About: Attenuation of a virulent swine acute diarrhea syndrome coronavirus strain via cell culture passage

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About: Attenuation of a virulent swine acute diarrhea syndrome coronavirus strain via cell culture passage Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Attenuation of a virulent swine acute diarrhea syndrome coronavirus strain via cell culture passage
Creator	Ma, J Zhou, Z Zhou, L Li, Q Luo, Y Wu, Z Yan, X Sun, Y Cheng, J He, L Lan, T Tan, Y Wu, R
Source	Elsevier; Medline; PMC
abstract	Abstract Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a newly identified enteric alphacoronavirus that causes fatal diarrhea in newborn piglets in China. Here, we propagated a virulent strain SADS-CoV/CN/GDWT/2017 in Vero cells for up to 83 passages. Four strains of SADS-CoV/GDWT-P7, -P18, -P48 and -P83 were isolated and characterized. Sequence alignments showed that these four novel strains exhibited 16 nucleotide mutations and resultant 10 amino acid substitutions in open reading frame 1a/1b, spike, NS3a, envelope, membrane and nucleocapsid proteins. Furthermore, a 58-bp deletion in NS7a/7b was found in P48 and P83 strains, which led to the loss of NS7b and 38 amino acid changes of NS7a. Pig infection studies showed that the P7 strain caused typical watery diarrhea, while the P83 strain induced none-to-mild, delayed and transient diarrhea. This is the first report on cell adaption of a virulent SADS-CoV strain, which gives information on the potential virulence determinants of SADS-CoV.
has issue date	2019-12-31(xsd:dateTime)
bibo:doi	10.1016/j.virol.2019.09.009
bibo:pmid	31580972
has license	els-covid
sha1sum (hex)	596d96c266397f1c9b78803426ba5ec362df5626
schema:url	https://doi.org/10.1016/j.virol.2019.09.009
resource representing a document's title	Attenuation of a virulent swine acute diarrhea syndrome coronavirus strain via cell culture passage
has PubMed Central identifier	PMC7112038
has PubMed identifier	31580972
schema:publication	Virology
resource representing a document's body	covid:596d96c266397f1c9b78803426ba5ec362df5626#body_text
is schema:about of	named entity 'VIRULENT' named entity 'identified' named entity 'diarrhea' named entity 'P83' named entity 'strains' named entity 'ATTENUATION' named entity 'SWINE ACUTE DIARRHEA SYNDROME CORONAVIRUS' named entity 'TRANSIENT' named entity 'CHARACTERIZED' named entity 'VIRULENT' named entity 'FOUND' named entity 'ENTERIC' named entity 'TYPICAL' named entity 'DELETION' named entity 'UP TO' named entity 'AMINO ACID' named entity 'P18' named entity 'INFECTION' named entity 'ISOLATED' named entity 'VIRULENT STRAIN' named entity 'FATAL' named entity 'NUCLEOTIDE' named entity 'ALPHACORONAVIRUS' named entity 'AMINO ACID SUBSTITUTIONS' named entity 'LED' named entity 'IDENTIFIED' named entity 'ADAPTION' named entity 'STRAIN' named entity 'MILD' named entity 'OPEN READING FRAME' named entity 'SPIKE' named entity 'NOVEL' named entity 'DIARRHEA' named entity 'VIRULENCE' named entity 'ENVELOPE' named entity 'HERE' named entity 'VERO CELLS' named entity 'INFORMATION' named entity 'CHINA' named entity 'IS A' named entity 'CELL CULTURE' named entity 'DETERMINANTS' named entity 'PIG' named entity 'SEQUENCE' named entity 'MEMBRANE' named entity 'INDUCED' named entity 'DELAYED' named entity 'CAUSES' named entity 'NEWLY' named entity 'STRAINS' named entity 'STUDIES' named entity 'REPORT' named entity 'THESE' named entity 'STRAIN' named entity 'PASSAGE' named entity 'WATERY DIARRHEA' named entity 'NEWBORN' named entity 'LOSS OF' named entity 'MUTATIONS' named entity 'P83' named entity 'CHANGES' named entity 'ON CELL' named entity 'POTENTIAL' named entity 'NUCLEOCAPSID PROTEINS' named entity 'SWINE ACUTE DIARRHEA SYNDROME CORONAVIRUS' named entity 'P48' covid:arg/596d96c266397f1c9b78803426ba5ec362df5626 named entity 'strains' named entity 'membrane'

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