nucleus' named entity 'response' named entity 'TYPE I INTERFERON' named entity 'INTERFERON ' named entity 'KPNA4' named entity '520' named entity 'REPLICATION' named entity 'TYPE I INTERFERON' named entity 'ELEVATED' named entity 'FACILITATING' named entity 'INDICATED' named entity 'MRNA' named entity 'ADAPTOR' named entity 'TRANSCRIPTION FACTORS' named entity 'PRODUCTION' named entity 'ENCODED' named entity 'HUMANS' named entity 'DISTRIBUTED' named entity 'SIGNALING' named entity 'REGULATING' named entity 'TISSUES' named entity 'PROTEIN ' named entity 'TRANSLOCATED' named entity 'TRANSCRIPTION FACTOR 7' named entity 'LENGTH' named entity 'CLONED' named entity 'INHIBITED' named entity 'PRIMARY' named entity 'DUCK' named entity 'CHICKENS' named entity 'SEQUENCE SIMILARITY' named entity 'EXPRESSED' named entity 'MEDIATES' named entity 'NUCLEAR TRANSLOCATION' covid:arg/69f5f00611a1f514460d481a788de0694c9f7dd4 named entity 'ANTIVIRAL RESPONSE' named entity 'INTERACTED' named entity 'FIBROBLASTS' named entity 'B14' named entity 'ITS' named entity 'PRESENCE OF' named entity 'INFECTION' named entity 'GENE' named entity 'RESPONSE TO' named entity 'IFN' named entity 'EXOGENOUS' named entity 'INVOLVEMENT' named entity 'KARYOPHERIN' named entity 'DUCK' named entity 'AMINO ACID PROTEIN' named entity 'LEVEL' named entity 'NUCLEUS' named entity 'KARYOPHERIN' named entity 'INVOLVED' named entity 'CYTOPLASM' named entity 'JAPANESE ENCEPHALITIS VIRUS' named entity 'MOLECULE' named entity 'STIMULATION' named entity 'THESE' named entity 'VARIOUS' named entity 'INTERFERON ' named entity 'EXPRESSION'

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