About: Immune effect of a Newcastle disease virus DNA vaccine with IL-12 as a molecular adjuvant delivered by electroporation

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About: Immune effect of a Newcastle disease virus DNA vaccine with IL-12 as a molecular adjuvant delivered by electroporation Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Immune effect of a Newcastle disease virus DNA vaccine with IL-12 as a molecular adjuvant delivered by electroporation
Creator	Ren, Tao Xie, Peng Ding, Chan Lin, Qiuyan Li, Yanling Xiang, Bin Liang, · Jin, Jiaqi Li, Yaling Xu, ·
source	PMC
abstract	Newcastle disease (ND), caused by virulent Newcastle disease virus (NDV) strains, has been one of the most problematic diseases affecting the poultry industry worldwide. Conventional vaccines provide effective protection for birds to survive ND outbreaks, but they may not completely suppress NDV shedding. NDV strains circulate on farms for a long time after the initial infection and cause potential risks. A new vaccine with fast clearance ability and low viral shedding is needed. In this study, we used interleukin-12 (IL-12) as an adjuvant and electroporation (EP) as an advanced delivery system to improve a DNA vaccine candidate. The fusion (F) protein gene from an NDV strain of the prevalent genotype VII.1.1 was cloned to prepare the vaccine. Chickens immunized with the F gene DNA vaccine co-delivered with an IL-12-expressing plasmid DNA showed higher neutralizing antibody levels and stronger concanavalin-A-induced lymphocyte proliferation than those treated with the F gene DNA vaccine alone. The co-delivered vaccine provided 100% protection, and less viral shedding and a shorter release time were observed in challenged chickens than when the F gene DNA vaccine was administered alone. The use of F gene DNA combined with IL-12 delivered by electroporation is a promising approach for vaccination against ND.
has issue date	2020-06-09(xsd:dateTime)
bibo:doi	10.1007/s00705-020-04669-5
has license	no-cc
sha1sum (hex)	5c6b4a4275855ce4c628783c42e563ef78c35dce
schema:url	https://doi.org/10.1007/s00705-020-04669-5
resource representing a document's title	Immune effect of a Newcastle disease virus DNA vaccine with IL-12 as a molecular adjuvant delivered by electroporation
has PubMed Central identifier	PMC7282469
schema:publication	Arch Virol
resource representing a document's body	covid:5c6b4a4275855ce4c628783c42e563ef78c35dce#body_text
is schema:about of	named entity 'DNA' named entity 'proliferation' named entity 'electroporation' named entity 'strain' named entity 'long' named entity 'levels' named entity 'Newcastle disease virus' named entity 'CONVENTIONAL' named entity 'BIRDS' named entity 'APPROACH' named entity 'AFFECTING' named entity 'CAUSED BY' named entity 'NEEDED' named entity 'CLEARANCE' named entity 'DELIVERED' named entity 'RISKS' named entity 'COMBINED' named entity 'FARMS' named entity 'NEUTRALIZING ANTIBODY' named entity 'A DNA' named entity 'FAST' named entity '1.1' named entity 'CLONED' named entity 'IS A' named entity 'DNA VACCINE CANDIDATE' named entity 'strains' named entity 'cloned' named entity 'virulent Newcastle disease' named entity 'outbreaks' named entity 'higher' named entity 'vaccine' named entity 'shedding' named entity 'IL-12' named entity 'combined' named entity 'gene' named entity 'adjuvant' named entity 'adjuvant' named entity 'DNA vaccine' named entity 'DNA vaccine' named entity 'vaccine' named entity '1.1' named entity 'vaccine' named entity 'gene' named entity 'Newcastle disease virus' named entity 'IL-12' named entity 'DNA vaccine' named entity '28 days' named entity 'lymphocyte' named entity 'ampicillin' named entity 'virus' named entity 'virus transmission' named entity 'Animal Health Products' named entity 'IL-12' named entity 'chicken' named entity 'PBS' named entity 'plasmid' named entity 'genotype' named entity 'IM injection' named entity 'immune response' named entity 'polyclonal antibody' named entity 'mitogen' named entity 'polyclonal antibody' named entity 'immune responses' named entity 'adjuvants' named entity 'viral envelope' named entity 'NDV' named entity 'NDV' named entity 'oropharyngeal' named entity 'DNA sequence' named entity 'goat' named entity 'NDV' named entity 'IM injection' named entity 'IL-12' named entity 'gene'

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