About: Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies
Creator	Xiong, Yong Xiao, Shu-Yuan Liu, Huan Tian, Sufang Li, • Liao, Meiyan Guo, Jianchun
Source	Medline; PMC
abstract	Data on pathologic changes of the 2019 novel coronavirus disease (COVID-19) are scarce. To gain knowledge about the pathology that may contribute to disease progression and fatality, we performed postmortem needle core biopsies of lung, liver, and heart in four patients who died of COVID-19 pneumonia. The patients’ ages ranged from 59 to 81, including three males and one female. Each patient had at least one underlying disease, including immunocompromised status (chronic lymphocytic leukemia and renal transplantation) or other conditions (cirrhosis, hypertension, and diabetes). Time from disease onset to death ranged from 15 to 52 days. All patients had elevated white blood cell counts, with significant rise toward the end, and all had lymphocytopenia except for the patient with leukemia. Histologically, the main findings are in the lungs, including injury to the alveolar epithelial cells, hyaline membrane formation, and hyperplasia of type II pneumocytes, all components of diffuse alveolar damage. Consolidation by fibroblastic proliferation with extracellular matrix and fibrin forming clusters in airspaces is evident. In one patient, the consolidation consists of abundant intra-alveolar neutrophilic infiltration, consistent with superimposed bacterial bronchopneumonia. The liver exhibits mild lobular infiltration by small lymphocytes, and centrilobular sinusoidal dilation. Patchy necrosis is also seen. The heart shows only focal mild fibrosis and mild myocardial hypertrophy, changes likely related to the underlying conditions. In conclusion, the postmortem examinations show advanced diffuse alveolar damage, as well as superimposed bacterial pneumonia in some patients. Changes in the liver and heart are likely secondary or related to the underlying diseases.
has issue date	2020-04-14(xsd:dateTime)
bibo:doi	10.1038/s41379-020-0536-x
bibo:pmid	32291399
has license	no-cc
sha1sum (hex)	5ae64627f2de0b67903a630d28881e9dd0d9dde4
schema:url	https://doi.org/10.1038/s41379-020-0536-x
resource representing a document's title	Pathological study of the 2019 novel coronavirus disease (COVID-19) through postmortem core biopsies
has PubMed Central identifier	PMC7156231
has PubMed identifier	32291399
schema:publication	Mod Pathol
resource representing a document's body	covid:5ae64627f2de0b67903a630d28881e9dd0d9dde4#body_text
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