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About:
Neutralizing Antibodies Responses to SARS-CoV-2 in COVID-19 Inpatients and Convalescent Patients
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covidontheweb.inria.fr
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Academic Article
research paper
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type
Academic Article
research paper
schema:ScholarlyArticle
isDefinedBy
Covid-on-the-Web dataset
title
Neutralizing Antibodies Responses to SARS-CoV-2 in COVID-19 Inpatients and Convalescent Patients
Creator
Chu, Yanhui
Wang, Quanyi
Li, Jing
Wang, Xiaoli
Pan, Yang
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source
MedRxiv
abstract
Background. COVID-19 is a pandemic with no specific antiviral treatments or vaccines. The urgent needs for exploring the neutralizing antibodies from patients with different clinical characteristics are emerging. Methods. A total of 117 blood samples were collected from 70 COVID-19 inpatients and convalescent patients. The presence of neutralizing antibody was determined with a modified cytopathogenic assay based on live SARS-CoV-2. The dynamics of neutralizing antibody levels at different with different clinical characteristics were analyzed. Results. The seropositivity rate reached up to 100.0% within 20 days since onset, and remained 100.0% till day 41-53. The total GMT was 1:163.7 (95% CI, 128.5 to 208.6), and the antibody level was highest during day 31-40 since onset, and then decreased slightly. Individual differences in changes of antibody levels were observed among 8 representative convalescent patients. In multivariate GEE analysis, patients at age of 31-60 and 61-84 had a higher antibody level than those at age of 16-30 (β=1.0518, P=0.0152; β=1.3718, P=0.0020). Patients with a worse clinical classification had a higher antibody titer (β=0.4639, P=0.0227). Conclusions. The neutralizing antibodies were detected even at the early stage of disease, and a significant response showed in convalescent patients. Moreover, changes on antibody levels ware individual specific.
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2020-04-18
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bibo:doi
10.1101/2020.04.15.20065623
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medrxiv
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5f9db5381c15cb1cd77d11eef019e14829da5b92
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https://doi.org/10.1101/2020.04.15.20065623
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Neutralizing Antibodies Responses to SARS-CoV-2 in COVID-19 Inpatients and Convalescent Patients
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covid:5f9db5381c15cb1cd77d11eef019e14829da5b92#body_text
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named entity 'neutralizing antibodies'
named entity 'SARS-CoV-2'
named entity 'Neutralizing Antibodies'
named entity 'Hubei'
named entity 'peer review'
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