About: Effects of interleukin 17A (IL-17A) neutralization on murine hepatitis virus (MHV-A59) infection

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About: Effects of interleukin 17A (IL-17A) neutralization on murine hepatitis virus (MHV-A59) infection Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

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type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Effects of interleukin 17A (IL-17A) neutralization on murine hepatitis virus (MHV-A59) infection
Creator	Coutelier, Jean-Paul Retegui, Lilia Aparicio, José Duhalde Vega, Maite Ottobre, Macarena Snick, Jacques
source	Medline; PMC
abstract	Mice infected with mouse hepatitis virus A59 (MHV-A59) develop hepatitis and autoantibodies (autoAb) to liver and kidney fumarylacetoacetate hydrolase (FAH), a fact closely related to the release of alarmins such as uric acid and/or high-mobility group box protein 1 (HMGB1). We studied the effect of neutralizing monoclonal antibodies (MAb) against IL-17A in our model of mouse MHV-A59-infection. MAb anti-IL-17F and anti-IFNγ were used to complement the study. Results showed that transaminase levels markedly decreased in MHV-A59-infected mice treated with MAb anti-IL-17A whereas plasmatic Ig concentration sharply increased. Conversely, MAb anti-IL-17F enhanced transaminase liberation and did not affect Ig levels. Serum IFNγ was detected in mice infected with MHV-A59 and its concentration increased after MAb anti-IL-17A administration. Besides, MAb anti-IFNγ greatly augmented transaminase plasmatic levels. IL-17A neutralization did not affect MHV-A59-induction of HMGB1 liberation and slightly augmented plasmatic uric acid concentration. However, mice treated with the MAb failed to produce autoAb to FAH. The above results suggest a reciprocal regulation of Th1 and Th17 cells acting on the different MHV-A59 effects. In addition, it is proposed that IL-17A is involved in alarmins adjuvant effects leading to autoAb expression.
has issue date	2017-12-12(xsd:dateTime)
bibo:doi	10.1684/ecn.2017.0399
bibo:pmid	29187338
has license	no-cc
sha1sum (hex)	5ce76c069e4031ee5bbe51500a608f6a8dba0b5d
schema:url	https://doi.org/10.1684/ecn.2017.0399
resource representing a document's title	Effects of interleukin 17A (IL-17A) neutralization on murine hepatitis virus (MHV-A59) infection
has PubMed Central identifier	PMC7099234
has PubMed identifier	29187338
schema:publication	Eur Cytokine Netw
resource representing a document's body	covid:5ce76c069e4031ee5bbe51500a608f6a8dba0b5d#body_text
is schema:about of	named entity 'A59' named entity '17A' named entity 'EXPRESSION' named entity 'MHV' named entity 'LIBERATION' named entity 'REGULATION' named entity 'TH17 CELLS' named entity 'TH1' named entity 'IL-17A' named entity 'GREATLY' named entity 'DID' named entity 'ALARMINS' named entity 'failed' named entity 'HMGB1' named entity 'transaminase' named entity 'MURINE HEPATITIS VIRUS' covid:arg/5ce76c069e4031ee5bbe51500a608f6a8dba0b5d named entity 'URIC ACID' named entity 'AFFECT' named entity 'INDUCTION' named entity 'HMGB1' named entity 'MICE' named entity 'CONCENTRATION' named entity '90%' named entity 'SUGGEST' named entity 'INTERLEUKIN 17A' named entity 'INFECTION' named entity 'EFFECTS' named entity 'INVOLVED' named entity 'EFFECTS' named entity 'RESULTS' named entity 'SLIGHTLY' named entity 'TRANSAMINASE' named entity 'MAB' named entity 'ADDITION' named entity 'ADJUVANT' named entity 'FAILED' named entity 'FAH' named entity 'A59' named entity 'AUGMENTED' named entity 'LEVELS' named entity 'RECIPROCAL' named entity 'TO PRODUCE' named entity 'TREATED WITH' named entity 'IFN' named entity 'PROPOSED' named entity 'DIFFERENT' named entity 'LEADING' named entity 'cells' named entity 'liberation' named entity 'addition' named entity 'levels' named entity 'However' named entity 'alarmins' named entity 'adjuvant' named entity 'Th1' named entity 'IL-17A' named entity 'IL-17A' named entity 'adjuvant' named entity 'mice' named entity 'C57BL/6' named entity 'IL-17A' named entity 'mice' named entity 'Statistical significance' named entity 'immune responses' named entity 'San Diego' named entity 'infection' named entity 'halothane' named entity 'Alanine aminotransferase' named entity 'Peroxidase' named entity 'Th1' named entity 'antigens' named entity 'transaminase' named entity 'Sigma-Aldrich' named entity 'IL-17A' named entity 'danger signals'

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