About: A Peptide-based Magnetic Chemiluminescence Enzyme Immunoassay for Serological Diagnosis of Coronavirus Disease 2019 (COVID-19)

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About: A Peptide-based Magnetic Chemiluminescence Enzyme Immunoassay for Serological Diagnosis of Coronavirus Disease 2019 (COVID-19) Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	A Peptide-based Magnetic Chemiluminescence Enzyme Immunoassay for Serological Diagnosis of Coronavirus Disease 2019 (COVID-19)
Creator	Wang, Jing Liu, Ping Lin, Yong Wei, Jie Chen, Yao-Kai Hu, Yuan Fan, Kai Wang, Kun Zhang, Xiao-Li Chen, Juan Li, Zhi-Jie Tian, Wen-Guang Cai, Xue-Fei Deng, Hai-Jun Du, Hong-Xin Hu, Jie-Li Hu, Peng Huang, Ai-Long Liao, Pu Liu, Bei-Zhong Long, Quan-Xin Ren, Ji-Hua Tang, Ni Wang, De-Qiang Wu, Gui-Cheng Xiang, Jiang-Lin Chen, A-Mei Chen, Yan-Meng Gan, Chun-Yang Gao, Qing-Zhu He, Chang-Long Huang, Lu-Yi Wang, Dao-Xin Zhou, Fa-Chun
Source	Medline; PMC
abstract	SARS-CoV-2, a novel ß-coronavirus, cause severe pneumonia and has spread throughout the globe rapidly. The disease associated with SARS-CoV-2 infection is named COVID-19. To date, real-time RT-PCR is the only test able to confirm this infection. However, the accuracy of RT-PCR depends on several factors; variations in these factors might significantly lower the sensitivity of detection. Here, we developed a peptide-based luminescent immunoassay that detected immunoglobulin G (IgG) and IgM. The assay cut-off value was determined by evaluating the sera from healthy and infected patients for pathogens other than SARS-CoV-2. To evaluate assay performance, we detected IgG and IgM in the sera from confirmed patients. The positive rate of IgG and IgM was 71.4% and 57.2%, respectively. Therefore, combining our immunoassay with real-time RT-PCR might enhance the diagnostic accuracy of COVID-19.
has issue date	2020-05-08(xsd:dateTime)
bibo:doi	10.1093/infdis/jiaa243
bibo:pmid	32382737
has license	no-cc
sha1sum (hex)	676bad1105e527b64741e1b63c48f240385a37e1
schema:url	https://doi.org/10.1093/infdis/jiaa243
resource representing a document's title	A Peptide-based Magnetic Chemiluminescence Enzyme Immunoassay for Serological Diagnosis of Coronavirus Disease 2019 (COVID-19)
has PubMed Central identifier	PMC7239108
has PubMed identifier	32382737
schema:publication	J Infect Dis
resource representing a document's body	covid:676bad1105e527b64741e1b63c48f240385a37e1#body_text
is schema:about of	named entity 'globe' named entity 'factors' named entity 'infection' named entity 'Chemiluminescence' named entity 'developed' named entity 'DIAGNOSTIC ACCURACY' named entity 'GLOBE' named entity 'THESE' named entity 'rapidly' named entity 'developed' named entity 'sera' named entity 'patients' named entity 'IgG' named entity 'assay' named entity 'IgM' named entity 'COVID-19' named entity 'peptide-based' named entity 'immunoglobulin' named entity 'luminescent' named entity 'Coronavirus Disease 2019' named entity 'IgM' named entity 'Enzyme Immunoassay' named entity 'antibodies' named entity 'Peptide-based' named entity 'COVID-19' named entity 'Chemiluminescence' named entity 'patients' named entity 'Regression analysis' named entity 'peptide' named entity 'fever' named entity 'WHO' named entity 'immunoassay' named entity 'IgM' named entity 'IgG' named entity 'RNA extraction' named entity 'genomic sequence' named entity 'IgG' named entity 'IgG' named entity 'March 12' named entity 'peptide' named entity 'IgM antibodies' named entity 'serological' named entity 'C. albicans' named entity 'chemiluminescence' named entity 'amino acid sequence' named entity 'fever' named entity 'IgG' named entity 'IgM'

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