About: Expression of Immunogenic Glycoprotein S Polypeptides from Transmissible Gastroenteritis Coronavirus in Transgenic Plants

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About: Expression of Immunogenic Glycoprotein S Polypeptides from Transmissible Gastroenteritis Coronavirus in Transgenic Plants Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Expression of Immunogenic Glycoprotein S Polypeptides from Transmissible Gastroenteritis Coronavirus in Transgenic Plants
Creator	Escribano, J Borca, M Carrillo, C Go Â Mez, N Parra, ³ Salinas, ²
Source	Elsevier; Medline; PMC
abstract	Abstract The use of transgenic plants as vaccine production systems was described recently. We report on the immunological response elicited by two recombinant versions of the glycoprotein S from the swine-transmissible gastroenteritis coronavirus (TGEV) expressed in transgenic plants. Arabidoposis plants were genetically transformed with cDNAs constructs encoding either the N-terminal domain (amino acid residues 1–750) or the full-length glycoprotein S of TGEV, responsible for the neutralizing antibody induction against the virus, under the control of the cauliflower mosaic virus 35S (CaMV 35S) promoter. Genomic DNA and mRNA analyses of leaf extracts from transformed plants demonstrated the incorporation of the foreign cDNA into the arabidopsis genome, as well as their transcription. Expression of recombinant polypeptides were observed in most transgenic plants by ELISA using specific antibodies. Mice immunized with leaf extracts from transgenic plants developed antibodies that reacted specifically with TGEV in ELISA, immunoprecipitated the virus-induced protein, and neutralized the virus infectivity. From these results, we conclude that transgenic plants expressing glycoprotein S polypeptides may possibly be used as a source of recombinant antigen for vaccine production.
has issue date	1998-09-30(xsd:dateTime)
bibo:doi	10.1006/viro.1998.9315
bibo:pmid	9791026
has license	els-covid
sha1sum (hex)	646825ece8ed3e5260449ed19109e1b79e3ac7cf
schema:url	https://doi.org/10.1006/viro.1998.9315
resource representing a document's title	Expression of Immunogenic Glycoprotein S Polypeptides from Transmissible Gastroenteritis Coronavirus in Transgenic Plants
has PubMed Central identifier	PMC7130976
has PubMed identifier	9791026
schema:publication	Virology
resource representing a document's body	covid:646825ece8ed3e5260449ed19109e1b79e3ac7cf#body_text
is schema:about of	named entity 'vaccine' named entity 'recombinant' named entity 'transgenic plants' named entity 'polypeptides' named entity 'DEMONSTRATED' named entity 'EITHER' named entity 'USING' named entity 'SYSTEMS' named entity 'VERSIONS' covid:arg/646825ece8ed3e5260449ed19109e1b79e3ac7cf named entity 'POSSIBLY' named entity 'THEIR' named entity 'POLYPEPTIDES' named entity 'RECENTLY' named entity 'THESE' named entity 'LENGTH' named entity 'ACID' named entity 'GENOME' named entity 'ELICITED BY' named entity 'USE OF' named entity 'RESULTS' named entity 'VACCINE PRODUCTION' named entity 'TRANSFORMED' named entity 'RECOMBINANT' named entity 'IMMUNIZED' named entity 'GLYCOPROTEIN' named entity 'IMMUNOGENIC' named entity 'EXPRESSION' named entity 'POLYPEPTIDES' named entity 'TRANSGENIC PLANTS' named entity 'CONTROL' named entity 'DESCRIBED' named entity 'TRANSCRIPTION' named entity 'USED' named entity 'SWINE' named entity 'VIRUS INFECTIVITY' named entity 'NEUTRALIZING ANTIBODY' named entity 'OBSERVED' named entity 'FOREIGN' named entity 'ANTIBODIES' named entity 'EXPRESSION' named entity 'PLANTS' named entity 'GLYCOPROTEIN' named entity 'PROMOTER' named entity 'CAULIFLOWER MOSAIC VIRUS' named entity 'TRANSMISSIBLE GASTROENTERITIS CORONAVIRUS' named entity 'SOURCE' named entity 'ENCODING' named entity 'CONCLUDE' named entity 'EXTRACTS' named entity 'INDUCED' named entity 'N-TERMINAL ' named entity 'ELISA' named entity '35S' named entity 'RESPONSIBLE' named entity 'PROTEIN' named entity 'CDNA' named entity 'VIRUS' named entity 'IMMUNOLOGICAL RESPONSE' named entity 'B1750' named entity 'ARABIDOPSIS' named entity 'GENOMIC DNA' named entity 'EXPRESSED' named entity 'RECOMBINANT ANTIGEN' named entity 'TRANSGENIC PLANTS' named entity 'DOMAIN' named entity 'LEAF' named entity 'MRNA' named entity 'MICE' named entity 'SPECIFIC' named entity 'INDUCTION' named entity 'TRANSMISSIBLE GASTROENTERITIS CORONAVIRUS' named entity 'REPORT' named entity 'encoding' named entity 'glycoprotein' named entity 'reacted'

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