About: Evolution and Variation of the SARS-CoV Genome

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About: Evolution and Variation of the SARS-CoV Genome Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Evolution and Variation of the SARS-CoV Genome
Creator	Wei, Wei Wang, Jian Li, Wei Wang, Jing Li, Yan Wang, Jun Hu, Jianfei Yu, Jun Han, Yujun Ji, Jia Li, Songgang Xu, Jing Yang, Huanming Zhang, Zizhang Xu, Zhao Ye, Jia
Source	Elsevier; Medline; PMC
abstract	Knowledge of the evolution of pathogens is of great medical and biological significance to the prevention, diagnosis, and therapy of infectious diseases. In order to understand the origin and evolution of the SARS-CoV (severe acute respiratory syndrome-associated coronavirus), we collected complete genome sequences of all viruses available in GenBank, and made comparative analyses with the SARS-CoV. Genomic signature analysis demonstrates that the coronaviruses all take the TGTT as their richest tetranucleotide except the SARS-CoV. A detailed analysis of the forty-two complete SARS-CoV genome sequences revealed the existence of two distinct genotypes, and showed that these isolates could be classified into four groups. Our manual analysis of the BLASTN results demonstrates that the HE (hemagglutinin-esterase) gene exists in the SARS-CoV, and many mutations made it unfamiliar to us.
has issue date	2016-11-28(xsd:dateTime)
bibo:doi	10.1016/s1672-0229(03)01027-1
bibo:pmid	15629034
has license	cc-by-nc-nd
sha1sum (hex)	5bc13185f8fc98b99cd1fb22078afeda41eb1e7e
schema:url	https://doi.org/10.1016/s1672-0229%2803%2901027-1
resource representing a document's title	Evolution and Variation of the SARS-CoV Genome
has PubMed Central identifier	PMC5172238
has PubMed identifier	15629034
schema:publication	Genomics Proteomics Bioinformatics
resource representing a document's body	covid:5bc13185f8fc98b99cd1fb22078afeda41eb1e7e#body_text
is schema:about of	named entity 'GENOME' named entity 'collected' named entity 'coronavirus' named entity 'therapy' named entity 'detailed' named entity 'evolution' named entity 'Our' named entity 'origin' named entity 'classified' named entity 'SARS-CoV' named entity 'DISTINCT' named entity 'CORONAVIRUSES' named entity 'COMPLETE' named entity 'ANALYSIS' named entity 'GROUPS' named entity 'ASSOCIATED' named entity 'EXCEPT' named entity 'THEIR' named entity 'DETAILED' named entity 'UNFAMILIAR' named entity 'REVEALED' named entity 'PREVENTION' named entity 'SIGNATURE' named entity 'GREAT' named entity 'ORIGIN' named entity 'MANUAL' named entity 'ISOLATES' named entity 'SARS-COV' named entity 'GENBANK' named entity 'SYNDROME' named entity 'EVOLUTION' named entity 'RESPIRATORY' named entity 'CLASSIFIED' named entity 'COULD BE' named entity 'SARS-COV' named entity 'ORDER' named entity 'THERAPY' named entity 'EVOLUTION' named entity 'GENOME' named entity 'GENOMIC' named entity 'SIGNIFICANCE' named entity 'UNDERSTAND' named entity 'GENOTYPES' named entity 'GENE' named entity 'ACUTE' named entity 'PATHOGENS' named entity 'MUTATIONS' named entity 'FORTY' named entity 'BIOLOGICAL' named entity 'OUR' named entity 'VARIATION' named entity 'VIRUSES' named entity 'AVAILABLE' named entity 'KNOWLEDGE' named entity 'ESTERASE' named entity 'INFECTIOUS DISEASES' named entity 'RESULTS' named entity 'CORONAVIRUS' named entity 'THESE' named entity 'DIAGNOSIS' named entity 'MEDICAL' named entity 'SEQUENCES' named entity 'COLLECTED' named entity 'BLASTN' covid:arg/5bc13185f8fc98b99cd1fb22078afeda41eb1e7e named entity 'revealed'

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