About: Families and clans of cysteine peptidases

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Families and clans of cysteine peptidases
Creator	Barrett, Alan Rawlings, Neil
source	PMC
abstract	The known cysteine peptidases have been classified into 35 sequence families. We argue that these have arisen from at least five separate evolutionary origins, each of which is represented by a set of one or more modern-day families, termed a clan. Clan CA is the largest, containing the papain family, C1, and others with the Cys/His catalytic dyad. Clan CB (His/Cys dyad) contains enzymes from RNA viruses that are distantly related to chymotrypsin. The peptidases of clan CC are also from RNA viruses, but have papain-like Cys/His catalytic sites. Clans CD and CE contain only one family each, those of interleukin-1β-converting enzyme and adenovirus L3 proteinase, respectively. A few families cannot yet be assigned to clans. In view of the number of separate origins of enzymes of this type, one should be cautious in generalising about the catalytic mechanisms and other properties of cysteine peptidases as a whole. In contrast, it may be safer to generalise for enzymes within a single family or clan.
has issue date	1996-01-01(xsd:dateTime)
bibo:doi	10.1007/bf02174042
bibo:pmid	32288275
has license	no-cc
sha1sum (hex)	65e9b0ff39f495f6fa060e28e60f8d7638b0eddc
schema:url	https://doi.org/10.1007/bf02174042
resource representing a document's title	Families and clans of cysteine peptidases
has PubMed Central identifier	PMC7104565
has PubMed identifier	32288275
schema:publication	Perspect Drug Discov Des
resource representing a document's body	covid:65e9b0ff39f495f6fa060e28e60f8d7638b0eddc#body_text
is schema:about of	named entity 'adenovirus' named entity 'dyad' named entity 'His' named entity 'cysteine peptidases' named entity 'ABOUT' »more»

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