About: High neutrophil-to-lymphocyte ratio associated with progression to critical illness in older patients with COVID-19: a multicenter retrospective study

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About: High neutrophil-to-lymphocyte ratio associated with progression to critical illness in older patients with COVID-19: a multicenter retrospective study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	High neutrophil-to-lymphocyte ratio associated with progression to critical illness in older patients with COVID-19: a multicenter retrospective study
Creator	Wang, Xiaoyan Sheng, Jifang Jia, Hongyu Hao, Shaorui Yang, Meifang Hu, Jianhua Yang, Yida Zhang, Xiaoli Zheng, Lin Zhang, Yimin Gao, Jianguo Jin, Xi Lian, Jiangshan Lu, Yingfeng Yu, Guodong Yu, Xiaopeng Cai, Huan Gu, Jueqing Jin, Ciliang Ye, Chanyuan Zhang, Shanyan
Source	Medline; PMC
abstract	This retrospective cohort study aimed to investigate the correlation of the neutrophil-to-lymphocyte ratio (NLR) with critical illness in older patients with COVID-19, and evaluate the prognostic power of the NLR at admission. We enrolled 232 patients with COVID-19, aged ≥60 y, in Zhejiang province from January 17 to March 3, 2020. Primary outcomes were evaluated until April 13. Cox regression was performed for prognostic factors. Twenty-nine (12.5%) patients progressed to critical illness. Age, shortness of breath, comorbidities including hypertension, heart disease, and chronic obstructive pulmonary disease, higher NLR, lower albumin levels, and multiple mottling and ground-glass opacity were associated with progression. In the multivariate analysis, older age (hazard ratio [HR] 1.121, confidence interval [CI] 1.070-1.174, P<0.001), heart disease (HR 2.587, CI 1.156-5.787, P=0.021), higher NLR (HR 1.136, CI 1.094-1.180, P < 0.001), and multiple mottling and ground-glass opacity (HR 4.518, CI 1.906-10.712, P<0.001) remained critical illness predictors. The NLR was independently associated with progression to critical illness; the relationship was significant and graded (HR: 1.16 per unit; 95% CI: 1.10-1.22; P for trend < 0.001). Therefore, NLR can be adopted as a prognostic tool to assist healthcare providers predict the clinical outcomes of older patients suffering from COVID-19.
has issue date	2020-07-30(xsd:dateTime)
bibo:doi	10.18632/aging.103582
bibo:pmid	32730223
has license	cc-by
sha1sum (hex)	679945edf1abffbff259312d6587f19e49e6af30
schema:url	https://doi.org/10.18632/aging.103582
resource representing a document's title	High neutrophil-to-lymphocyte ratio associated with progression to critical illness in older patients with COVID-19: a multicenter retrospective study
has PubMed Central identifier	PMC7425510
has PubMed identifier	32730223
schema:publication	Aging (Albany NY)
resource representing a document's body	covid:679945edf1abffbff259312d6587f19e49e6af30#body_text
is schema:about of	named entity 'ratio' named entity 'unit' named entity 'retrospective study' named entity 'HEALTHCARE PROVIDERS' named entity 'EVALUATE' named entity 'ground-glass opacity' named entity 'patients' named entity 'COVID-19' named entity 'retrospective cohort study' named entity 'This' named entity 'critical illness' named entity 'predict' named entity 'heart disease' named entity 'Cox regression' named entity 'graded' named entity 'shortness of breath' named entity 'hypertension' named entity 'retrospective cohort study' named entity 'critical illness' named entity 'lymphocyte' named entity 'ground-glass opacity' named entity 'COVID-19' named entity 'confidence interval' named entity 'heart disease' named entity 'neutrophil' named entity 'lymphocyte' named entity 'Zhejiang' named entity 'statistical significance' named entity 'RT-PCR' named entity 'older patients' named entity 'continuous variable' named entity 'supportive care' named entity 'confidence interval' named entity 'lopinavir' named entity 'critical illness' named entity 'NLR' named entity 'NLR' named entity 'COPD' named entity 'mechanical ventilation' named entity 'NLR' named entity 'World Health Organization' named entity 'ICUs' named entity 'severe acute respiratory syndrome coronavirus 2' named entity 'Cox proportional hazards model' named entity 'ground-glass opacity' named entity 'heart disease' named entity 'older patients' named entity 'platelet' named entity 'blood oxygen saturation' named entity 'epidemiological' named entity 'antiviral treatment' named entity 'ground-glass opacity' named entity 'COVID' named entity 'institutional review board' named entity 'blood urea nitrogen' named entity 'older patients' named entity 'high levels' named entity 'COVID-19' named entity 'risk factor' named entity 'ritonavir' named entity 'heart disease'

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