About: scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells

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About: scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells
Creator	Xu, Xiaojiang Wang, Zhengpin
Source	Medline; PMC
abstract	In December 2019, a novel coronavirus (SARS-CoV-2) was identified in COVID-19 patients in Wuhan, Hubei Province, China. SARS-CoV-2 shares both high sequence similarity and the use of the same cell entry receptor, angiotensin-converting enzyme 2 (ACE2), with severe acute respiratory syndrome coronavirus (SARS-CoV). Several studies have provided bioinformatic evidence of potential routes of SARS-CoV-2 infection in respiratory, cardiovascular, digestive and urinary systems. However, whether the reproductive system is a potential target of SARS-CoV-2 infection has not yet been determined. Here, we investigate the expression pattern of ACE2 in adult human testes at the level of single-cell transcriptomes. The results indicate that ACE2 is predominantly enriched in spermatogonia and Leydig and Sertoli cells. Gene Set Enrichment Analysis (GSEA) indicates that Gene Ontology (GO) categories associated with viral reproduction and transmission are highly enriched in ACE2-positive spermatogonia, while male gamete generation related terms are downregulated. Cell–cell junction and immunity-related GO terms are increased in ACE2-positive Leydig and Sertoli cells, but mitochondria and reproduction-related GO terms are decreased. These findings provide evidence that the human testis is a potential target of SARS-CoV-2 infection, which may have significant impact on our understanding of the pathophysiology of this rapidly spreading disease.
has issue date	2020-04-09(xsd:dateTime)
bibo:doi	10.3390/cells9040920
bibo:pmid	32283711
has license	cc-by
sha1sum (hex)	5ad6109d1a52f59f630969bb8792652be6a515e7
schema:url	https://doi.org/10.3390/cells9040920
resource representing a document's title	scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells
has PubMed Central identifier	PMC7226809
has PubMed identifier	32283711
schema:publication	Cells
resource representing a document's body	covid:5ad6109d1a52f59f630969bb8792652be6a515e7#body_text
is schema:about of	named entity 'human' named entity 'The' named entity 'reproduction' named entity 'systems' named entity 'cardiovascular' named entity 'digestive' named entity 'impact' named entity 'ACE2 Receptor' named entity 'INCREASED' named entity 'HIGH' named entity 'TRANSMISSION' named entity 'EXPRESSION PATTERN' named entity 'RAPIDLY' named entity 'ENRICHED' named entity 'routes' named entity 'positive' named entity 'Leydig' named entity 'Hubei Province' named entity 'SARS-CoV-2' named entity 'potential' named entity 'ACE2' named entity 'gamete' named entity 'reproductive system' named entity 'human' named entity 'Sertoli cells' named entity 'infection' named entity 'adult' named entity 'transcriptomes' named entity 'viral' named entity 'Gene Ontology' named entity 'spermatogonia' named entity 'Sertoli' named entity 'Leydig' named entity 'testes' named entity 'SARS-CoV' named entity 'spreading disease' named entity 'ACE2' named entity 'SARS-CoV-2' named entity 'mitochondria' named entity 'significant impact' named entity 'cardiovascular' named entity 'Sertoli' named entity 'Gene Ontology' named entity 'severe acute respiratory syndrome coronavirus' named entity 'scRNA-seq' named entity 'Testes' named entity 'SARS-CoV-2' named entity 'Spermatogonia' named entity 'determined' named entity 'target' named entity 'PPIA' named entity 'spermatogenesis' named entity 'ACE2' named entity 'ACE2' named entity 'COVID' named entity 'gene' named entity 'germ cell' named entity 'spermatogonia' named entity 'angiotensin-converting enzyme 2' named entity 'germ cell' named entity 'Wuhan' named entity 'quality control' named entity 'protein-coding' named entity 'CDH2' named entity 'spermatogenic cells' named entity 'ACE2' named entity 'respiratory symptoms' named entity 'SLIRP' named entity 'ACE2' named entity 'colon' named entity 'viral budding' named entity 'SARS-CoV-2' named entity 'mitochondrial' named entity 'Sertoli' named entity 'SORD' named entity 'RHOA' named entity 'spermatid' named entity 'marker gene' named entity 'gene' named entity 'TOP2A'

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