About: Hepatitis B Virus Genotype G forms core-like particles with unique structural properties

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Hepatitis B Virus Genotype G forms core-like particles with unique structural properties
Creator	Lawrence, C Osiowy, C Teow, S Beniac, D Booth, T Cotelesage, J Devarennes, S
Source	PMC
abstract	SUMMARY: We have determined the structure of the core capsid of an unusual variant of hepatitis B virus, genotype G (HBV/G) at 14 Å resolution, using cryo-electron microscopy. The structure reveals surface features not present in the prototype HBV/A genotype. HBV/G is novel in that it has a unique 36- bp insertion downstream of the core gene start codon. This results in a twelve amino acid insertion at the N-terminal end of the core protein, and two stop codons in the precore region that prevent the expression of HBeAg. HBV/G replication in patients is associated with co-infection with another genotype of HBV, suggesting that HBV/G may have reduced replication efficiency in vivo. We localized the N-terminal insertion in HBV/G and show that it forms two additional masses on the core surface adjacent to each of the dimer-spikes and have modelled the structure of the additional residues within this density. We show that the position of the insertion would not interfere with translocation of nucleic acids through the pores to the core interior compartment. However, the insertion may partially obscure several residues on the core surface that are known to play a role in envelopment and secretion of virions, or that could affect structural rearrangements that may trigger envelopment after DNA second-strand synthesis.
has issue date	2011-06-01(xsd:dateTime)
bibo:doi	10.1111/j.1365-2893.2010.01330.x
bibo:pmid	20546498
has license	cc-by
sha1sum (hex)	621648da481a06d1a2bb80c56e998f7373215be6
schema:url	https://doi.org/10.1111/j.1365-2893.2010.01330.x
resource representing a document's title	Hepatitis B Virus Genotype G forms core-like particles with unique structural properties
has PubMed Central identifier	PMC3116152
has PubMed identifier	20546498
schema:publication	J Viral Hepat
resource representing a document's body	covid:621648da481a06d1a2bb80c56e998f7373215be6#body_text
is schema:about of	named entity 'HEPATITIS B VIRUS GENOTYPE G' named entity 'PARTICLES' named entity 'This' named entity 'secretion' named entity 'localized' named entity 'insertion' named entity 'protein' named entity 'structure' named entity 'TRANSLOCATION' named entity 'EXPRESSION' named entity 'AMINO ACID INSERTION' named entity 'SECOND-STRAND' named entity 'FEATURES' named entity 'AFFECT' named entity 'SPIKES' named entity 'REDUCED' named entity 'PRECORE REGION' named entity 'PLAY' named entity 'KNOWN' named entity 'NOT PRESENT' named entity 'DIMER' named entity 'REPLICATION' named entity 'PARTIALLY' named entity 'STRUCTURAL' named entity 'N-TERMINAL ' named entity 'ADJACENT TO' named entity 'DOWNSTREAM' named entity 'IN VIVO' named entity 'CORE' named entity 'INTERFERE' named entity 'RESULTS' named entity 'MODELLED' named entity 'NOVEL' named entity 'GENE' named entity 'ADDITIONAL' named entity 'INSERTION' named entity 'VARIANT' named entity 'CO-INFECTION' named entity 'STRUCTURAL' named entity 'UNIQUE' named entity 'SECRETION' named entity 'START CODON' named entity 'COMPARTMENT' named entity 'END' named entity 'DNA' named entity 'ROLE' named entity 'SYNTHESIS' named entity 'FORMS' named entity 'ASSOCIATED WITH' named entity 'HBV' covid:arg/621648da481a06d1a2bb80c56e998f7373215be6 named entity 'USING' named entity 'CORE PROTEIN' named entity 'MAY HAVE' named entity 'HEPATITIS B VIRUS' named entity 'FORMS' named entity 'LIKE' named entity 'CORE' named entity 'CAPSID' named entity 'UNUSUAL' named entity 'NUCLEIC ACIDS' named entity 'PREVENT' named entity 'REVEALS' named entity 'RESOLUTION' named entity 'CRYO-ELECTRON MICROSCOPY' named entity 'LOCALIZED' named entity 'REARRANGEMENTS' named entity 'STOP CODONS' named entity 'EFFICIENCY' named entity 'POSITION' named entity 'STRUCTURE' named entity 'TRIGGER' named entity 'HAVE' named entity 'OBSCURE' named entity 'PATIENTS'

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