About: Molecular characterization of a panel of murine monoclonal antibodies specific for the SARS-coronavirus

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About: Molecular characterization of a panel of murine monoclonal antibodies specific for the SARS-coronavirus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Molecular characterization of a panel of murine monoclonal antibodies specific for the SARS-coronavirus
Creator	Andonov, Anton Berry, Jody Andonova, Maya Plummer, Frank Drebot, Mike Johnstone, Darrell Yuan, Y Gubbins, Michael
topic	covid:69403975272536434ad77f177871ffa4c828873e#this
Source	Elsevier; Medline; PMC
abstract	Abstract The availability of monoclonal antibodies (mAbs) specific for the SARS-coronavirus (SARS-CoV) is important for the development of both diagnostic tools and treatment of infection. A molecular characterization of nine monoclonal antibodies raised in immune mice, using highly purified, inactivated SARS-CoV as the inoculating antigen, is presented in this report. These antibodies are specific for numerous viral protein targets, and six of them are able to effectively neutralize SARS-CoV in vitro, including one with a neutralizing titre of 0.075nM. A phylogenetic analysis of the heavy and light chain sequences reveals that the mAbs share considerable homology. The majority of the heavy chains belong to a single Ig germline V-gene family, while considerably more sequence variation is evident in the light chain sequences. These analyses demonstrate that neutralization ability can be correlated with specific murine VH-gene alleles. For instance, one evident trend is high sequence conservation in the VH chains of the neutralizing mAbs, particularly in CDR-1 and CDR-2. The results suggest that optimization of murine mAbs for neutralization of SARS-CoV infection will likely be possible, and will aid in the development of diagnostic tools and passive treatments for SARS-CoV infection.
has issue date	2005-01-31(xsd:dateTime)
bibo:doi	10.1016/j.molimm.2004.06.032
bibo:pmid	15488951
has license	els-covid
sha1sum (hex)	69403975272536434ad77f177871ffa4c828873e
schema:url	https://doi.org/10.1016/j.molimm.2004.06.032
resource representing a document's title	Molecular characterization of a panel of murine monoclonal antibodies specific for the SARS-coronavirus
has PubMed Central identifier	PMC7112650
has PubMed identifier	15488951
schema:publication	Molecular Immunology
resource representing a document's body	covid:69403975272536434ad77f177871ffa4c828873e#body_text
is http://vocab.deri.ie/void#inDataset of	https://covidontheweb.inria.fr:4443/about/id/http/ns.inria.fr/covid19/69403975272536434ad77f177871ffa4c828873e
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