About: Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication

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About: Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication
Creator	Liu, Jiangning Ma, Chunmei Qin, Chuan Xu, Yanfeng Yang, Yajun Zhang, Lianfeng
Source	Medline; PMC
abstract	Human enterovirus 71 (EV71) infection causes hand, foot and mouth disease in children under 6 years old and this infection occasionally induces severe neurological complications. No vaccines or drugs are clinical available to control EV71 epidemics. In present study, we show that treatment with lycorine reduced the viral cytopathic effect (CPE) on rhabdomyosarcoma (RD) cells by inhibiting virus replication. Analysis of this inhibitory effect of lycorine on viral proteins synthesis suggests that lycorine blocks the elongation of the viral polyprotein during translation. Lycorine treatment of mice challenged with a lethal dose of EV71 resulted in reduction of mortality, clinical scores and pathological changes in the muscles of mice, which were achieved through inhibition of viral replication. When mice were infected with a moderate dose of EV71, lycorine treatment was able to protect them from paralysis. Lycorine may be a potential drug candidate for the clinical treatment of EV71-infected patients.
has issue date	2011-10-27(xsd:dateTime)
bibo:doi	10.1186/1743-422x-8-483
bibo:pmid	22029605
has license	cc-by
sha1sum (hex)	64e2d8f1f9eccda51fa3b8398c20e040c7fbcd06
schema:url	https://doi.org/10.1186/1743-422x-8-483
resource representing a document's title	Lycorine reduces mortality of human enterovirus 71-infected mice by inhibiting virus replication
has PubMed Central identifier	PMC3212826
has PubMed identifier	22029605
schema:publication	Virol J
resource representing a document's body	covid:64e2d8f1f9eccda51fa3b8398c20e040c7fbcd06#body_text
is schema:about of	named entity 'mice' named entity 'lycorine' named entity 'mice' named entity 'inhibiting' named entity 'infected' named entity 'ABLE TO' named entity 'TO CONTROL' named entity 'CANDIDATE' named entity 'MICE' named entity 'HUMAN ENTEROVIRUS 71' named entity 'SYNTHESIS' named entity 'MAY BE A' named entity 'HAND' named entity 'CHANGES' named entity 'CYTOPATHIC EFFECT' named entity 'REDUCED' named entity 'LYCORINE' named entity 'ELONGATION' named entity 'TRANSLATION' named entity 'LYCORINE' named entity 'CLINICAL TREATMENT' named entity 'INFECTION' named entity 'INFECTED' named entity 'INHIBITING' named entity 'MORTALITY' named entity 'VIRUS REPLICATION' named entity 'HUMAN ENTEROVIRUS 71' named entity 'COMPLICATIONS' named entity 'YEARS' named entity 'INHIBITORY EFFECT' named entity 'INFECTED' named entity 'MODERATE' named entity 'VIRUS REPLICATION' named entity 'CAUSES' named entity 'PATHOLOGICAL' named entity 'DRUGS' named entity 'ANALYSIS' named entity 'PRESENT' named entity 'VIRAL' named entity 'MORTALITY' named entity 'POTENTIAL' named entity 'PARALYSIS' named entity 'DOSE' named entity 'REDUCTION' named entity 'POLYPROTEIN' named entity 'DRUG' named entity 'VACCINES' named entity 'AVAILABLE' named entity 'TREATMENT' named entity 'INHIBITION OF VIRAL REPLICATION' named entity 'OLD' named entity 'NEUROLOGICAL' named entity 'BLOCKS' named entity 'OCCASIONALLY' named entity 'CELLS' named entity 'EPIDEMICS' named entity 'LETHAL DOSE' named entity 'RHABDOMYOSARCOMA' named entity 'FOOT AND MOUTH DISEASE' named entity 'MICE' named entity 'SCORES' named entity 'INHIBITING' named entity 'MUSCLES' named entity 'PATIENTS' named entity 'VIRAL PROTEINS' named entity 'CHILDREN' named entity 'STUDY' named entity 'CLINICAL' named entity 'SEVERE' covid:arg/64e2d8f1f9eccda51fa3b8398c20e040c7fbcd06 named entity 'dose' named entity 'patients' named entity 'Lycorine' named entity 'Lycorine' named entity 'replication' named entity 'lycorine'

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