About: KDELR2 Competes with Measles Virus Envelope Proteins for Cellular Chaperones Reducing Their Chaperone-Mediated Cell Surface Transport

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About: KDELR2 Competes with Measles Virus Envelope Proteins for Cellular Chaperones Reducing Their Chaperone-Mediated Cell Surface Transport Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	KDELR2 Competes with Measles Virus Envelope Proteins for Cellular Chaperones Reducing Their Chaperone-Mediated Cell Surface Transport
Creator	Schneider-Schaulies, Jürgen Fehrholz, Markus Tiwarekar, Vishakha
Source	Medline; PMC
abstract	Recently, we found that the cytidine deaminase APOBEC3G (A3G) inhibits measles (MV) replication. Using a microarray, we identified differential regulation of several host genes upon ectopic expression of A3G. One of the up-regulated genes, the endoplasmic reticulum (ER) protein retention receptor KDELR2, reduced MV replication ~5 fold when it was over-expressed individually in Vero and CEM-SS T cells. Silencing of KDELR2 in A3G-expressing Vero cells abrogated the antiviral activity induced by A3G, confirming its role as an A3G-regulated antiviral host factor. Recognition of the KDEL (Lys-Asp-Glu-Leu) motif by KDEL receptors initiates the retrograde transport of soluble proteins that have escaped the ER and play an important role in ER quality control. Although KDELR2 over-expression reduced MV titers in cell cultures, we observed no interaction between KDELR2 and the MV hemagglutinin (H) protein. Instead, KDELR2 retained chaperones in the ER, which are required for the correct folding and transport of the MV envelope glycoproteins H and fusion protein (F) to the cell surface. Our data indicate that KDELR2 competes with MV envelope proteins for binding to calnexin and GRP78/Bip, and that this interaction limits the availability of the chaperones for MV proteins, causing the reduction of virus spread and titers.
has issue date	2019-01-04(xsd:dateTime)
bibo:doi	10.3390/v11010027
bibo:pmid	30621148
has license	cc-by
sha1sum (hex)	69718b1722e6fb921fa5c56b5135454ddbdf7457
schema:url	https://doi.org/10.3390/v11010027
resource representing a document's title	KDELR2 Competes with Measles Virus Envelope Proteins for Cellular Chaperones Reducing Their Chaperone-Mediated Cell Surface Transport
has PubMed Central identifier	PMC6356275
has PubMed identifier	30621148
schema:publication	Viruses
resource representing a document's body	covid:69718b1722e6fb921fa5c56b5135454ddbdf7457#body_text
is schema:about of	named entity 'MEDIATED' named entity 'titers' named entity 'cell' named entity 'Bip' named entity 'initiates' named entity 'calnexin' named entity 'fusion protein' named entity 'chaperones' named entity 'reduction' named entity 'Transport' named entity 'REDUCING' named entity 'KDELR2' named entity 'RECOGNITION' named entity 'REGULATED' named entity 'CELL SURFACE' named entity 'FOUND' named entity 'REDUCED' named entity 'T CELLS' named entity 'THE CELL' named entity 'INDUCED' named entity 'TRANSPORT' named entity 'ONE OF' named entity 'CORRECT' named entity 'AVAILABILITY OF' named entity 'ITS' named entity 'RETROGRADE TRANSPORT' named entity 'ASP-GLU' named entity 'GRP78' named entity 'KDELR2' named entity 'ENDOPLASMIC RETICULUM' named entity 'ANTIVIRAL ACTIVITY' named entity 'VERO CELLS' named entity 'APOBEC3G' named entity 'REDUCTION' named entity 'A3G' named entity 'PROTEIN ' named entity 'THE UP' named entity 'CEM' named entity 'VIRUS' named entity 'INTERACTION' named entity 'IMPORTANT' named entity 'GENES' named entity 'HOST FACTOR' named entity 'LIMITS' named entity 'CYTIDINE DEAMINASE' named entity 'ENVELOPE' named entity 'PLAY' named entity 'ECTOPIC EXPRESSION' named entity 'FOLD' named entity 'HEMAGGLUTININ' named entity 'MEASLES' named entity 'PROTEIN RETENTION' named entity 'QUALITY CONTROL' named entity 'HAVE' named entity 'OBSERVED' named entity 'DIFFERENTIAL' named entity 'SPREAD' named entity 'MICROARRAY' named entity 'IDENTIFIED' named entity 'TRANSPORT' named entity 'CELL SURFACE' named entity 'CHAPERONE' named entity 'MEASLES VIRUS' named entity 'THEIR' named entity 'CELLULAR' named entity 'USING' named entity 'CELL CULTURES' named entity 'CAUSING' named entity 'VERO' named entity 'GLYCOPROTEINS' named entity 'RECENTLY' named entity 'ANTIVIRAL' named entity 'DATA' named entity 'RECEPTOR' named entity 'OUR' named entity 'OVER-EXPRESSED' named entity 'CONFIRMING' named entity 'HOST' named entity 'PROTEINS'

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