About: Objectives, design and enrollment results from the Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure Study (INSPIRE)

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About: Objectives, design and enrollment results from the Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure Study (INSPIRE) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Objectives, design and enrollment results from the Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure Study (INSPIRE)
Creator	Gebretsadik, Tebeb Rosas-Salazar, Christian Anderson, Larry Arnold, Donald Behalf, On Chappell, James Das, Suman Dupont, William Hartert, Tina Larkin, Emma Minton, Patricia Moore, Martin Moore, Paul Polack, Fernando Stokes Peebles, R Valet, Robert
Source	Medline; PMC
abstract	BACKGROUND: Respiratory syncytial virus (RSV) lower respiratory tract infection (LRI) during infancy has been consistently associated with an increased risk of childhood asthma. In addition, evidence supports that this relationship is causal. However, the mechanisms through which RSV contributes to asthma development are not understood. The INSPIRE (Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure) study objectives are to: 1) characterize the host phenotypic response to RSV infection in infancy and the risk of recurrent wheeze and asthma, 2) identify the immune response and lung injury patterns of RSV infection that are associated with the development of early childhood wheezing illness and asthma, and 3) determine the contribution of specific RSV strains to early childhood wheezing and asthma development. This article describes the INSPIRE study, including study aims, design, recruitment results, and enrolled population characteristics. METHODS/DESIGN: The cohort is a population based longitudinal birth cohort of term healthy infants enrolled during the first months of life over a two year period. Respiratory infection surveillance was conducted from November to March of the first year of life, through surveys administered every two weeks. In-person illness visits were conducted if infants met pre-specified criteria for a respiratory illness visit. Infants will be followed annually to ages 3-4 years for assessment of the primary endpoint: wheezing illness. Nasal, urine, stool and blood samples were collected at various time points throughout the study for measurements of host and viral factors that predict wheezing illness. Nested case-control studies will additionally be used to address other primary and secondary hypotheses. DISCUSSION: In the INSPIRE study, 1952 infants (48% female) were enrolled during the two enrollment years and follow-up will continue through 2016. The mean age of enrollment was 60 days. During winter viral season, more than 14,000 surveillance surveys were carried out resulting in 2,103 respiratory illness visits on 1189 infants. First year follow-up has been completed on over 95% percent of participants from the first year of enrollment. With ongoing follow-up for wheezing and childhood asthma outcomes, the INSPIRE study will advance our understanding of the complex causal relationship between RSV infection and early childhood wheezing and asthma.
has issue date	2015-04-30(xsd:dateTime)
bibo:doi	10.1186/s12890-015-0040-0
bibo:pmid	26021723
has license	cc-by
sha1sum (hex)	69f5726e6b53f93b94630c1388479879f49f456e
schema:url	https://doi.org/10.1186/s12890-015-0040-0
resource representing a document's title	Objectives, design and enrollment results from the Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure Study (INSPIRE)
has PubMed Central identifier	PMC4506623
has PubMed identifier	26021723
schema:publication	BMC Pulm Med
resource representing a document's body	covid:69f5726e6b53f93b94630c1388479879f49f456e#body_text
is schema:about of	named entity 'INSPIRE' named entity 'asthma' named entity 'Asthma' named entity 'evidence' named entity 'Objectives' named entity 'RSV' named entity 'INSPIRE' named entity 'EXPOSURE' named entity 'MECHANISMS' named entity 'LOWER RESPIRATORY TRACT INFECTION' named entity 'EXPOSURE' named entity 'DEVELOPMENT' named entity 'RECRUITMENT' named entity 'RESPIRATORY SYNCYTIAL VIRUS' named entity 'EARLY CHILDHOOD' named entity 'ARTICLE' named entity 'SUSCEPTIBILITY' named entity 'OBJECTIVES' named entity 'AIMS' named entity 'STUDY' named entity 'DETERMINE' named entity 'RELATIONSHIP' named entity 'ASTHMA' named entity 'ILLNESS' named entity 'EVIDENCE' named entity 'RSV' named entity 'CONTRIBUTION' named entity 'BACKGROUND' named entity 'RISK OF' named entity 'RESPONSE TO' named entity 'FOLLOWING' named entity 'ASTHMA' named entity 'POPULATION CHARACTERISTICS' named entity 'WHEEZING' named entity 'SPECIFIC' named entity 'FOLLOWING' named entity 'STRAINS' named entity 'CHILDHOOD ASTHMA' named entity 'OBJECTIVES' named entity 'RSV' named entity 'SUSCEPTIBILITY' named entity 'DESIGN' named entity 'RESULTS' named entity 'STUDY' named entity 'ENROLLMENT' named entity 'PULMONARY INFECTIONS' named entity 'INCREASED RISK' named entity 'ADDITION' named entity 'RECURRENT' named entity 'RSV INFECTION' named entity 'WHEEZE' named entity 'ENROLLED POPULATION' named entity 'RESULTS' named entity 'INCLUDING' named entity 'PULMONARY INFECTIONS' named entity 'UNDERSTOOD' named entity 'INFANT' named entity 'DESIGN' named entity 'LUNG INJURY' named entity 'ASSOCIATED WITH' named entity 'HOST' named entity 'IDENTIFY' named entity 'PATTERNS' named entity 'IMMUNE RESPONSE' named entity 'risk' named entity 'However'

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