About: Not just angiotensinases: new roles for the angiotensin-converting enzymes

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Not just angiotensinases: new roles for the angiotensin-converting enzymes
Creator	Ae, Daniel Ae, Nicola Turner, Anthony
Source	Medline; PMC
abstract	The renin-angiotensin system (RAS) is a critical regulator of blood pressure and fluid homeostasis. Angiotensin II, the primary bioactive peptide of the RAS, is generated from angiotensin I by angiotensin-converting enzyme (ACE). A homologue of ACE, ACE2, is able to convert angiotensin II to a peptide with opposing effects, angiotensin-(1-7). It is proposed that disturbance of the balance of ACE and ACE2 expression and/or function is important in pathologies in which angiotensin II plays a role. These include cardiovascular and renal disease, lung injury and liver fibrosis. The critical roles of ACE and ACE2 in regulating angiotensin II levels have traditionally focussed attention on their activities as angiotensinases. Recent discoveries, however, have illuminated the roles of these enzymes and of the ACE2 homologue, collectrin, in intracellular trafficking and signalling. This paper reviews the key literature regarding both the catalytic and non-catalytic roles of the angiotensin-converting enzyme gene family.
has issue date	2009-09-10(xsd:dateTime)
bibo:doi	10.1007/s00018-009-0152-x
bibo:pmid	19763395
has license	no-cc
sha1sum (hex)	61e3a9e97cc0cd4e09add2a6cc45861a57283fcd
schema:url	https://doi.org/10.1007/s00018-009-0152-x
resource representing a document's title	Not just angiotensinases: new roles for the angiotensin-converting enzymes
has PubMed Central identifier	PMC7079792
has PubMed identifier	19763395
schema:publication	Cell Mol Life Sci
resource representing a document's body	covid:61e3a9e97cc0cd4e09add2a6cc45861a57283fcd#body_text
is schema:about of	named entity 'NEW' named entity 'function' named entity 'renin-angiotensin system' named entity 'literature' named entity 'homeostasis' named entity 'LUNG INJURY' named entity 'ACE2' named entity 'INCLUDE' named entity 'REGULATING' named entity 'THESE' named entity 'IS A' named entity 'RENAL DISEASE' named entity 'LIVER FIBROSIS' named entity 'BLOOD PRESSURE' named entity 'GENERATED' named entity 'ENZYMES' named entity 'TRAFFICKING' named entity 'ROLE' named entity 'IMPORTANT' named entity 'PRIMARY' named entity 'ROLES' named entity 'SIGNALLING' named entity 'ANGIOTENSIN I' named entity 'RENIN-ANGIOTENSIN SYSTEM' named entity 'BIOACTIVE PEPTIDE' named entity 'ROLES' named entity 'PAPER' named entity 'CARDIOVASCULAR' named entity 'ENZYMES' named entity 'ANGIOTENSIN' named entity 'CONVERTING' named entity 'RECENT' named entity 'ENZYME GENE' named entity 'LITERATURE' named entity 'FLUID' named entity 'PATHOLOGIES' named entity 'JUST' named entity 'DISTURBANCE' named entity 'PEPTIDE' named entity 'PROPOSED' named entity 'ANGIOTENSIN' named entity 'EFFECTS' named entity 'THEIR' named entity 'FUNCTION' named entity 'HOMOLOGUE' named entity 'TO CONVERT' named entity 'BALANCE' named entity 'REVIEWS' named entity 'HOMEOSTASIS' named entity 'RAS' named entity 'HAVE' named entity 'KEY' named entity 'ILLUMINATED' named entity 'CRITICAL' named entity 'ACE' named entity 'ACTIVITIES' named entity 'LEVELS' named entity 'CATALYTIC' named entity 'EXPRESSION' named entity 'ANGIOTENSIN II' named entity 'COLLECTRIN' named entity 'INTRACELLULAR' named entity 'ATTENTION' named entity 'GENE FAMILY' named entity 'ANGIOTENSIN-CONVERTING ENZYME' named entity 'PLAYS' named entity 'REGULATOR' covid:arg/61e3a9e97cc0cd4e09add2a6cc45861a57283fcd named entity 'fluid' named entity 'ACE' named entity 'peptide' named entity 'catalytic' named entity 'ACE2' named entity 'angiotensin II' named entity 'homologue' named entity 'bioactive' named entity 'liver fibrosis' named entity 'blood pressure' named entity 'ACE'

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