About: Neurally adjusted ventilatory assist preserves cerebral blood flow velocity in patients recovering from acute brain injury

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About: Neurally adjusted ventilatory assist preserves cerebral blood flow velocity in patients recovering from acute brain injury Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Neurally adjusted ventilatory assist preserves cerebral blood flow velocity in patients recovering from acute brain injury
Creator	Navalesi, Paolo Corte, Francesco Boniolo, · Cammarota, Gianmaria Crudo, Samuele De Vita, Nello Federico Verdina, · Grossi, Francesca Lauro, · Luca Vignazia, Gian Messina, · Perucca, Raffaella Santangelo, Erminio Sguazzoti, Ilaria Tarquini, Riccardo Vaschetto, Rosanna
Source	PMC
abstract	Neurally adjusted ventilatory assist (NAVA) has never been applied in patients recovering from acute brain injury (ABI) because neural respiratory drive could be affected by intracranial disease with detrimental effects on cerebral blood flow (CBF) velocity. Our primary aim was to assess the impact of NAVA and pressure support ventilation (PSV) on CBF velocity. In fifteen adult patients recovering from ABI and undergoing invasive assisted ventilation, PSV and NAVA were applied over 30-min-lasting trials, in the following sequence: PSV(1), NAVA, and PSV(2). While PSV was set to deliver a tidal volume ranging between 6 and 8 ml kg(−1) of predicted body weight, in NAVA the level of assistance was chosen to achieve the same inspiratory peak airway pressure as PSV. At the end of each trial, a sonographic evaluation of CBF mean velocity was bilaterally obtained on the middle cerebral artery and an arterial blood gas sample was taken for analysis. CBF mean velocity was 51.8 [41.9,75.2] cm s(−1) at baseline, 51.9 [43.4,71.0] cm s(−1) in PSV(1), 53.6 [40.7,67.7] cm s(−1) in NAVA, and 49.5 [42.1,70.8] cm s(−1) in PSV(2) (p = 0.0514) on the left and 50.2 [38.0,77.7] cm s(−1) at baseline, 47.8 [41.7,68.2] cm s(−1) in PSV(1), 53.9 [40.1,78.5] cm s(−1) in NAVA, and 55.6 [35.9,74.1] cm s(−1) in PSV(2) (p = 0.8240) on the right side. No differences were detected for pH (p = 0.0551), arterial carbon dioxide tension (p = 0.8142), and oxygenation (p = 0.0928) over the entire study duration. NAVA and PSV preserved CBF velocity in patients recovering from ABI. Trial registration: The present trial was prospectively registered at www.clinicatrials.gov (NCT03721354) on October 18th, 2018. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10877-020-00523-w) contains supplementary material, which is available to authorized users.
has issue date	2020-05-09(xsd:dateTime)
bibo:doi	10.1007/s10877-020-00523-w
bibo:pmid	32388653
has license	no-cc
sha1sum (hex)	65c006029c6138f7868c8138e05d8bd84804d856
schema:url	https://doi.org/10.1007/s10877-020-00523-w
resource representing a document's title	Neurally adjusted ventilatory assist preserves cerebral blood flow velocity in patients recovering from acute brain injury
has PubMed Central identifier	PMC7223974
has PubMed identifier	32388653
schema:publication	J Clin Monit Comput
resource representing a document's body	covid:65c006029c6138f7868c8138e05d8bd84804d856#body_text
is schema:about of	named entity 'NAVA' named entity 'respiratory drive' named entity 'baseline' named entity 'velocity' named entity 'ranging' named entity 'predicted' named entity 'bilaterally' named entity 'BODY WEIGHT' named entity 'CHOSEN' named entity 'CBF VELOCITY' named entity 'Our' named entity 'PSV' named entity 'PSV' named entity 'ABI' named entity 'CBF' named entity 'oxygenation' named entity 'aim' named entity 'level' named entity 'arterial blood gas' named entity 'tidal volume' named entity 'brain injury' named entity 'registration' named entity 'invasive' named entity 'PSV' named entity 'preserved' named entity 'NAVA' named entity 'pressure' named entity 'carbon dioxide tension' named entity 'evaluation' named entity 'velocity' named entity 'NAVA' named entity 'CBF' named entity 'PSV' named entity 'CBF' named entity 'CBF' named entity 'body weight' named entity 'PSV 2' named entity 'velocity' named entity 'NAVA' named entity 'assisted ventilation' named entity 'tidal volume' named entity 'Neurally adjusted ventilatory assist' named entity 'cerebral blood flow' named entity 'patients' named entity 'PEEP' named entity 'NAVA' named entity 'NAVA' named entity 'PSV 2' named entity 'cerebral blood flow' named entity 'Cerebral blood flow' named entity 'respiratory drive' named entity 'ventilator' named entity 'MCA' named entity 'brain injury' named entity 'standard deviation' named entity 'NAVA' named entity 'carbon dioxide tension' named entity 'NAVA' named entity 'catheter' named entity 'cerebral blood flow' named entity 'B-mode' named entity 'ventilator' named entity 'core temperature' named entity 'NAVA' named entity 'oxygen delivery' named entity 'haemodynamics'

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