About: Human Sentinel Surveillance of Influenza and Other Respiratory Viral Pathogens in Border Areas of Western Cambodia

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About: Human Sentinel Surveillance of Influenza and Other Respiratory Viral Pathogens in Border Areas of Western Cambodia Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Human Sentinel Surveillance of Influenza and Other Respiratory Viral Pathogens in Border Areas of Western Cambodia
Creator	Chuang, I Melendrez, M Open Access Citation ; Timmermans, A Samon, N Se, Y Uthaimongkol, N
Source	Medline; PMC
abstract	Little is known about circulation of influenza and other respiratory viruses in remote populations along the Thai-Cambodia border in western Cambodia. We screened 586 outpatients (median age 5, range 1–77) presenting with influenza-like-illness (ILI) at 4 sentinel sites in western Cambodia between May 2010 and December 2012. Real-time reverse transcriptase (rRT) PCR for influenza was performed on combined nasal and throat specimens followed by viral culture, antigenic analysis, antiviral susceptibility testing and full genome sequencing for phylogenetic analysis. ILI-specimens negative for influenza were cultured, followed by rRT-PCR for enterovirus and rhinovirus (EV/RV) and EV71. Influenza was found in 168 cases (29%) and occurred almost exclusively in the rainy season from June to November. Isolated influenza strains had close antigenic and phylogenetic relationships, matching vaccine and circulating strains found elsewhere in Cambodia. Influenza vaccination coverage was low (<20%). Western Cambodian H1N1(2009) isolate genomes were more closely related to 10 earlier Cambodia isolates (94.4% genome conservation) than to 13 Thai isolates (75.9% genome conservation), despite sharing the majority of the amino acid changes with the Thai references. Most genes showed signatures of purifying selection. Viral culture detected only adenovirus (5.7%) and parainfluenza virus (3.8%), while non-polio enteroviruses (10.3%) were detected among 164 culture-negative samples including coxsackievirus A4, A6, A8, A9, A12, B3, B4 and echovirus E6 and E9 using nested RT-PCR methods. A single specimen of EV71 was found. Despite proximity to Thailand, influenza epidemiology of these western Cambodian isolates followed patterns observed elsewhere in Cambodia, continuing to support current vaccine and treatment recommendations from the Cambodian National Influenza Center. Amino acid mutations at non-epitope sites, particularly hemagglutinin genes, require further investigation in light of an increasingly important role of permissive mutations in influenza virus evolution. Further research about the burden of adenovirus and non-polio enteroviruses as etiologic agents in acute respiratory infections in Cambodia is also needed.
has issue date	2016-03-30(xsd:dateTime)
bibo:doi	10.1371/journal.pone.0152529
bibo:pmid	27028323
has license	cc0
sha1sum (hex)	5f3f613be264f8b10318dfe8e92777fe7a95848e
schema:url	https://doi.org/10.1371/journal.pone.0152529
resource representing a document's title	Human Sentinel Surveillance of Influenza and Other Respiratory Viral Pathogens in Border Areas of Western Cambodia
has PubMed Central identifier	PMC4814059
has PubMed identifier	27028323
schema:publication	PLoS One
resource representing a document's body	covid:5f3f613be264f8b10318dfe8e92777fe7a95848e#body_text
is schema:about of	named entity 'RESPIRATORY' named entity 'AREAS' named entity 'THAI' named entity 'CLOSE' named entity 'MAJORITY' named entity 'ANTIVIRAL' named entity 'FOLLOWED BY' named entity 'ABOUT' named entity 'NOVEMBER' named entity 'SENTINEL SURVEILLANCE' named entity 'RANGE' named entity 'VACCINATION COVERAGE' named entity 'REVERSE TRANSCRIPTASE' named entity 'ILLNESS' named entity 'AGE' named entity 'REMOTE' covid:arg/5f3f613be264f8b10318dfe8e92777fe7a95848e named entity 'VIRAL CULTURE' named entity 'RELATIONSHIPS' named entity 'CONSERVATION' named entity 'NEGATIVE' named entity 'RAINY SEASON' named entity 'CAMBODIAN' named entity 'AMINO' named entity 'THROAT' named entity '168' named entity 'WESTERN' named entity 'CAMBODIA' named entity 'ALMOST' named entity 'GENOMES' named entity 'SENTINEL' named entity 'PERFORMED' named entity 'ENTEROVIRUS' named entity 'JUNE' named entity 'ANALYSIS' named entity 'BORDER' named entity 'VIRAL PATHOGENS' named entity 'HUMAN' named entity 'FULL GENOME SEQUENCING' named entity 'MATCHING' named entity 'NASAL' named entity 'DECEMBER' named entity 'CASES' named entity 'INFLUENZA VACCINATION' named entity 'EV71' named entity '586' named entity 'ILI' named entity 'EARLIER' named entity 'BORDER' named entity 'SPECIMENS' named entity 'CIRCULATING' named entity 'CULTURED' named entity 'PHYLOGENETIC ANALYSIS' named entity 'SITES' named entity 'ISOLATED' named entity 'POPULATIONS' named entity 'COMBINED' named entity 'GENOME' named entity 'RELATED' named entity 'INFLUENZA' named entity 'OUTPATIENTS' named entity 'CAMBODIA' named entity 'LOW' named entity 'RHINOVIRUS' named entity 'SHARING' named entity 'RESPIRATORY VIRUSES' named entity 'STRAINS' named entity 'VACCINE' named entity 'PRESENTING' named entity 'LITTLE' named entity 'KNOWN' named entity 'WESTERN' named entity 'INFLUENZA' named entity 'REAL-TIME' named entity 'LIKE' named entity 'CIRCULATION'

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