About: Bactericidal assessment of nano-silver on emerging and re-emerging human pathogens

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Bactericidal assessment of nano-silver on emerging and re-emerging human pathogens
Creator	Anuj, Samir Gajera, Harsukh Golakiya, Baljibhai Hirpara, Darshna
Source	Elsevier; Medline; PMC
abstract	Abstract With the threat of the growing number of bacteria resistant to antibiotics, the re-emergence of previously deadly infections and the emergence of new infections, there is an urgent need for novel therapeutic agent. Silver in the nano form, which is being used increasingly as antibacterial agents, may extend its antibacterial application to emerging and re-emerging multidrug-resistant pathogens, the main cause of nosocomial diseases worldwide. In the present study, a completely bottom up method to prepare green nano-silver was used. To explore the action of nano-silver on emerging Bacillus megaterium MTCC 7192 and re-emerging Pseudomonas aeruginosa MTCC 741 pathogenic bacteria, the study includes an analysis of the bacterial membrane damage through Scanning Electron Microscope (SEM) as well as alternation of zeta potential and intracellular leakages. In this work, we observed genuine bactericidal property of nano-silver as compare to broad spectrum antibiotics against emerging and re-emerging mode. After being exposed to nano-silver, the membrane becomes scattered from their original ordered arrangement based on SEM observation. Moreover, our results also suggested that alternation of zeta potential enhanced membrane permeability, and beyond a critical point, it leads to cell death. The leakages of intracellular constituents were confirmed by Gas Chromatography-Mass Spectrometry (GC–MS). In conclusion, the combine results suggested that at a specific dose, nano-silver may destroy the structure of bacterial membrane and depress its activity, which causes bacteria to die eventually.
has issue date	2019-01-31(xsd:dateTime)
bibo:doi	10.1016/j.jtemb.2018.04.028
bibo:pmid	29735327
has license	els-covid
sha1sum (hex)	5f76d6cb9e9d31374a2e34196acddd84f88aa04c
schema:url	https://doi.org/10.1016/j.jtemb.2018.04.028
resource representing a document's title	Bactericidal assessment of nano-silver on emerging and re-emerging human pathogens
has PubMed Central identifier	PMC7126441
has PubMed identifier	29735327
schema:publication	Journal of Trace Elements in Medicine and Biology
resource representing a document's body	covid:5f76d6cb9e9d31374a2e34196acddd84f88aa04c#body_text
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