About: PI3K/Akt/p53 pathway inhibits reovirus infection

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	PI3K/Akt/p53 pathway inhibits reovirus infection
Creator	Qu, Liandong Tian, Jin Liu, Chunguo Wu, Hongxia Zhang, Xiaozhan
Source	Elsevier; Medline; PMC
abstract	Viral infections activate many host signaling pathways, including the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, which has recently attracted considerable interest due to its central role in modulating virus replication. This study demonstrated that the sero-type 3 reovirus strain Masked Palm Civet/China/2004 (MPC/04) could transiently activate the PI3K/Akt pathway in A549 cells at earlier time points of infection. The blockage of PI3K/Akt activation increased viral RNA synthesis and yield. The role of the downstream effectors MDM2/p53 of PI3K/Akt in regulating reovirus replication was further analyzed. We found that during reovirus infection, the level of phosphorylated MDM2 (p-MDM2) was increased and the expression of p53 was reduced. In addition, the blockage of PI3K/Akt by Ly294002 or knockdown of Akt by siRNA reduced the level of p-MDM2 and increased the level of p53. Both indicated that the downstream effectors MDM2/p53 of PI3K/Akt were activated. Pre-treatment with Nutlin, which can destroy MDM2 and p53 cross-talk and increase the expression of p53 RNA and protein, dose-dependently enhanced reovirus replication. Additionally, the overexpression of p53 alone also supported reovirus replication, and knockdown of p53 significantly inhibited viral replication. This study demonstrates that PI3K/Akt/p53 activated by mammalian reovirus can serve as a pathway for inhibiting virus replication/infection, yet the precise mechanism of this process remains under further investigation.
has issue date	2015-06-09(xsd:dateTime)
bibo:doi	10.1016/j.meegid.2015.06.008
bibo:pmid	26066464
has license	no-cc
sha1sum (hex)	6095a04fde33482975d02a46069943568b11ebe7
schema:url	https://doi.org/10.1016/j.meegid.2015.06.008
resource representing a document's title	PI3K/Akt/p53 pathway inhibits reovirus infection
has PubMed Central identifier	PMC7106092
has PubMed identifier	26066464
schema:publication	Infect Genet Evol
resource representing a document's body	covid:6095a04fde33482975d02a46069943568b11ebe7#body_text
is schema:about of	named entity 'This' named entity 'viral' named entity 'remains' named entity 'viral replication' named entity 'p53' named entity 'phosphatidylinositol 3-kinase' named entity 'reovirus' named entity 'activated' named entity 'Akt' named entity 'PI3K' named entity 'REMAINS' named entity 'MASKED PALM CIVET' named entity 'AKT' named entity 'DESTROY' named entity 'DEMONSTRATED' named entity 'HOST' named entity 'TYPE 3' named entity 'A549 CELLS' named entity 'INCREASED' named entity 'REDUCED' named entity 'OVEREXPRESSION' named entity 'MDM2' named entity 'ANALYZED' named entity 'TIME' named entity 'VIRAL REPLICATION' named entity 'ROLE' named entity 'REGULATING' named entity 'POINTS' named entity 'PI3K' named entity 'RNA SYNTHESIS' named entity 'NUTLIN' named entity 'CROSS-TALK' named entity 'PHOSPHORYLATED' named entity '28P' named entity 'ITS' named entity 'DOWNSTREAM' named entity 'P53' named entity 'FOUND' named entity 'ADDITION' named entity 'S T' named entity 'STRAIN' named entity 'VIRAL RNA' named entity 'PRECISE' named entity 'PRE' named entity 'STUDY' named entity 'LEVEL' named entity 'TREATMENT' named entity 'ACTIVATE' named entity 'LY294002' named entity 'RNA' named entity 'INFECTION' named entity 'BLOCKAGE' named entity 'INDICATED' named entity 'INTEREST' named entity 'INCLUDING' named entity 'ACTIVATION' named entity 'PATHWAY' named entity 'VIRUS REPLICATION' named entity 'SIRNA' named entity 'MAMMALIAN REOVIRUS' named entity 'PI3K' named entity 'MODULATING' named entity 'YIELD' named entity 'ENHANCED' named entity 'MECHANISM' named entity 'EXPRESSION' named entity 'ACTIVATED' named entity 'INVESTIGATION' named entity 'CONSIDERABLE' named entity 'PROCESS' named entity 'DOSE' named entity 'INHIBITED' named entity 'PATHWAY' named entity 'PROTEIN' named entity 'EARLIER' named entity 'REOVIRUS' named entity 'SUPPORTED'

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