About: Characteristics of inflammatory factors and lymphocyte subsets in patients with severe COVID‐19

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Characteristics of inflammatory factors and lymphocyte subsets in patients with severe COVID‐19
Creator	Yu, Bing Tian, Bing Yu, Ni, Ming Correspondence, Bing Fang, \| Xiang, Dan-Dan
Source	Medline; PMC
abstract	To investigate the inflammatory factors and lymphocyte subsets which play an important role in the course of severe coronavirus disease 2019 (COVID‐19). A total of 27 patients with severe COVID‐19 who were admitted to Tongji Hospital in Wuhan from 1 to 21 February 2020 were recruited to the study. The characteristics of interleukin‐1β (IL‐1β), IL‐2 receptor (IL‐2R), IL‐6, IL‐8, IL‐10, tumor necrosis factor‐α (TNF)‐α, C‐reactive protein (CRP), serum ferritin and procalcitonin (PCT), and lymphocyte subsets of these patients were retrospectively compared before and after treatment. Before treatment, there was no significant difference in most inflammatory factors (IL‐1β, IL‐2R, IL‐6, IL‐8, IL‐10, CRP, and serum ferritin) between male and female patients. Levels of IL‐2R, IL‐6, TNF‐α, and CRP decreased significantly after treatment, followed by IL‐8, IL‐10, and PCT. Serum ferritin was increased in all patients before treatment but did not decrease significantly after treatment. IL‐1β was normal in most patients before treatment. Lymphopenia was common among these patients with severe COVID‐19. Analysis of lymphocyte subsets showed that CD4+ and particularly CD8+ T lymphocytes increased significantly after treatment. However, B lymphocytes and natural killer cells showed no significant changes after treatment. A pro‐inflammatory response and decreased level of T lymphocytes were associated with severe COVID‐19.
has issue date	2020-06-09(xsd:dateTime)
bibo:doi	10.1002/jmv.26070
bibo:pmid	32470153
has license	cc-by
sha1sum (hex)	6706cc82cae7f522adfea576f69ea89314276742
schema:url	https://doi.org/10.1002/jmv.26070
resource representing a document's title	Characteristics of inflammatory factors and lymphocyte subsets in patients with severe COVID‐19
has PubMed Central identifier	PMC7283881
has PubMed identifier	32470153
schema:publication	J Med Virol
resource representing a document's body	covid:6706cc82cae7f522adfea576f69ea89314276742#body_text
is schema:about of	named entity 'CHARACTERISTICS' named entity 'inflammatory' named entity 'investigate' named entity 'Tongji Hospital' named entity 'IL-6' named entity 'Chicago' named entity 'Serum ferritin' named entity 'IL-10' named entity 'bacterial infections' named entity 'multiple organ failure' named entity 'defense mechanism' named entity 'CD8 +' named entity 'TNF-α' named entity 'clinical practice' named entity 'tocilizumab' named entity 'serum ferritin' named entity 'monocyte chemoattractant protein-1' named entity 'chromosome' named entity 'pathophysiological' named entity 'body temperature' named entity 'IL-2R' named entity 'tumor necrosis factor-α' named entity 'lymphocytes' named entity 'Tongji Medical College' named entity 'viral infections' named entity 'lymphocyte subsets' named entity 'lymphocytes' named entity 'inflammatory factors' named entity 'inflammatory factors' named entity 'Medical Ethics' named entity 'IL-10' named entity 'TNF-α' named entity 'CD8 +' named entity 'plasma' named entity 'IL-1β' named entity 'IL-1β' named entity 'serum ferritin' named entity 'ferritin' named entity 'CD16' named entity 'TNF-α' named entity 'IL-1β' named entity 'CD8 +' named entity 'lymphocytes' named entity 'CRP' named entity 'COVID' named entity 'IL-8' named entity 'TNF-α' named entity 'chemokines' named entity 'interferon γ' named entity 'viral pneumonia' named entity 'lymphocytes' named entity 'COVID' named entity 'pathogenesis' named entity 'CRP' named entity 'standard deviation' named entity 'IL-7' named entity 'significant difference' named entity 'Roche' named entity 'inflammatory factors' named entity 'informed consent' named entity 'CRP' named entity 'lymphocytes' named entity 'ICU' named entity 'IL-2 receptor' named entity 'CD8 +' named entity 'procalcitonin' named entity 'Tongji Hospital' named entity 'tumor necrosis factor-α' named entity 'IL-6' named entity 'coronavirus disease 2019' named entity 'statistically significant' named entity 'adaptive immune response' named entity 'total lymphocyte count' named entity 'lung inflammation' named entity 'inflammation'

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