About: Targeted Strategies for Henipavirus Therapeutics

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Targeted Strategies for Henipavirus Therapeutics
Creator	Bingham, John Middleton, Deborah Bossart, Katharine
Source	Medline; PMC
abstract	Hendra and Nipah viruses are related emergent paramyxoviruses that infect and cause disease in animals and humans. Disease manifests as a generalized vasculitis affecting multiple organs, but is the most severe in the respiratory and central nervous systems. The high case fatality and person-to-person transmission associated with the most recent NiV outbreaks, and the recent re-emergence of HeV, emphasize the importance and necessity of effective therapeutics for these novel agents. In recent years henipavirus research has revealed a more complete understanding of pathogenesis and, as a consequence, viable approaches towards vaccines and therapeutics have emerged. All strategies target early steps in viral replication including receptor binding and membrane fusion. Animal models have been developed, some of which may prove more valuable than others for evaluating the efficacy of therapeutic agents and regimes. Assessments of protective host immunity and drug pharmacokinetics will be crucial to the further advancement of therapeutic compounds.
has issue date	2007-09-28(xsd:dateTime)
bibo:doi	10.2174/1874357900701010014
bibo:pmid	19440455
has license	cc-by
sha1sum (hex)	5f8d96a8606eb6c9a89a1160f8b498c6c0efecba
schema:url	https://doi.org/10.2174/1874357900701010014
resource representing a document's title	Targeted Strategies for Henipavirus Therapeutics
has PubMed Central identifier	PMC2675550
has PubMed identifier	19440455
schema:publication	Open Virol J
resource representing a document's body	covid:5f8d96a8606eb6c9a89a1160f8b498c6c0efecba#body_text
is schema:about of	named entity 'Nipah' named entity 'Therapeutics' named entity 'NECESSITY' named entity 'EFFECTIVE' named entity 'GENERALIZED' named entity 'HENIPAVIRUS' named entity 'MEMBRANE FUSION' named entity 'INCLUDING' named entity 'TARGET' named entity 'NIV' named entity 'HEV' named entity 'ANIMALS' named entity 'EMERGENCE' named entity 'CAUSE DISEASE' named entity 'THESE' named entity 'HIGH' named entity 'HENIPAVIRUS' named entity 'STRATEGIES' named entity 'HOST IMMUNITY' named entity 'EFFICACY' named entity 'COMPLETE' named entity 'MANIFESTS' named entity 'CONSEQUENCE' named entity 'ANIMAL MODELS ' named entity 'DISEASE' named entity 'TARGETED' named entity 'THERAPEUTICS' named entity 'EMERGENT' named entity 'SEVERE' named entity 'ADVANCEMENT' named entity 'VIRAL REPLICATION' named entity 'RELATED' named entity 'BUT' named entity 'RESPIRATORY' named entity 'PARAMYXOVIRUSES' named entity 'EVALUATING' named entity 'INFECT' named entity 'VIABLE' named entity 'THERAPEUTIC' named entity 'EARLY' named entity 'NIPAH VIRUSES' named entity 'STRATEGIES' named entity 'PHARMACOKINETICS' named entity 'UNDERSTANDING' named entity 'HUMANS' named entity 'ORGANS' named entity 'RECENT' named entity 'HAVE' named entity 'MULTIPLE' named entity 'STEPS' named entity 'NOVEL' named entity 'OUTBREAKS' named entity 'PATHOGENESIS' named entity 'VACCINES' named entity 'ASSOCIATED WITH' named entity 'YEARS' named entity 'THERAPEUTIC AGENTS' named entity 'APPROACHES' named entity 'CENTRAL NERVOUS SYSTEMS' named entity 'MOST RECENT' named entity 'VASCULITIS' named entity 'THERAPEUTICS' named entity 'DRUG' named entity 'RECEPTOR BINDING' named entity 'RESEARCH' named entity 'ASSESSMENTS' named entity 'CASE' named entity 'AFFECTING' named entity 'REVEALED' named entity 'efficacy' named entity 'immunity' named entity 'vascular disease' named entity 'animal species' named entity 'paramyxoviruses' named entity 'glycoprotein' named entity 'endothelial cells' named entity 'sialic acid' named entity 'vaccine' named entity 'glycoproteins'

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