About: 2′-5′-Oligoadenylate synthetase 1 polymorphisms are associated with tuberculosis: a case-control study

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: 2′-5′-Oligoadenylate synthetase 1 polymorphisms are associated with tuberculosis: a case-control study Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	2′-5′-Oligoadenylate synthetase 1 polymorphisms are associated with tuberculosis: a case-control study
Creator	Wang, Yu Chen, Guo He, Jian-Qing Wang, Minggui Wu, Shouquan Zhang, Miaomiao
Source	Medline; PMC
abstract	BACKGROUND: 2′-5′-Oligoadenylate synthetase 1 (OAS1) plays an important role in inflammatory immune reactions. OAS1 polymorphisms have been associated with increased susceptibility to various diseases. We investigated the association of polymorphisms in OAS1 with tuberculosis (TB). METHODS: A total of 1215 TB cases and 1114 healthy controls were enrolled from two independent studies. Genotyping was conducted using the improved multiplex ligase detection reaction (iMLDR) method. Associations between OAS1 polymorphisms (rs2240190, rs1131454, 10,774,671 and 11,066,453) and TB risk were established based on distributions of allelic frequencies using different genetic models. RESULTS: Significant association was observed between rs10774671, rs1131454 and TB. In the initial study, the G allele of rs10774671 was a significantly protective factor against TB (P = 0.006) and the genotype of GG differed significantly between TB patients and controls under the codominant model (P = 0.008) after Bonferroni correction. In the validation study, we also observed that the rs10774671 G allele (P = 0.001) and GG genotype (P = 0.001) were associated with TB. In addition, we found that the rs1131454 G allele (P = 0.004) and GG genotype (P = 0.001) were protective against TB in the Chinese Han population. CONCLUSIONS: We report novel associations of polymorphisms in OAS1 with TB in the Chinese Tibetan and Han populations. Similar studies in different populations and functional studies are warranted to confirm our results.
has issue date	2018-11-29(xsd:dateTime)
bibo:doi	10.1186/s12890-018-0746-x
bibo:pmid	30497421
has license	cc-by
sha1sum (hex)	5c5491d07d2c4e996988e591b870ed272d2f944e
schema:url	https://doi.org/10.1186/s12890-018-0746-x
resource representing a document's title	2′-5′-Oligoadenylate synthetase 1 polymorphisms are associated with tuberculosis: a case-control study
has PubMed Central identifier	PMC6267069
has PubMed identifier	30497421
schema:publication	BMC Pulm Med
resource representing a document's body	covid:5c5491d07d2c4e996988e591b870ed272d2f944e#body_text
is schema:about of	named entity 'SYNTHETASE' named entity 'conducted' named entity 'reactions' named entity 'improved' named entity 'INVESTIGATED' named entity 'LIGASE DETECTION REACTION' named entity 'VARIOUS' named entity 'GENETIC MODELS' named entity 'GENOTYPING' named entity 'HEALTHY' named entity 'REACTIONS' named entity 'PLAYS' named entity 'STUDIES' named entity 'RISK' named entity 'DISEASES' named entity 'HAVE' named entity 'OLIGOADENYLATE' named entity '80%' named entity '10%' named entity 'ASSOCIATION' named entity 'METHODS' named entity 'IMPORTANT' named entity 'DIFFERENT' named entity 'METHOD' named entity 'ASSOCIATED WITH' named entity 'TOTAL' named entity 'ASSOCIATIONS' named entity 'FREQUENCIES' named entity 'ESTABLISHED' named entity 'USING' named entity 'SYNTHETASE' named entity 'IMPROVED' named entity 'INFLAMMATORY' named entity 'BACKGROUND' named entity 'OLIGOADENYLATE' named entity '80%' named entity 'TUBERCULOSIS' named entity 'CASE-CONTROL STUDY' named entity 'ASSOCIATED WITH' named entity 'OAS1' named entity 'INDEPENDENT' named entity 'BASED' named entity '1114' named entity 'DISTRIBUTIONS' named entity 'TUBERCULOSIS' named entity 'ROLE' named entity 'IMMUNE' named entity 'POLYMORPHISMS' named entity 'ENROLLED' named entity 'MULTIPLEX' named entity 'POLYMORPHISMS' named entity 'INCREASED SUSCEPTIBILITY' named entity 'CASES' covid:arg/5c5491d07d2c4e996988e591b870ed272d2f944e named entity 'independent studies' named entity 'dengue' named entity 'OAS1' named entity 'OAS' named entity 'OAS' named entity 'latent TB' named entity 'tuberculosis' named entity 'total' named entity 'OAS1' named entity 'OAS1' named entity 'allelic frequencies' named entity 'tuberculosis' named entity 'histological' named entity 'respiratory infection' named entity 'enzyme' named entity 'gene' named entity 'eQTL' named entity 'infection' named entity 'minor allele frequency' named entity 'multiple comparisons' named entity 'apoptosis' named entity 'genotype'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2025 OpenLink Software