About: Transcriptome Analysis Reveals Dynamic Gene Expression Profiles in Porcine Alveolar Macrophages in Response to the Chinese Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus

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About: Transcriptome Analysis Reveals Dynamic Gene Expression Profiles in Porcine Alveolar Macrophages in Response to the Chinese Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Transcriptome Analysis Reveals Dynamic Gene Expression Profiles in Porcine Alveolar Macrophages in Response to the Chinese Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus
Creator	Zhou, Lei Ge, Xinna Guo, Xin Yang, Hanchun Wang, Cong Han, Jun Liu, Siyu Miao, Qi Zeng, Nanfang
Source	Medline; PMC
abstract	Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important swine pathogens and causes reproductive failure in sows and respiratory disease in growing pigs. PRRSV mainly infects porcine alveolar macrophages (PAMs), leading to the subversion of innate and adaptive immunity of pigs. The transcriptome analysis of gene expression profiles in PRRSV-infected PAMs is essential for understanding the pathogenesis of PRRSV. Here we performed next-generation RNA sequencing and a comprehensive bioinformatics analysis to characterize the dynamic transcriptome landscapes in PAMs following PRRSV infection. Totally 38222 annotated mRNAs, 12987 annotated long noncoding RNAs (lncRNAs), and 17624 novel lncRNAs in PRRSV-infected PAMs were identified through a transcripts computational identification pipeline. The differentially expressed mRNAs and lncRNAs during PRRSV infection were characterized. Several differentially expressed transcripts were validated using qRT-PCR. Analyses on dynamic overrepresented GO terms and KEGG pathways in PRRSV-infected PAMs at different time points were performed. Meanwhile the genes involved in IFN-related signaling pathways, proinflammatory cytokines and chemokines, phagocytosis, and antigen presentation and processing were significantly downregulated, indicating the aberrant function of PAMs during PRRSV infection. Moreover, the differentially and highly expressed lncRNA XR_297549.1 was predicted to both cis-regulate and trans-regulate its neighboring gene, prostaglandin-endoperoxide synthase 2 (PTGS2), indicating its role in inflammatory response. Our findings reveal the transcriptome profiles and differentially expressed mRNAs and lncRNAs in PRRSV-infected PAMs in vitro, providing valuable information for further exploration of PRRSV pathogenesis.
has issue date	2018-04-29(xsd:dateTime)
bibo:doi	10.1155/2018/1538127
bibo:pmid	29854728
has license	cc-by
sha1sum (hex)	5f938778c47463eaa1e15fd63c0656cf830220e3
schema:url	https://doi.org/10.1155/2018/1538127
resource representing a document's title	Transcriptome Analysis Reveals Dynamic Gene Expression Profiles in Porcine Alveolar Macrophages in Response to the Chinese Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus
has PubMed Central identifier	PMC5949201
has PubMed identifier	29854728
schema:publication	Biomed Res Int
resource representing a document's body	covid:5f938778c47463eaa1e15fd63c0656cf830220e3#body_text
is schema:about of	named entity 'GENE EXPRESSION PROFILES' named entity 'DYNAMIC' named entity 'USING' named entity 'EXPLORATION' named entity 'TIME' named entity 'UNDERSTANDING' named entity 'OUR' named entity 'TRANSCRIPTOME ANALYSIS' named entity 'PAMS' named entity 'IDENTIFIED' named entity 'NOVEL' named entity 'PORCINE' named entity 'PHAGOCYTOSIS' named entity 'HIGHLY' named entity 'INDICATING' named entity 'GENE EXPRESSION PROFILES' named entity 'CHEMOKINES' named entity 'IDENTIFICATION' named entity 'INVOLVED' named entity 'ITS' named entity 'LONG' named entity 'SOWS' named entity 'TRANSCRIPTOME ANALYSIS' named entity 'GENES' named entity 'ECONOMICALLY IMPORTANT' named entity 'FOLLOWING' named entity 'IN VITRO' named entity 'ANNOTATED' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'ABERRANT' named entity '17624' named entity 'IFN' named entity 'PATHOGENESIS' named entity 'INFLAMMATORY RESPONSE' named entity 'HIGHLY' named entity 'PROCESSING' named entity 'TOTALLY' named entity 'RESPIRATORY DISEASE' named entity 'TRANSCRIPTOME' named entity 'SWINE' named entity 'REVEALS' named entity 'PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS' named entity 'PORCINE' named entity 'CHINESE' named entity 'PATHOGENIC' named entity 'DYNAMIC' named entity 'ALVEOLAR MACROPHAGES' named entity 'COMPREHENSIVE' named entity 'FUNCTION' named entity 'REPRODUCTIVE FAILURE' named entity 'RNAS' named entity 'GENERATION' named entity 'PROINFLAMMATORY CYTOKINES' named entity 'NEIGHBORING' named entity 'KEGG' named entity '12987' named entity 'BIOINFORMATICS ANALYSIS' named entity 'SIGNALING PATHWAYS' named entity 'REVEAL' named entity 'PIPELINE' named entity 'ANTIGEN PRESENTATION' named entity 'PATHOGENS' named entity 'COMPUTATIONAL' named entity 'CHARACTERIZED' named entity 'RELATED' named entity 'HERE' named entity 'ALVEOLAR MACROPHAGES' named entity 'TRANSCRIPTS' named entity 'ADAPTIVE IMMUNITY' named entity 'TERMS' named entity 'TO CHARACTERIZE' named entity 'PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE 2' named entity 'LEADING'

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