About: Gliopathy of Demyelinating and Non-Demyelinating Strains of Mouse Hepatitis Virus

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An Entity of Type : schema:ScholarlyArticle, within Data Space : covidontheweb.inria.fr associated with source document(s)

Attributes	Values
type	Academic Article research paper schema:ScholarlyArticle
isDefinedBy	Covid-on-the-Web dataset
has title	Gliopathy of Demyelinating and Non-Demyelinating Strains of Mouse Hepatitis Virus
Creator	Das Sarma, Jayasri Biswas, Kaushiki Nabar, Manasi Stout, Marjorie Grinspan, Judith Hingley, Susan Kenyon, Lawrence Shindler, Kenneth Fernandes, Adelaide Pizzorusso, Tommaso Weissert, Robert
Source	PMC
abstract	Demyelination in the central nervous system induced by neurovirulent strains of Mouse Hepatitis Virus (MHV) is mediated by the viral spike glycoprotein, but it is not clear whether the mechanism of this disease pathology involves direct viral infection of oligodendrocytes. Detailed studies of glial cell tropism of MHV are presented, demonstrating that direct MHV infection of oligodendrocytes differs between demyelinating (RSA59) and non-demyelinating (RSMHV2) viral strains both in vitro and in vivo. Our results indicate that direct injury of mature oligodendrocytes is an important mechanism of virus-induced demyelination. In vivo, RSA59 infection was identified in spinal cord gray and white matter, but infected oligodendrocytes were restricted to white matter. In contrast, RSMHV2 infection was restricted to gray matter neurons and was not localized to oligodendrocytes. In vitro, RSA59 can infect both oligodendrocyte precursors and differentiated oligodendrocytes, whereas RSMHV2 can infect oligodendrocyte precursors but not differentiated oligodendrocytes. Viral spreading through axonal means to white matter and release of the demyelinating strain MHV at the nerve end is critical for oligodendrocytes infection and subsequent demyelination. Understanding the mechanisms by which known viruses effect demyelination in this animal model has important therapeutic implications in the treatment of human demyelinating disease.
has issue date	2015-12-22(xsd:dateTime)
bibo:doi	10.3389/fncel.2015.00488
bibo:pmid	26733813
has license	cc-by
sha1sum (hex)	575faff450d20d0f359d000ebc8b66b638094613
schema:url	https://doi.org/10.3389/fncel.2015.00488
resource representing a document's title	Gliopathy of Demyelinating and Non-Demyelinating Strains of Mouse Hepatitis Virus
has PubMed Central identifier	PMC4686739
has PubMed identifier	26733813
schema:publication	Front Cell Neurosci
resource representing a document's body	covid:575faff450d20d0f359d000ebc8b66b638094613#body_text
is schema:about of	named entity 'gray' named entity 'therapeutic' named entity 'infection' named entity 'Strains' named entity 'KNOWN' covid:arg/575faff450d20d0f359d000ebc8b66b638094613 named entity 'CLEAR' named entity 'STUDIES' named entity 'STRAINS' named entity 'CRITICAL' named entity 'IN VIVO' named entity 'MEDIATED' named entity 'INFECT' named entity 'MOUSE HEPATITIS VIRUS' named entity 'GRAY' named entity 'DETAILED' named entity 'VIRUS' named entity 'STRAINS' named entity 'NON-' named entity 'RESULTS' named entity 'LOCALIZED' named entity 'SPREADING' named entity 'DIRECT' named entity 'DEMYELINATING DISEASE' named entity 'INFECTION' named entity 'VIRAL INFECTION' named entity 'MECHANISMS' named entity 'MOUSE HEPATITIS VIRUS' named entity 'UNDERSTANDING' named entity 'THERAPEUTIC' named entity 'INJURY' named entity 'BUT' named entity 'OUR' named entity 'MEANS' named entity 'STRAIN' named entity 'PRESENTED' named entity 'EFFECT' named entity 'SPINAL CORD' named entity 'RESTRICTED' named entity 'SUBSEQUENT' named entity 'CENTRAL NERVOUS SYSTEM' named entity 'DEMYELINATION' named entity 'GRAY MATTER' named entity 'IN VITRO' named entity 'DIFFERENTIATED' named entity 'VIRAL' named entity 'INDUCED' named entity 'IMPORTANT' named entity 'VIRUSES' named entity 'TROPISM' named entity 'IDENTIFIED' named entity 'INFECTED' named entity 'MECHANISM' named entity 'PRECURSORS' named entity 'RELEASE' named entity 'TREATMENT' named entity 'NON-' named entity 'OLIGODENDROCYTE' named entity 'WHITE MATTER' named entity 'HUMAN' named entity 'ANIMAL MODEL' named entity 'OLIGODENDROCYTES' named entity 'GLIAL CELL' named entity 'DISEASE' named entity 'NERVE END' named entity 'AXONAL' named entity 'MATURE' named entity 'CONTRAST' named entity 'NEURONS' named entity 'PATHOLOGY' named entity 'contrast'

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