About: Crystallographic analysis of the N-terminal domain of Middle East respiratory syndrome coronavirus nucleocapsid protein

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About: Crystallographic analysis of the N-terminal domain of Middle East respiratory syndrome coronavirus nucleocapsid protein Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
title	Crystallographic analysis of the N-terminal domain of Middle East respiratory syndrome coronavirus nucleocapsid protein
Creator	Hou, Ming-Hon Wang, Yong-Sheng Chang, Chung-Ke
source	Medline; PMC
abstract	The N-terminal domain of the nucleocapsid protein from Middle East respiratory syndrome coronavirus (MERS-CoV NP-NTD) contains many positively charged residues and has been identified to be responsible for RNA binding during ribonucleocapsid formation by the virus. In this study, the crystallization and crystallographic analysis of MERS-CoV NP-NTD (amino acids 39–165), with a molecular weight of 14.7 kDa, are reported. MERS-CoV NP-NTD was crystallized at 293 K using PEG 3350 as a precipitant and a 94.5% complete native data set was collected from a cooled crystal at 77 K to 2.63 Å resolution with an overall R (merge) of 9.6%. The crystals were monoclinic and belonged to space group P2(1), with unit-cell parameters a = 35.60, b = 109.64, c = 91.99 Å, β = 101.22°. The asymmetric unit contained four MERS-CoV NP-NTD molecules.
has issue date	2015-07-28(xsd:dateTime)
bibo:doi	10.1107/s2053230x15010146
bibo:pmid	26249685
has license	bronze-oa
sha1sum (hex)	5af9e4a65be59fd7da207e0f8c77accbc9d7c2ff
schema:url	https://doi.org/10.1107/s2053230x15010146
resource representing a document's title	Crystallographic analysis of the N-terminal domain of Middle East respiratory syndrome coronavirus nucleocapsid protein
has PubMed Central identifier	PMC4528927
has PubMed identifier	26249685
schema:publication	Acta Crystallographica Section F Structural Biology Communications
resource representing a document's body	covid:5af9e4a65be59fd7da207e0f8c77accbc9d7c2ff#body_text
is schema:about of	named entity 'MERS-CoV' named entity 'precipitant' named entity 'amino acids' named entity 'ribonucleocapsid' named entity 'molecular weight' named entity 'unit-cell parameters' named entity 'virus' named entity 'nucleocapsid protein' named entity 'Crystallographic analysis' named entity 'N-terminal' named entity 'esterase' named entity 'PMSF' named entity 'MERS-CoV' named entity 'MHV' named entity 'RNP' named entity 'HCoV-NL63' named entity 'nucleocapsid' named entity 'RNA' named entity 'MERS-CoV' named entity 'MERS-CoV' named entity 'centrifugation' named entity 'IBV' named entity 'worldwide epidemic' named entity 'IPTG' named entity 'HCoV-OC43' named entity 'Human coronavirus OC43' named entity 'Netherlands' named entity 'capsid' named entity 'nucleic acids' named entity 'Taiwan' named entity 'protein' named entity '8.5' named entity 'unit-cell parameters' named entity 'Crystallographic' named entity 'protein' named entity 'bacteria' named entity 'Macromolecule' named entity 'crystallization' named entity 'C-terminal' named entity 'structural proteins' named entity 'PCR' named entity 'haemagglutinin' named entity 'primers' named entity 'N-terminal domain' named entity 'alphacoronavirus' named entity 'Japan' named entity 'homology search' named entity 'centrifugation' named entity 'gene' named entity '250 mM' named entity 'MERS-CoV' named entity 'diffusion' named entity 'Novagen' named entity 'cloned' named entity 'Tris-HCl' named entity 'International Union of Crystallography' named entity 'SARS-CoV' named entity 'incubation' named entity 'plasmid' named entity 'sonication' named entity 'Novagen' named entity 'protein' named entity 'protein' named entity 'centrifugation' named entity 'space group' named entity 'supernatant' named entity 'X-ray diffraction' named entity 'Jayaram' named entity 'protein' named entity 'MERS-CoV' named entity 'lysed' named entity 'SARS-CoV' named entity 'protein' named entity 'bronchiolitis' named entity 'RIKEN' named entity 'NaCl' named entity 'centrifugation' named entity 'polymerase chain reaction' named entity 'crystallographic'

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