About: Simultaneous outbreaks of respiratory disease in wild chimpanzees caused by distinct viruses of human origin

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Simultaneous outbreaks of respiratory disease in wild chimpanzees caused by distinct viruses of human origin Goto Sponge NotDistinct Permalink

An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Simultaneous outbreaks of respiratory disease in wild chimpanzees caused by distinct viruses of human origin
Creator	Pappas, Tressa Hyeroba, David Machanda, Zarin Otali, Emily Phillips-Garcia, Sarah Gern, James Grindle, Kristine Goldberg, Tony Palmenberg, Ann Langergraber, Kevin Mitani, John Muller, Martin Negrey, Jacob Owens, Leah Reddy, Rachna Scully, Erik Wrangham, Richard Thompson, Melissa
Source	Medline; PMC
abstract	Respiratory viruses of human origin infect wild apes across Africa, sometimes lethally. Here we report simultaneous outbreaks of two distinct human respiratory viruses, human metapneumovirus (MPV; Pneumoviridae: Metapneumovirus) and human respirovirus 3 (HRV3; Paramyxoviridae; Respirovirus, formerly known as parainfluenza virus 3), in two chimpanzee (Pan troglodytes schweinfurthii) communities in the same forest in Uganda in December 2016 and January 2017. The viruses were absent before the outbreaks, but each was present in ill chimpanzees from one community during the outbreak period. Clinical signs and gross pathologic changes in affected chimpanzees closely mirrored symptoms and pathology commonly observed in humans for each virus. Epidemiologic modelling showed that MPV and HRV3 were similarly transmissible (R(0) of 1.27 and 1.48, respectively), but MPV caused 12.2% mortality mainly in infants and older chimpanzees, whereas HRV3 caused no direct mortality. These results are consistent with the higher virulence of MPV than HRV3 in humans, although both MPV and HRV3 cause a significant global disease burden. Both viruses clustered phylogenetically within groups of known human variants, with MPV closely related to a lethal 2009 variant from mountain gorillas (Gorilla beringei beringei), suggesting two independent and simultaneous reverse zoonotic origins, either directly from humans or via intermediary hosts. These findings expand our knowledge of human origin viruses threatening wild chimpanzees and suggest that such viruses might be differentiated by their comparative epidemiological dynamics and pathogenicity in wild apes. Our results also caution against assuming common causation in coincident outbreaks.
has issue date	2019-01-21(xsd:dateTime)
bibo:doi	10.1080/22221751.2018.1563456
bibo:pmid	30866768
has license	cc-by
sha1sum (hex)	57a145d6bea3653336fdd964a6d1e0494c32fcf4
schema:url	https://doi.org/10.1080/22221751.2018.1563456
resource representing a document's title	Simultaneous outbreaks of respiratory disease in wild chimpanzees caused by distinct viruses of human origin
has PubMed Central identifier	PMC6455141
has PubMed identifier	30866768
schema:publication	Emerg Microbes Infect
resource representing a document's body	covid:57a145d6bea3653336fdd964a6d1e0494c32fcf4#body_text
is schema:about of	named entity 'CHIMPANZEES' named entity 'RESPIRATORY DISEASE' named entity 'VIRUSES' named entity 'AFFECTED' named entity 'DIFFERENTIATED' named entity 'CONSISTENT WITH' named entity 'KNOWLEDGE' named entity 'BUT' named entity 'CHIMPANZEE' named entity 'HUMANS' named entity 'CAUTION' named entity 'UGANDA' named entity 'PNEUMOVIRIDAE' named entity 'HUMAN METAPNEUMOVIRUS' named entity 'GORILLAS' named entity 'HERE' named entity 'ABSENT' named entity 'BURDEN' named entity 'AFRICA' named entity 'PATHOLOGIC' named entity 'INDEPENDENT' named entity 'DISTINCT' named entity 'METAPNEUMOVIRUS' named entity 'FINDINGS' named entity 'DECEMBER' named entity 'COMMUNITIES' named entity 'SYMPTOMS' named entity 'MPV' named entity 'FOREST' named entity 'REPORT' named entity 'KNOWN' named entity 'WILD' named entity 'HOSTS' named entity 'VIRUSES' named entity 'INFECT' named entity 'SIMULTANEOUS' named entity 'MODELLING' named entity 'CHIMPANZEES' named entity 'RELATED' named entity 'VIRULENCE' named entity 'GROUPS' named entity 'OBSERVED' named entity 'EITHER' named entity 'VARIANTS' named entity 'OUTBREAKS' named entity 'PATHOGENICITY' named entity 'THESE' named entity 'EPIDEMIOLOGIC' named entity 'LETHAL' named entity 'EXPAND' named entity 'HUMAN' covid:arg/57a145d6bea3653336fdd964a6d1e0494c32fcf4 named entity 'INTERMEDIARY' named entity 'ZOONOTIC' named entity 'DYNAMICS' named entity 'PRESENT' named entity 'HUMAN ORIGIN' named entity 'CAUSED BY' named entity 'DISTINCT' named entity 'SIMULTANEOUS' named entity 'WILD' named entity 'HUMAN ORIGIN' named entity 'JANUARY' named entity 'PARAINFLUENZA VIRUS 3'

Faceted Search & Find service v1.13.91 as of Mar 24 2020

Alternative Linked Data Documents: Sponger | ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3229 as of Jul 10 2020, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (94 GB total memory)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software